Andrew B. Gardner

Bio: Andrew B. Gardner is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Ictal & Epilepsy. The author has an hindex of 8, co-authored 11 publications receiving 1144 citations. Previous affiliations of Andrew B. Gardner include Georgia Institute of Technology.

High-frequency oscillations in human temporal lobe : simultaneous microwire and clinical macroelectrode recordings

Abstract: Neuronal oscillations span a wide range of spatial and temporal scales that extend beyond traditional clinical EEG. Recent research suggests that high-frequency oscillations (HFO), in the ripple (80-250 Hz) and fast ripple (250-1000 Hz) frequency range, may be signatures of epileptogenic brain and involved in the generation of seizures. However, most research investigating HFO in humans comes from microwire recordings, whose relationship to standard clinical intracranial EEG (iEEG) has not been explored. In this study iEEG recordings (DC - 9000 Hz) were obtained from human medial temporal lobe using custom depth electrodes containing both microwires and clinical macroelectrodes. Ripple and fast-ripple HFO recorded from both microwires and clinical macroelectrodes were increased in seizure generating brain regions compared to control regions. The distribution of HFO frequencies recorded from the macroelectrodes was concentrated in the ripple frequency range, compared to a broad distribution of HFO frequencies recorded from microwires. The average frequency of ripple HFO recorded from macroelectrodes was lower than that recorded from microwires (143.3 +/- 49.3 Hz versus 116.3 +/- 38.4, Wilcoxon rank sum P<0.0001). Fast-ripple HFO were most often recorded on a single microwire, supporting the hypothesis that fast-ripple HFO are primarily generated by highly localized, sub-millimeter scale neuronal assemblies that are most effectively sampled by microwire electrodes. Future research will address the clinical utility of these recordings for localizing epileptogenic networks and understanding seizure generation.

One-Class Novelty Detection for Seizure Analysis from Intracranial EEG

Abstract: This paper describes an application of one-class support vector machine (SVM) novelty detection for detecting seizures in humans. Our technique maps intracranial electroencephalogram (EEG) time series into corresponding novelty sequences by classifying short-time, energy-based statistics computed from one-second windows of data. We train a classifier on epochs of interictal (normal) EEG. During ictal (seizure) epochs of EEG, seizure activity induces distributional changes in feature space that increase the empirical outlier fraction. A hypothesis test determines when the parameter change differs significantly from its nominal value, signaling a seizure detection event. Outputs are gated in a .one-shot. manner using persistence to reduce the false alarm rate of the system. The detector was validated using leave-one-out cross-validation (LOO-CV) on a sample of 41 interictal and 29 ictal epochs, and achieved 97.1% sensitivity, a mean detection latency of -7.58 seconds, and an asymptotic false positive rate (FPR) of 1.56 false positives per hour (Fp/hr). These results are better than those obtained from a novelty detection technique based on Mahalanobis distance outlier detection, and comparable to the performance of a supervised learning technique used in experimental implantable devices (Echauz et al., 2001). The novelty detection paradigm overcomes three significant limitations of competing methods: the need to collect seizure data, precisely mark seizure onset and offset times, and perform patient-specific parameter tuning for detector training.

A stochastic framework for evaluating seizure prediction algorithms using hidden Markov models.

Abstract: Responsive, implantable stimulation devices to treat epilepsy are now in clinical trials. New evidence suggests that these devices may be more effective when they deliver therapy before seizure onset. Despite years of effort, prospective seizure prediction, which could improve device performance, remains elusive. In large part, this is explained by lack of agreement on a statistical framework for modeling seizure generation and a method for validating algorithm performance. We present a novel stochastic framework based on a three-state hidden Markov model (HMM) (representing interictal, preictal, and seizure states) with the feature that periods of increased seizure probability can transition back to the interictal state. This notion reflects clinical experience and may enhance interpretation of published seizure prediction studies. Our model accommodates clipped EEG segments and formalizes intuitive notions regarding statistical validation. We derive equations for type I and type II errors as a function of the number of seizures, duration of interictal data, and prediction horizon length and we demonstrate the model's utility with a novel seizure detection algorithm that appeared to predicted seizure onset. We propose this framework as a vital tool for designing and validating prediction algorithms and for facilitating collaborative research in this area.

Principles of Neural Science

Abstract: I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Toward machine emotional intelligence: analysis of affective physiological state

Abstract: The ability to recognize emotion is one of the hallmarks of emotional intelligence, an aspect of human intelligence that has been argued to be even more important than mathematical and verbal intelligences. This paper proposes that machine intelligence needs to include emotional intelligence and demonstrates results toward this goal: developing a machine's ability to recognize the human affective state given four physiological signals. We describe difficult issues unique to obtaining reliable affective data and collect a large set of data from a subject trying to elicit and experience each of eight emotional states, daily, over multiple weeks. This paper presents and compares multiple algorithms for feature-based recognition of emotional state from this data. We analyze four physiological signals that exhibit problematic day-to-day variations: The features of different emotions on the same day tend to cluster more tightly than do the features of the same emotion on different days. To handle the daily variations, we propose new features and algorithms and compare their performance. We find that the technique of seeding a Fisher Projection with the results of sequential floating forward search improves the performance of the Fisher Projection and provides the highest recognition rates reported to date for classification of affect from physiology: 81 percent recognition accuracy on eight classes of emotion, including neutral.

Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning

Abstract: Sharp wave ripples (SPW-Rs) represent the most synchronous population pattern in the mammalian brain. Their excitatory output affects a wide area of the cortex and several subcortical nuclei. SPW-Rs occur during "off-line" states of the brain, associated with consummatory behaviors and non-REM sleep, and are influenced by numerous neurotransmitters and neuromodulators. They arise from the excitatory recurrent system of the CA3 region and the SPW-induced excitation brings about a fast network oscillation (ripple) in CA1. The spike content of SPW-Rs is temporally and spatially coordinated by a consortium of interneurons to replay fragments of waking neuronal sequences in a compressed format. SPW-Rs assist in transferring this compressed hippocampal representation to distributed circuits to support memory consolidation; selective disruption of SPW-Rs interferes with memory. Recently acquired and pre-existing information are combined during SPW-R replay to influence decisions, plan actions and, potentially, allow for creative thoughts. In addition to the widely studied contribution to memory, SPW-Rs may also affect endocrine function via activation of hypothalamic circuits. Alteration of the physiological mechanisms supporting SPW-Rs leads to their pathological conversion, "p-ripples," which are a marker of epileptogenic tissue and can be observed in rodent models of schizophrenia and Alzheimer's Disease. Mechanisms for SPW-R genesis and function are discussed in this review.