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Andrew D. Carothers
Researcher at Western General Hospital
Publications - 90
Citations - 6286
Andrew D. Carothers is an academic researcher from Western General Hospital. The author has contributed to research in topics: Population & Inbreeding. The author has an hindex of 40, co-authored 90 publications receiving 6153 citations. Previous affiliations of Andrew D. Carothers include University of Edinburgh.
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Journal ArticleDOI
Association within a family of a balanced autosomal translocation with major mental illness
D St Clair,Douglas Blackwood,Walter J. Muir,M. Walker,Andrew D. Carothers,G. Spowart,C.M. Gosden,H.J. Evans +7 more
TL;DR: The findings suggest that the q21-22 region of chromosome 11 may be a promising area to examine for genes predisposing to major mental illness.
Journal ArticleDOI
Cancer Risk Associated with Germline DNA Mismatch Repair Gene Mutations
Malcolm G. Dunlop,Susan M. Farrington,Susan M. Farrington,Andrew D. Carothers,Andrew H. Wyllie,Linda Sharp,John Burn,Bo Liu,Kenneth W. Kinzler,Bert Vogelstein,Bert Vogelstein +10 more
TL;DR: A systematic approach to identifying individuals at high risk of cancer but who may not be part of classical HNPCC families is demonstrated and a rational basis on which to guide genetic counselling and to tailor clinical surveillance is provided.
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Population choice in mapping genes for complex diseases.
TL;DR: It is argued that the choice of study population is a critical factor when designing a study, and that genetically simplified isolates are more useful than diverse continental populations under most assumptions.
Journal ArticleDOI
The Asp84Glu Variant of the Melanocortin 1 Receptor (MC1R) is Associated with Melanoma
Paloma Valverde,Eugene Healy,Stephen Sikkink,Faye Haldane,Anthony J. Thody,Andrew D. Carothers,Ian J. Jackson,Jonathan L. Rees +7 more
TL;DR: Variants of the MC1R gene are likely to be causally associated with the development of melanoma, and the Asp84Glu variant was only present in melanoma cases and appears to be of particular significance.
Journal ArticleDOI
Cognitive change and the APOE e4 allele
Ian J. Deary,Martha C. Whiteman,Alison Pattie,John M. Starr,Caroline Hayward,Alan F. Wright,Andrew D. Carothers,Lawrence J. Whalley +7 more
TL;DR: This article found that the variation in non-pathological cognitive change from age 11 to 80 is related to their apolipoprotein E (APOE) genotype, which may be mediated by a mechanism that is at least partly independent of its predisposing effect towards Alzheimer's disease.