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Andres A. Paucar
Researcher at University of California, Los Angeles
Publications - 9
Citations - 1591
Andres A. Paucar is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Neural stem cell & Stem cell. The author has an hindex of 8, co-authored 9 publications receiving 1400 citations. Previous affiliations of Andres A. Paucar include Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner
Janel E. Le Belle,Nicolas M. Orozco,Andres A. Paucar,Jonathan P. Saxe,Jack Mottahedeh,April D. Pyle,Hong Wu,Harley I. Kornblum +7 more
TL;DR: This study has identified a redox-mediated regulatory mechanism of NSC function that may have significant implications for brain injury, disease, and repair.
Journal ArticleDOI
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.
David Nathanson,Beatrice Gini,Jack Mottahedeh,Koppany Visnyei,Tomoyuki Koga,German G. Gomez,Ascia Eskin,Kiwook Hwang,Jun Wang,Kenta Masui,Andres A. Paucar,Huijun Yang,Minori Ohashi,Shaojun Zhu,Jill Wykosky,Rachel Reed,Stanley F. Nelson,Timothy F. Cloughesy,C. David James,P. Nagesh Rao,Harley I. Kornblum,James R. Heath,Webster K. Cavenee,Frank B. Furnari,Paul S. Mischel +24 more
TL;DR: Single-cell analyses of patient-derived models and clinical samples from glioblastoma patients treated with EGFR tyrosine kinase inhibitors demonstrate that tumor cells reversibly up-regulate or suppress mutant EGFR expression, conferring distinct cellular phenotypes to reach an optimal equilibrium for growth.
Journal ArticleDOI
Maternal Embryonic Leucine Zipper Kinase Is a Key Regulator of the Proliferation of Malignant Brain Tumors, Including Brain Tumor Stem Cells
Ichiro Nakano,Michael Masterman-Smith,Kuniyasu Saigusa,Andres A. Paucar,Steve Horvath,Lorelei D. Shoemaker,Momoko Watanabe,Alejandra Negro,Ruchi Bajpai,Amy Howes,Vincent Lelievre,James A. Waschek,James A. Waschek,Jorge A. Lazareff,William A. Freije,Linda M. Liau,Richard J. Gilbertson,Timothy F. Cloughesy,Daniel H. Geschwind,Stanley F. Nelson,Paul S. Mischel,Alexey V. Terskikh,Harley I. Kornblum +22 more
TL;DR: A critical role for MELK is demonstrated in the proliferation of brain tumors, including their stem cells, and its expression levels are significantly correlated with shorter survival, particularly in younger glioblastoma patients, suggesting that M ELK may be a compelling molecular target for treatment of high‐grade brain tumors.
Journal ArticleDOI
Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation
Ichiro Nakano,Andres A. Paucar,Ruchi Bajpai,Joseph D. Dougherty,Amani Zewail,Theresa K. Kelly,Kevin J. Kim,Jing Ou,Matthias Groszer,Tetsuya Imura,William A. Freije,Stanley F. Nelson,Michael V. Sofroniew,Hong Wu,Xin Liu,Alexey V. Terskikh,Alexey V. Terskikh,Daniel H. Geschwind,Harley I. Kornblum +18 more
TL;DR: It is shown that MELK serves as a marker for self-renewing multipotent neural progenitors (MNPs) in cultures derived from the developing forebrain and in transgenic mice and is suggested that it regulates the transition from GFAP-expressing progenitor to rapid amplifying progensitors in the postnatal brain.
Journal ArticleDOI
Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Mathew C. Easterday,Joseph D. Dougherty,Robert L. Jackson,Jing Ou,Ichiro Nakano,Andres A. Paucar,Babak Roobini,Mehrnoosh Dianati,Dwain K. Irvin,Irving L. Weissman,Alexey V. Terskikh,Daniel H. Geschwind,Harley I. Kornblum +12 more
TL;DR: Comparison of expression profiles from these stem cell populations indicates that while there is shared gene expression, the amount of genetic overlap is no more than what would be expected by chance, indicating that different stem cells have largely different gene expression patterns.