A
Andrew D. Yurochko
Researcher at LSU Health Sciences Center Shreveport
Publications - 55
Citations - 2909
Andrew D. Yurochko is an academic researcher from LSU Health Sciences Center Shreveport. The author has contributed to research in topics: Human cytomegalovirus & Monocyte. The author has an hindex of 28, co-authored 48 publications receiving 2563 citations. Previous affiliations of Andrew D. Yurochko include State University of New York Upstate Medical University & Louisiana State University.
Papers
More filters
Journal ArticleDOI
DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses
TL;DR: It is shown that DC-SIGN and L-SIGN can function as attachment receptors for Sindbis (SB) virus, an arbovirus of the Alphavirus genus, and a cell line has been identified that can productively replicate alphaviruses but is deficient in attachment receptors.
Journal ArticleDOI
Human Cytomegalovirus Induces Monocyte Differentiation and Migration as a Strategy for Dissemination and Persistence
TL;DR: It is reported that primary HCMV infection of monocytes induces transendothelial migration and monocyte-to-macrophage differentiation and that these HCMVs-differentiated macrophages are productive for viral replication.
Journal ArticleDOI
Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage
TL;DR: Overall, the results identify that the HCMV-infected monocyte transcriptome displayed a unique M1/M2 polarization signature that was skewed toward the classical M1 activation phenotype.
Journal ArticleDOI
Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility
TL;DR: Examination of the expression of the epidermal growth factor receptor on the surface of human peripheral blood monocytes but not on other blood leukocyte populations provides evidence that EGFR plays an essential role in the immunopathobiology of HCMV by mediating viral entry into monocytes and stimulating the aberrant biological activity that promotes hematogenous dissemination.
Journal ArticleDOI
Activation of the NF-κB Pathway in Human Cytomegalovirus-Infected Cells Is Necessary for Efficient Transactivation of the Major Immediate-Early Promoter
TL;DR: The results of these studies suggest that virus-mediated NF-κB activation, through the dysregulation of the IKK complex, plays a primary role in the initiation of the HCMV gene cascade in fibroblasts and may provide new targets for therapeutic intervention.