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Andrew D. Howard
Researcher at Merck & Co.
Publications - 127
Citations - 17799
Andrew D. Howard is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 57, co-authored 127 publications receiving 16846 citations. Previous affiliations of Andrew D. Howard include National Institute for Medical Research.
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Journal ArticleDOI
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Nancy A. Thornberry,Herbert G. Bull,Jimmy R. Calaycay,Kevin T. Chapman,Andrew D. Howard,Matthew J. Kostura,Douglas K. Miller,Susan M. Molineaux,Jeffrey R. Weidner,John G. Aunins,Keith O. Elliston,Julia M. Ayala,Francesca J. Casano,Jayne Chin,Gloria J.-F. Ding,Linda A. Egger,Erin P. Gaffney,Guadalupe A. Limjuco,Oksana C. Palyha,S.M. Raju,Anna M. Rolando,J. Paul Salley,Ting-Ting Yamin,Terry D. Lee,John E. Shively,Malcolm MacCross,Richard A. Mumford,John A. Schmidt,Michael J. Tocci +28 more
TL;DR: Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis.
Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.
Journal ArticleDOI
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.
Xiao-Ming Guan,Hong Yu,Oksana C. Palyha,Karen K. McKee,Scott D. Feighner,Dalip J. S. Sirinathsinghji,Roy G. Smith,Lex H.T. Van der Ploeg,Andrew D. Howard +8 more
TL;DR: The demonstration of hypothalamic and pituitary localization of the GHS-R is consistent with its role in regulating growth hormone release and the expression of the receptor in other central and peripheral regions may implicate its involvement in additional as yet undefined physiological functions.
Journal ArticleDOI
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein.
Howard Y. Chen,Myrna E. Trumbauer,Airu S. Chen,Drew T. Weingarth,J. R. Adams,Easter G. Frazier,Zhu Shen,Donald J. Marsh,Scott D. Feighner,Xiao-Ming Guan,Zhixiong Ye,Ravi P. Nargund,Roy G. Smith,L. H. T. Van Der Ploeg,Andrew D. Howard,Douglas J. MacNeil,Su Qian +16 more
TL;DR: The results establish an in vivo orexigenic function for NPY and AgRP, mediating the effect of ghrelin, as well as the involvement of the melanocortin pathway inghrelin signaling.
Journal ArticleDOI
Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
Maria A. Bednarek,Scott D. Feighner,Sheng-Shung Pong,Karen K. McKee,Donna L. Hreniuk,M V Silva,Vivien A. Warren,Andrew D. Howard,L. H. T. Van Der Ploeg,J V Heck +9 more
TL;DR: The entire sequence of ghrelin is not necessary for activity: the Gly-Ser-Ser(n-octanoyl)-Phe segment appears to constitute the "active core" required for agonist potency at hGHSR1a.