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Andrew J. Macpherson
Researcher at University of Bern
Publications - 170
Citations - 25031
Andrew J. Macpherson is an academic researcher from University of Bern. The author has contributed to research in topics: Immune system & Immunoglobulin A. The author has an hindex of 56, co-authored 148 publications receiving 20529 citations. Previous affiliations of Andrew J. Macpherson include McMaster University Medical Centre & University Hospital of Bern.
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Journal ArticleDOI
Interactions between the microbiota and the immune system.
TL;DR: Advances in understanding of the interactions between resident microbes and the immune system are reviewed and the implications for human health are reviewed.
Journal ArticleDOI
Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity
Janet Markle,Daniel N. Frank,Steven M. Mortin-Toth,Charles E. Robertson,Leah M. Feazel,Ulrike Rolle-Kampczyk,Martin von Bergen,Kathy D. McCoy,Andrew J. Macpherson,Jayne S. Danska +9 more
TL;DR: It is demonstrated that early-life microbial exposures determine sex hormone levels and modify progression to autoimmunity in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), and Colonization by commensal microbes elevated serum testosterone and protected NOD males from T1D.
Journal ArticleDOI
Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria
Andrew J. Macpherson,Therese Uhr +1 more
TL;DR: It is shown that, even though commensal bacteria are rapidly killed by macrophages, intestinal dendritic cells (DCs) can retain small numbers of live commensals for several days, which allows DCs to selectively induce IgA, which helps protect against mucosal penetration by Commensals.
Journal ArticleDOI
Immune adaptations that maintain homeostasis with the intestinal microbiota
TL;DR: The unique adaptations of the intestinal immune system that maintain homeostatic interactions with a diverse resident microbiota are discussed.
Journal ArticleDOI
Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
Jochen Hampe,Andrew P. Cuthbert,Peter J. P. Croucher,Muddassar M. Mirza,Silvia Mascheretti,Sheila A. Fisher,Henning Frenzel,Katherine S. King,Anja Hasselmeyer,Andrew J. Macpherson,Stephen Bridger,Sander J. H. van Deventer,Alastair Forbes,Susanna Nikolaus,John E. Lennard-Jones,Ulrich R. Foelsch,Michael Krawczak,Cathryn M. Lewis,Stefan Schreiber,Christopher G. Mathew +19 more
TL;DR: The insertion mutation in the NOD2 gene confers a substantially increased susceptibility to Crohn's disease but not to ulcerative colitis.