Author
Andrew J. Martin
Other affiliations: University of Western Australia, Max Planck Society, Victoria University of Wellington ...read more
Bio: Andrew J. Martin is an academic researcher from University of New South Wales. The author has contributed to research in topics: Academic achievement & Medicine. The author has an hindex of 84, co-authored 819 publications receiving 36203 citations. Previous affiliations of Andrew J. Martin include University of Western Australia & Max Planck Society.
Papers published on a yearly basis
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TL;DR: Pravastatin therapy reduced mortality from coronary heart disease and overall mortality, as compared with the rates in the placebo group, as well as the incidence of all prespecified cardiovascular events in patients with a history of myocardial infarction or unstable angina who had a broad range of initial cholesterol levels.
Abstract: Background In patients with coronary heart disease and a broad range of cholesterol levels, cholesterol-lowering therapy reduces the risk of coronary events, but the effects on mortality from coronary heart disease and overall mortality have remained uncertain.
5,215 citations
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TL;DR: Antigen-contacting propensities are presented for each antibody residue, allowing a new definition for the complementarity determining regions (CDRs) to be proposed based on observed antigen contacts.
1,900 citations
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TL;DR: Results from the ‘climateprediction.net’ experiment are presented, the first multi-thousand-member grand ensemble of simulations using a general circulation model and thereby explicitly resolving regional details, finding model versions as realistic as other state-of-the-art climate models but with climate sensitivities ranging from less than 2 K to more than 11’K.
Abstract: In the climateprediction.net project, thousands of individuals have volunteered spare computing capacity on their PCs to help quantify uncertainty in the way our climate responds to increasing levels of greenhouse gases. By running a state-of-the-art climate model thousands of times, it is possible to find out how the model responds to slight changes in the approximations of physical processes that cannot be calculated explicitly. The first batch of results has now been analysed, and surface temperature changes in simulations that capture the climate realistically are ranging from below 2 °C to more than 11 °C. These represent the possible long-term change, averaged over the whole planet, as a result of doubling the levels of atmospheric carbon dioxide in the model. This is the first time that complex models have been found with such a wide range of responses. Their existence will help in quantifying the risks associated with climate change on a regional level. The range of possibilities for future climate evolution1,2,3 needs to be taken into account when planning climate change mitigation and adaptation strategies. This requires ensembles of multi-decadal simulations to assess both chaotic climate variability and model response uncertainty4,5,6,7,8,9. Statistical estimates of model response uncertainty, based on observations of recent climate change10,11,12,13, admit climate sensitivities—defined as the equilibrium response of global mean temperature to doubling levels of atmospheric carbon dioxide—substantially greater than 5 K. But such strong responses are not used in ranges for future climate change14 because they have not been seen in general circulation models. Here we present results from the ‘climateprediction.net’ experiment, the first multi-thousand-member grand ensemble of simulations using a general circulation model and thereby explicitly resolving regional details15,16,17,18,19,20,21. We find model versions as realistic as other state-of-the-art climate models but with climate sensitivities ranging from less than 2 K to more than 11 K. Models with such extreme sensitivities are critical for the study of the full range of possible responses of the climate system to rising greenhouse gas levels, and for assessing the risks associated with specific targets for stabilizing these levels.
1,173 citations
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University of Sydney1, Guy's and St Thomas' NHS Foundation Trust2, University of British Columbia3, Harvard University4, Monash University5, Royal Prince Alfred Hospital6, St. Vincent's Health System7, Garvan Institute of Medical Research8, Auckland City Hospital9, Sydney Adventist Hospital10, Mater Misericordiae University Hospital11, University College Dublin12, University of Alberta13, University of Adelaide14, Queen's University15, Ottawa Hospital Research Institute16, University of Ottawa17, University of Melbourne18, Royal Adelaide Hospital19, Royal Cornwall Hospital20
TL;DR: Enzalutamide was associated with significantly longer progression-free and overall survival than standard care in men with metastatic, hormone-sensitive prostate cancer receiving testosterone suppression.
Abstract: Background Enzalutamide, an androgen-receptor inhibitor, has been associated with improved overall survival in men with castration-resistant prostate cancer. It is not known whether adding enzalutamide to testosterone suppression, with or without early docetaxel, will improve survival in men with metastatic, hormone-sensitive prostate cancer. Methods In this open-label, randomized, phase 3 trial, we assigned patients to receive testosterone suppression plus either open-label enzalutamide or a standard nonsteroidal antiandrogen therapy (standard-care group). The primary end point was overall survival. Secondary end points included progression-free survival as determined by the prostate-specific antigen (PSA) level, clinical progression-free survival, and adverse events. Results A total of 1125 men underwent randomization; the median follow-up was 34 months. There were 102 deaths in the enzalutamide group and 143 deaths in the standard-care group (hazard ratio, 0.67; 95% confidence interval [CI], 0.52 to 0.86; P = 0.002). Kaplan-Meier estimates of overall survival at 3 years were 80% (based on 94 events) in the enzalutamide group and 72% (based on 130 events) in the standard-care group. Better results with enzalutamide were also seen in PSA progression-free survival (174 and 333 events, respectively; hazard ratio, 0.39; P Conclusions Enzalutamide was associated with significantly longer progression-free and overall survival than standard care in men with metastatic, hormone-sensitive prostate cancer receiving testosterone suppression. The enzalutamide group had a higher incidence of seizures and other toxic effects, especially among those treated with early docetaxel. (Funded by Astellas Scientific and Medical Affairs and others; ENZAMET (ANZUP 1304) ANZCTR number, ACTRN12614000110684; ClinicalTrials.gov number, NCT02446405; and EU Clinical Trials Register number, 2014-003190-42.).
865 citations
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TL;DR: In this article, the role of interpersonal relationships in students' academic motivation, engagement, and achievement is discussed, and a tri-level framework is proposed as an integrative and relationally based response to enhance students' motivation and engagement.
Abstract: In this review, we scope the role of interpersonal relationships in students’ academic motivation, engagement, and achievement. We argue that achievement motivation theory, current issues, and educational practice can be conceptualized in relational terms. Influential theorizing, including attribution theory, expectancy-value theory, goal theory, self-determination theory, self-efficacy theory, and self-worth motivation theory, is reviewed in the context of the role of significant others in young people’s academic lives. Implications for educational practice are examined in the light of these theoretical perspectives and their component constructs and mechanisms. A trilevel framework is proposed as an integrative and relationally based response to enhance students’ motivation, engagement, and achievement. This framework encompasses student-level action (universal programs and intervention, targeted programs for at-risk populations, extracurricular activity, cooperative learning, and mentoring), teacher- a...
856 citations
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01 Jan 2016
TL;DR: The using multivariate statistics is universally compatible with any devices to read, allowing you to get the most less latency time to download any of the authors' books like this one.
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14,604 citations
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9,362 citations
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9,185 citations
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TL;DR: Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk S2 The goals of the …
Abstract: Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk S2
The goals of the …
7,184 citations