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Andrew Neuhauser

Bio: Andrew Neuhauser is an academic researcher from Westerly Hospital. The author has an hindex of 1, co-authored 1 publications receiving 6 citations.

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Journal ArticleDOI
TL;DR: A woman having 2nd trimester maternal serum inhibin A concentration is described, on average, approximately twice as high as in unaffected singleton pregnancies and in pregnancies with complete hydatidiform mole.
Abstract: Maternal serum screening for Down syndrome is commonly performed in the 2nd trimester using α fetoprotein (AFP), unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and inhibin A. Concentrations of each marker are combined with maternal age to calculate a patient-specific risk of fetal Down syndrome. In cases of Down syndrome, inhibin A concentration is, on average, approximately twice as high as in unaffected singleton pregnancies (1). Second trimester maternal serum inhibin A is also increased in twin pregnancies [1.99 multiples of the median (MoM) (1)] and in Turner syndrome with hydrops (3.91 MoM; (2)). Markedly increased inhibin A has been observed in pregnancies with complete hydatidiform mole [4–7 MoM; (3)]. Increased inhibin A may also be seen in nonpregnant women with ovarian cancer (4). We describe a woman having 2nd trimester serum inhibin …

7 citations


Cited by
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Journal ArticleDOI
TL;DR: The simplification of the assay made possible by the improved antibody should make possible a new generation of more rapid, sensitive, convenient and robust tools for routine use.

68 citations

Journal ArticleDOI
TL;DR: Use of the falsely low AFP concentrations to calculate risk of Down's syndrome resulted in significantly increased calculated risk compared with complement depleted results, which is a potential cause of false Down’s syndrome screen positive results.
Abstract: BackgroundFalsely decreased serum alphafetoprotein (AFP) concentrations are reported in the autoDELFIA® hAFP immunoassay due to interference by complement. AFP is measured, using this assay, as part of second-trimester and integrated Down's syndrome screening tests. Decreased AFP concentrations increase the calculated risk of Down's syndrome; therefore falsely low AFP, due to assay interference, may artificially increase a patient's risk, and have the potential to cause false screen positive results. It was our aim to assess whether negative interference in the autoDELFIA® hAFP assay was a cause of very low AFP concentrations, and to examine the effect of falsely decreased concentrations on the calculated risk of Down's syndrome.MethodsThree hundred and twenty-three sequential Down's screening serum samples with very low serum AFP concentration (<15 KU/L) using the autoDELFIA® hAFP immunoassay were selected and AFP re-measured using the E170 AFP immunoassay.ResultsInterference was detected in nine samples...

9 citations

Journal ArticleDOI
TL;DR: It can be concluded that it is possible to reduce environmental exposures affecting hormonal abnormalities among pregnant women by improving nutritional patterns, minimizing the use of pesticides at home, and reducing the intake of canned foods and greenhouse fruits.

5 citations

Journal ArticleDOI
TL;DR: The analytical performance of the Access inhibin A assay is acceptable for routine laboratory testing and may have utility as a serum tumor marker in postmenopausal women with ovarian cancer and men with testicular stromal tumors.

4 citations

Book ChapterDOI
01 Jan 2013
TL;DR: This chapter reviews the interferences and analytical difficulties in measuring hormones using immunoassays.
Abstract: The concentrations of a variety of hormones are measured in the clinical laboratory typically by using immunoassays. These techniques are known to be vulnerable to a number of interferences, for example, heterophilic antibodies and macro-complexes, to name a few. In addition, there are other factors that make these measurements challenging, such as the existence of multiple isoforms of a single hormone and supplemental dietary ingestion of biotin which is a component of many immunoassay systems. This chapter reviews the interferences and analytical difficulties in measuring hormones using immunoassays.

3 citations