Andrew M. Yuan

TL;DR: The synthesis of three series of dicarboxylic acid dipeptide neutral endopeptidase 24.11 (NEP) inhibitors is described, and the amino butyramide 21a exhibited potent NEP inhibitory activity in vitro and in vivo.

TL;DR: The preparation of a series of 1-glutarylindoline-2(S)-carboxylic acid derivatives, 6a-v and 21a-c, is described and the structure-activity relationship of the series is discussed.

TL;DR: Using TFIT, a novel molecular superimposition program, it was shown that the meta analogs could be readily superimposed onto the authors' ACE inhibitor template whereas no low-energy superimpositions of the ortho-substituted macrocycles could be found.

TL;DR: In normolipidemic rats and dogs, oral administration of 8aR dose-dependently reduced both plasma triglycerides and total cholesterol and hepatic lipid accumulation resulted in negligible change in total liver weight and was reversible after withdrawal of the compound.

TL;DR: The synthesis of N-(3-mercaptopropionyl)-N-arylglycines, N-arylalanines, and -1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids and the in vivo inhibition of ACE and antihypertensive effects of representative compounds from each series are discussed.