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Andrew M. Davis
Researcher at Washington University in St. Louis
Publications - 747
Citations - 27554
Andrew M. Davis is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Chondrite & Medicine. The author has an hindex of 77, co-authored 669 publications receiving 23918 citations. Previous affiliations of Andrew M. Davis include Cornell University & Field Museum of Natural History.
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The Design of Leadlike Combinatorial Libraries.
TL;DR: The optimization of low-potency leads into drugs is often accompanied by an increase in molecular weight and lipophilicity, as a consequence of affinity enhancement, shown schematically by the distributions of M(r) for a leadlike library, oral drugs, and a typical combinatorial chemistry library.
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Is There a Difference between Leads and Drugs? A Historical Perspective
TL;DR: Lead structures exhibit, on the average, less molecular complexity, are less hydrophobic, and less druglike (lower druglike scores), and this information should be used in the design of novel combinatorial libraries that are aimed at lead discovery.
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The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors
Andrew M. Davis,Vaibhav G. Patel +1 more
TL;DR: The findings indicate that PD-L1 expression as a predictive biomarker has limitations and that the decision to pursue testing must be carefully implemented for clinical decision-making.
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The distribution of aluminum-26 in the early Solar System—A reappraisal
TL;DR: In this article, a compilation of over 1500 Mg-isotopic analyses of Al-rich material from primitive solar system matter (meteorites) shows clearly that 26Al existed live in the early Solar System.
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Diabetes and Hypertension: A Position Statement by the American Diabetes Association
Ian H. de Boer,Sripal Bangalore,Athanase Benetos,Andrew M. Davis,Erin D. Michos,Paul Muntner,Peter Rossing,Sophia Zoungas,George L. Bakris +8 more
TL;DR: This Position Statement is intended to update the assessment and treatment of hypertension among people with diabetes, including advances in care since the American Diabetes Association last published a Position Statement on this topic in 2003.