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Andreas von Sprecher
Researcher at Novartis
Publications - 29
Citations - 294
Andreas von Sprecher is an academic researcher from Novartis. The author has contributed to research in topics: Alkyl & Trifluoromethyl. The author has an hindex of 10, co-authored 29 publications receiving 291 citations. Previous affiliations of Andreas von Sprecher include Actelion.
Papers
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Journal ArticleDOI
The synthesis of pyridine derivatives from 3‐formylchromone
TL;DR: In this article, the pyridine ring forming reactions are discussed and the factors determining the formation and regiospecificity of the ring-forming reactions are also discussed, as well as the properties of pyridines.
Journal ArticleDOI
Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy
Cyrille Lescop,Holger Herzner,Hervé Siendt,Reto Bolliger,Marco Henneböhle,Philipp Weyermann,Alexandre Briguet,Isabelle Courdier-Fruh,Michael Erb,Mark Foster,Thomas Meier,Josef P. Magyar,Andreas von Sprecher +12 more
TL;DR: Several novel calpain inhibitors have shown positive effects on histological parameters in an animal model of Duchenne muscular dystrophy demonstrating their potential as a treatment option for this fatal disease.
Patent
Alpha-keto carbonyl calpain inhibitors
Philipp Weyermann,Andreas von Sprecher,Marco Henneböhle,Holger Herzner,Cyrille Lescop,Hervé Siendt +5 more
TL;DR: In this article, the α-keto carbonyl calpain inhibitors for the treatment of neurodegenerative diseases and neuromuscular diseases including Duchenne Muscular dystrophy, Becker Muscular Dystrophy and other muscular dystrophies were presented.
Journal ArticleDOI
Dual neurokinin NK1/NK2 antagonists: N-[(R,R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamides and 3-[N′-3,5-bis(trifluoromethyl)benzoyl-N-arylmethyl-N′-methylhydrazino]-N-[(R)-2-oxo-azepan-3-yl]propionamides
Marc Gerspacher,Luigi La Vecchia,Robert Mah,Andreas von Sprecher,Gary P. Anderson,Natarajan Subramanian,Kathleen Hauser,Heinrich Bammerlin,S. Kimmel,Viviane Pawelzik,Karin Ryffel,Howard A. Ball +11 more
TL;DR: Simplification of the structure via elimination of a chiral centre led to 3-[N'-3,5-bis(trifluoromethyl)benzoyl-N-(3,4-dichlorobenzyl)-N'-methylhydrazino]-N-[(R)-2-oxo-azepan-3-yl]propionamide (22), a potent and fairly balanced NK(1)/NK(2) antagonist.
Journal ArticleDOI
Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class
Andreas von Sprecher,Marc Gerspacher,Andreas Beck,S. Kimmel,Hansruedi Wiestner,Gary P. Anderson,U. Niederhauser,Natarajan Subramanian,M. A. Bray +8 more
TL;DR: The two geminal ethyl groups in the succinic acid moiety of CGP57698 are responsible for the high in vitro and in vivo potency of this peptidoleukotriene antagonist of the quinoline type.