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Andrew J McArdle
Researcher at Imperial College London
Publications - 8
Citations - 304
Andrew J McArdle is an academic researcher from Imperial College London. The author has contributed to research in topics: Inflammation & Proteome. The author has an hindex of 4, co-authored 8 publications receiving 89 citations. Previous affiliations of Andrew J McArdle include Imperial College Healthcare & St George's Hospital.
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Journal ArticleDOI
Treatment of Multisystem Inflammatory Syndrome in Children.
Andrew J McArdle,Ortensia Vito,Harsita Patel,Eleanor G. Seaby,Priyen Shah,Clare Wilson,Claire Broderick,Ruud G. Nijman,Adriana H Tremoulet,Daniel Munblit,Rolando Ulloa-Gutierrez,Michael J. Carter,Tisham De,CJ Hoggart,Elizabeth Whittaker,Jethro A Herberg,Myrsini Kaforou,Aubrey J. Cunnington,Michael Levin +18 more
TL;DR: In this article, the authors performed an international observational cohort study of clinical and outcome data regarding suspected multisystem inflammatory syndrome (MIS-C) that had been uploaded by physicians onto a Web-based database.
Journal ArticleDOI
When do co-infections matter?
TL;DR: There are already tantalizing examples where identification and treatment of relevant co-infections seems to hold promise for improved health outcomes, and tackling these challenges, using animal models, or careful prospective studies in humans may prove to be worthwhile.
Journal ArticleDOI
Determinants of Carboxyhemoglobin Levels and Relationship with Sepsis in a Retrospective Cohort of Preterm Neonates.
Andrew J McArdle,James Webbe,Kathleen Sim,Graham Parrish,Clive J. Hoggart,Yifei Wang,J. Simon Kroll,J. Simon Kroll,Sunit Godambe,Sunit Godambe,Aubrey J. Cunnington,Aubrey J. Cunnington +11 more
TL;DR: The results show that carboxyhemoglobin is unlikely to be a clinically useful biomarker of sepsis in premature infants, and raise a note of caution about factors which may confound the use of carbon monoxide as a clinical biomarker for other disease processes such as hemolysis.
Journal ArticleDOI
Sensitivity of shotgun metagenomics to host DNA: abundance estimates depend on bioinformatic tools and contamination is the main issue.
Andrew J McArdle,Myrsini Kaforou +1 more
TL;DR: It is concluded that read binning tools can remain sensitive to low-abundance organisms even with high host DNA content, but even low levels of contamination pose a significant problem due to low microbial biomass.
Journal ArticleDOI
What is proteomics
TL;DR: This work aims to introduce the complex field of proteomics to paediatricians and present some recent examples of applications to paediatrics, and describes the experimental and computational approach.