Author
Andrew Hunter
Bio: Andrew Hunter is an academic researcher. The author has contributed to research in topics: Creatine & Creatinine. The author has an hindex of 1, co-authored 1 publications receiving 119 citations.
Topics: Creatine, Creatinine
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TL;DR: A comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism is presented, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inherent implications for physiology and human pathology.
Abstract: The goal of this review is to present a comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis an...
2,332 citations
TL;DR: Total chromogen, true, and AutoAnalyzer methods of measuring serum and urine creatinine by the Jaffe reaction were investigated and their precision, recovery, and sample stability determined.
Abstract: Total chromogen, true, and AutoAnalyzer methods of measuring serum and urine creatinine by the Jaffe reaction were investigated. Some factors influencing this reaction were examined. These included wavelength, blank, linearity, and conditions of color development. Modifications of the three methods were made and their precision, recovery, and sample stability determined. The interference of ketones and glucose were measured. Finally, the values obtained by the three methods on the same samples of serum and urine were compared statistically.
393 citations
TL;DR: Data provide the first evidence of a direct link between extent of phosphorylation of these proteins at sites recognized by the antibodies and activity of the enzymes in electrically stimulated muscle and in muscle of rats running on the treadmill.
Abstract: AMP-activated protein kinase (AMPK) is activated during muscle contraction in response to the increase in AMP and decrease in phosphocreatine (PCr). Once activated, AMPK has been proposed to phosph...
316 citations
22 Nov 2006
269 citations
TL;DR: By serial daily creatinine analyses over long experimental periods on a metabolic ward, "timing" artifact in 24 hour collections was minimized; this is an important source of error if single 24 hour or random samples are used.
Abstract: In general, rates of addition of creatine to and loss of creatinine from the precursor pool depend upon the dietary intake and synthesis of creatine and the conversions of phosphoryl creatine and creatine to creatinine. Meat in a usual diet can appreciably expand the pool because of the slow turnovers of the precursors. Thus, 24 hour urinary creatinine contains a component from that day's turnover of stored creatine ingested previously. During this study, ingestion of creatine and creatinine free, but adequate protein diets, adjusted pool size toward supply and demand and lowered creatinine excretion as much as 30 per cent. For any population, correlation coefficients between estimates of body size or metabolically effective tissue and urinary creatinine depend in part on the expansion of the precursor pool. By serial daily creatinine analyses over long experimental periods on a metabolic ward, "timing" artifact in 24 hour collections was minimized; this is an important source of error if single 24 hour or random samples are used.
171 citations