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Andrew John Hollins
Researcher at Cardiff University
Publications - 28
Citations - 1977
Andrew John Hollins is an academic researcher from Cardiff University. The author has contributed to research in topics: Gene silencing & Gene expression. The author has an hindex of 19, co-authored 27 publications receiving 1859 citations. Previous affiliations of Andrew John Hollins include University of Texas Medical Branch.
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Journal ArticleDOI
Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function
Vanessa J. Davies,Andrew John Hollins,Malgorzata Piechota,Wan Fen Yip,Jennifer R. Davies,Kathryn White,Phillip P. Nicols,Michael E. Boulton,Michael E. Boulton,Marcela Votruba +9 more
TL;DR: Findings indicate that the opa1 GTPase contains crucial information required for the survival of RGCs and that Opa1 is essential for early embryonic survival.
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Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells.
Yadollah Omidi,Andrew John Hollins,Mustapha Benboubetra,Ross M. Drayton,Ibrahim F. Benter,Saghir Akhtar +5 more
TL;DR: The fact that inadvertent gene expression changes can be induced by the delivery formulation alone and that these may, ultimately, have important safety implications for the use of these non-viral vectors in gene-based therapies are highlighted.
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Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C
Sabine Fuchs,Andrew John Hollins,Michael Laue,Ulrich F. Schaefer,Klaus Roemer,Mark Gumbleton,Claus-Michael Lehr +6 more
TL;DR: It is suggested that the culture may serve as a suitable model to study epithelial transport or cell biological processes in human alveolar cells to characterize a primary cell culture for in vitro model studying pulmonary drug delivery.
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Polypropylenimine dendrimer-induced gene expression changes: the effect of complexation with DNA, dendrimer generation and cell type.
TL;DR: Data show for the first time that PPI-dendrimers, separate from their capability as transfection reagents, can intrinsically alter the expression of many endogenous genes that could potentially lead to them exerting multiple biological effects in cells.
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Caveolin-1 expression and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures
Lee Campbell,Andrew John Hollins,A. Al-Eid,Geoff R. Newman,Christopher John Von Ruhland,Mark Gumbleton +5 more
TL;DR: It is demonstrated that freshly isolated rat ATII cells lack Caveolae and expression of caveolin-1 (a critical caveolae structural protein) as a function of in vitro transformation from the ATII to the ATI-like phenotype.