A
Andrew J. Schork
Researcher at Lundbeck
Publications - 133
Citations - 12414
Andrew J. Schork is an academic researcher from Lundbeck. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 38, co-authored 107 publications receiving 9278 citations. Previous affiliations of Andrew J. Schork include University of Copenhagen & University of California, San Diego.
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Journal ArticleDOI
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
F. Kyle Satterstrom,F. Kyle Satterstrom,Jack A. Kosmicki,Jiebiao Wang,Michael S. Breen,Silvia De Rubeis,Joon Yong An,Joon Yong An,Minshi Peng,Ryan Collins,Jakob Grove,Jakob Grove,Lambertus Klei,Christine Stevens,Jennifer Reichert,Maureen Mulhern,Mykyta Artomov,Sherif Gerges,Brooke Sheppard,Xinyi Xu,Aparna Bhaduri,Utku Norman,Harrison Brand,Grace Schwartz,Rachel Nguyen,Elizabeth E. Guerrero,Caroline Dias,Branko Aleksic,Richard Anney,Mafalda Barbosa,Somer L. Bishop,Alfredo Brusco,Jonas Bybjerg-Grauholm,Angel Carracedo,Marcus C.Y. Chan,Andreas G. Chiocchetti,Brian H.Y. Chung,Hilary Coon,Michael L. Cuccaro,Aurora Currò,Bernardo Dalla Bernardina,Ryan N. Doan,Enrico Domenici,Shan Dong,Chiara Fallerini,Montserrat Fernández-Prieto,Giovanni Battista Ferrero,Christine M. Freitag,Menachem Fromer,J. Jay Gargus,Daniel H. Geschwind,Elisa Giorgio,Javier González-Peñas,Stephen J. Guter,Danielle Halpern,Emily Hansen-Kiss,Xin He,Gail E. Herman,Irva Hertz-Picciotto,David M. Hougaard,Christina M. Hultman,Iuliana Ionita-Laza,Suma Jacob,Jesslyn Jamison,Astanand Jugessur,Miia Kaartinen,Gun Peggy Knudsen,Alexander Kolevzon,Itaru Kushima,So Lun Lee,Terho Lehtimäki,Elaine T. Lim,Carla Lintas,W. Ian Lipkin,Diego Lopergolo,Fátima Lopes,Yunin Ludena,Patrícia Maciel,Per Magnus,Behrang Mahjani,Nell Maltman,Dara S. Manoach,Gal Meiri,Idan Menashe,Judith Miller,Nancy J. Minshew,Eduarda Montenegro M. de Souza,Danielle de Paula Moreira,Eric M. Morrow,Ole Mors,Preben Bo Mortensen,Matthew W. Mosconi,Pierandrea Muglia,Benjamin M. Neale,Merete Nordentoft,Norio Ozaki,Aarno Palotie,Mara Parellada,Maria Rita Passos-Bueno,Margaret A. Pericak-Vance,Antonio M. Persico,Isaac N. Pessah,Kaija Puura,Abraham Reichenberg,Alessandra Renieri,Evelise Riberi,Elise B. Robinson,Elise B. Robinson,Kaitlin E. Samocha,Sven Sandin,Sven Sandin,Susan L. Santangelo,Susan L. Santangelo,Gerry Schellenberg,Stephen W. Scherer,Sabine Schlitt,Rebecca J. Schmidt,Lauren M. Schmitt,Isabela Maya Wahys Silva,Tarjinder Singh,Tarjinder Singh,Paige M. Siper,Moyra Smith,Gabriela Soares,Camilla Stoltenberg,Pål Surén,Ezra Susser,John A. Sweeney,Peter Szatmari,Lara Tang,Flora Tassone,Karoline Teufel,Elisabetta Trabetti,Maria del Pilar Trelles,Christopher A. Walsh,Lauren A. Weiss,Thomas Werge,Donna M. Werling,Emilie M. Wigdor,Emilie M. Wigdor,Emma Wilkinson,A. Jeremy Willsey,Timothy W. Yu,Mullin H.C. Yu,Ryan Yuen,Elaine Cristina Zachi,Esben Agerbo,Thomas Damm Als,Vivek Appadurai,Marie Bækvad-Hansen,Rich Belliveau,Alfonso Buil,Caitlin E. Carey,Felecia Cerrato,Kimberly Chambert,Claire Churchhouse,Claire Churchhouse,Søren Dalsgaard,Ditte Demontis,Ashley Dumont,Jacqueline I. Goldstein,Christine Søholm Hansen,Mads E. Hauberg,Mads E. Hauberg,Mads E. Hauberg,Mads V. Hollegaard,Daniel P. Howrigan,Hailiang Huang,Julian Maller,Alicia R. Martin,Joanna Martin,Manuel Mattheisen,Jennifer L. Moran,Jonatan Pallesen,Duncan S. Palmer,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Timothy Poterba,Jesper Buchhave Poulsen,Stephan Ripke,Andrew J. Schork,Wesley K. Thompson,Patrick Turley,Raymond K. Walters,Catalina Betancur,Edwin H. Cook,Louise Gallagher,Michael Gill,James S. Sutcliffe,Audrey Thurm,Michael E. Zwick,Anders D. Børglum,Matthew W. State,A. Ercument Cicek,A. Ercument Cicek,Michael E. Talkowski,David J. Cutler,Bernie Devlin,Stephen Sanders,Kathryn Roeder,Mark J. Daly,Joseph D. Buxbaum +201 more
TL;DR: The largest exome sequencing study of autism spectrum disorder (ASD) to date, using an enhanced analytical framework to integrate de novo and case-control rare variation, identifies 102 risk genes at a false discovery rate of 0.1 or less, consistent with multiple paths to an excitatory-inhibitory imbalance underlying ASD.
Journal ArticleDOI
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture.
Louise C. Laurent,Louise C. Laurent,Igor Ulitsky,Igor Ulitsky,Ileana Slavin,Ha Tran,Andrew J. Schork,Robert Morey,Robert Morey,Candace L. Lynch,Julie V. Harness,Sunray Lee,Maria J. Barrero,Sherman Ku,Marina Martynova,Ruslan Semechkin,Vasiliy Galat,Joel M. Gottesfeld,Juan Carlos Izpisua Belmonte,Charles E. Murry,Hans S. Keirstead,Hyun Sook Park,Uli Schmidt,Andrew L. Laslett,Andrew L. Laslett,Andrew L. Laslett,Franz-Josef Müller,Caroline M. Nievergelt,Ron Shamir,Jeanne F. Loring +29 more
TL;DR: The results illustrate the dynamic nature of genomic abnormalities in pluripotent stem cells and the need for frequent genomic monitoring to assure phenotypic stability and clinical safety.
Journal ArticleDOI
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
Michael J. Gandal,Jillian R. Haney,Neelroop N. Parikshak,Virpi Leppa,Gokul Ramaswami,Christopher Hartl,Andrew J. Schork,Vivek Appadurai,Alfonso Buil,Thomas Werge,Thomas Werge,Thomas Werge,Chunyu Liu,Chunyu Liu,Kevin P. White,Steve Horvath,Daniel H. Geschwind +16 more
TL;DR: A comprehensive systems-level view of the neurobiological architecture of major neuropsychiatric illness demonstrates pathways of molecular convergence and specificity as well as a substantial causal genetic component.
Journal ArticleDOI
Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis
Martine Hoogman,Janita Bralten,Derrek P. Hibar,Maarten Mennes,Marcel P. Zwiers,Lizanne S.J. Schweren,Kimm J. E. van Hulzen,Sarah E. Medland,Elena Shumskaya,Neda Jahanshad,Patrick de Zeeuw,Eszter Szekely,Gustavo Sudre,Thomas Wolfers,Alberdingk M.H. Onnink,Janneke Dammers,Jeanette C. Mostert,Yolanda Vives-Gilabert,Gregor Kohls,Eileen Oberwelland,Jochen Seitz,Martin Schulte-Rüther,Sara Ambrosino,Alysa E. Doyle,Alysa E. Doyle,Marie F. Høvik,Margaretha Dramsdahl,Leanne Tamm,Theo G.M. van Erp,Anders M. Dale,Andrew J. Schork,Annette Conzelmann,Annette Conzelmann,Kathrin C. Zierhut,Ramona Baur,Hazel McCarthy,Yuliya N. Yoncheva,Ana Cubillo,Kaylita Chantiluke,Mitul A. Mehta,Yannis Paloyelis,Sarah Hohmann,Sarah Baumeister,Ivanei E. Bramati,Paulo Mattos,Fernanda Tovar-Moll,Pamela K. Douglas,Tobias Banaschewski,Daniel Brandeis,Jonna Kuntsi,Philip Asherson,Katya Rubia,Clare Kelly,Clare Kelly,Adriana Di Martino,Michael P. Milham,Michael P. Milham,Francisco X. Castellanos,Francisco X. Castellanos,Thomas Frodl,Thomas Frodl,Mariam Zentis,Klaus-Peter Lesch,Klaus-Peter Lesch,Andreas Reif,Paul Pauli,Terry L. Jernigan,Jan Haavik,Jan Haavik,Kerstin J. Plessen,Astri J. Lundervold,Kenneth Hugdahl,Kenneth Hugdahl,Larry J. Seidman,Larry J. Seidman,Joseph Biederman,Nanda Rommelse,Dirk J. Heslenfeld,Catharina A. Hartman,Pieter J. Hoekstra,Jaap Oosterlaan,Georg von Polier,Kerstin Konrad,Oscar Vilarroya,Josep Antoni Ramos-Quiroga,Joan Carles Soliva,Sarah Durston,Jan K. Buitelaar,Stephen V. Faraone,Stephen V. Faraone,Philip Shaw,Paul M. Thompson,Barbara Franke +92 more
TL;DR: Lifespan analyses suggest that, in the absence of well powered longitudinal studies, the ENIGMA cross-sectional sample across six decades of ages provides a means to generate hypotheses about lifespan trajectories in brain phenotypes.
Journal ArticleDOI
HHS Public Access
Martine Hoogman,Janita Bralten,Derrek P. Hibar,Maarten Mennes,Marcel P. Zwiers,Lizanne S.J. Schweren,Kimm J. E. van Hulzen,Sarah E. Medland,Elena Shumskaya,Neda Jahanshad,Patrick de Zeeuw,Eszter Szekely,Gustavo Sudre,Thomas Wolfers,Alberdingk M.H. Onnink,Janneke Dammers,Jeanette C. Mostert,Yolanda Vives-Gilabert,Gregor Kohls,Eileen Oberwelland,Jochen Seitz,Martin Schulte-Rüther,Sara Ambrosino,Alysa E. Doyle,Marie F. Høvik,Margaretha Dramsdahl,Leanne Tamm,Theo G.M. van Erp,Anders M. Dale,Andrew J. Schork,Annette Conzelmann,Kathrin C. Zierhut,Ramona Baur,Hazel McCarthy,Yuliya N. Yoncheva,Ana Cubillo,Kaylita Chantiluke,Mitul A. Mehta,Yannis Paloyelis,Sarah Hohmann,Sarah Baumeister,Ivanei E. Bramati,Paulo Mattos,Fernanda Tovar-Moll,Pamela K. Douglas,Tobias Banaschewski,Daniel Brandeis,Jonna Kuntsi,Philip Asherson,Katya Rubia,Clare Kelly,Adriana Di Martino,Michael P. Milham,Francisco X. Castellanos,Thomas Frodl,Mariam Zentis,Klaus-Peter Lesch,Andreas Reif,Paul Pauli,Terry L. Jernigan,Jan Haavik,Kerstin J. Plessen,Astri J. Lundervold,Kenneth Hugdahl,Larry J. Seidman,Joseph Biederman,Nanda Rommelse,Dirk J. Heslenfeld,Catharina A. Hartman,Pieter J. Hoekstra,Jaap Oosterlaan,Georg von Polier,Kerstin Konrad,Oscar Vilarroya,Josep Antoni Ramos-Quiroga,Joan Carles Soliva,Sarah Durston,Jan K. Buitelaar,Stephen V. Faraone,Philip Shaw,Paul M. Thompson,Barbara Franke,Stephen M. Smith,Thomas E. Nichols,Amy Taylor,Hannah J. Jones,Hannah M Sallis,George Davey Smith,Debbie A Lawlor,Neil Davies,Evie Stergiakouli,Marcus R. Munafò,Jack Euesden,Kate Tilling,Stan Zammit,T. Kubota,K. Miyake,N. Hariya,K. Mochizuki,Keri S. Rosch,Deana Crocetti,Kathryn Hirabayashi,Martha B. Denckla,Stewart H. Mostofsky,E. Mark Mahone,Simon Ducharme,Matthew D. Albaugh,Tuong Vi Nguyen,James J. Hudziak,J. M. Mateos-Pérez,Aurelie Labbe,Alan C. Evans,Sherif Karama,William S. Ball,Anna Weber Byars,Mark Schapiro,Wendy Bommer,April Carr,April German,Scott Dunn,Michael J. Rivkin,Deborah Waber,Robert Mulkern,Sridhar Vajapeyam,Abigail Chiverton,Peter Davis,Julie Koo,Jacki Marmor,Christine Mrakotsky,Richard Robertson,Gloria McAnulty,Michael E. Brandt,Jack M. Fletcher,Larry A. Kramer,Grace Yang,Cara McCormack,Kathleen M. Hebert,Hilda Volero,Kelly Botteron,Robert C. McKinstry,William Warren,Tomoyuki Nishino,C. Robert Almli,Richard Todd,John Constantino,Jennifer Levitt,Jeffry R. Jeffrey Alger,Joseph O'Neil,Arthur W. Toga,Robert Asarnow,David Fadale,Laura Heinichen,Cedric Ireland,Dah Jyuu Wang,Edward Moss,Robert A. Zimmerman,Brooke Bintliff,Ruth Bradford,Janice Newman,Rozalia Arnaoutelis,G. Bruce Pike,D. Louis Collins,Gabriel Leonard,Tomáš Paus,Alex Zijdenbos,Samir Das,Vladimir Fonov,Luke Fu,Jonathan Harlap,Ilana Leppert,Denise Milovan,Dario Vins,Thomas Zeffiro,John Van Meter,Nicholas Lange,Michael P. Froimowitz,Cheryl Rainey,Stan Henderson,Jennifer L. Edwards,Diane Dubois,Karla Smith,Tish Singer,Aaron A. Wilber,Carlo Pierpaoli,Peter J. Basser,Lin Ching Chang,Chen Guan Koay,Lindsay Walker,Lisa Freund,Judith Rumsey,Lauren Baskir,Laurence Stanford,Karen Sirocco,Katrina Gwinn-Hardy,Giovanna Spinella,James T. McCracken,Joseph O'Neill,Helen Brinson,Avijit Banik,Deepika Kandilya,Seshadri Ramya,Walter Stünkel,Yap Seng Chong,S. Thameem Dheen,Yuliya S. Nikolova,Ahmad R. Hariri,Wenjun Zhang,Xiuxia Qu,Biyi Chen,Marylynn Snyder,Baiyan Li,Yue Tang,Hanying Chen,Wuqiang Zhu,Ni Yin,Deqiang Li,Xie Li,Ying Liu,J Jillian,Xin-yuan Fu,Michael Rubart,Long-sheng Song,Weinian Shou,Peking Union Medical,Iowa City,Corinde E. Wiers,Brock Medsker,Erick Forno,Hyagriv Simhan,C Juan,Ravi Bansal,Hongtu Zhu,Ronald Whiteman,Georgette A Quackenbush,Laura Martin,Kathleen Durkin,Jason Royal,Bradley S. Peterson,Martha O Wang,Charlotte E Vorwald,Maureen L Dreher,Eric J Mott,Ali Cinar,Hamidreza Mehdizadeh,Sami Somo,David Dean,Eric M Brey,John P Fisher +247 more