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Andrew S. Herbert
Researcher at United States Department of the Army
Publications - 73
Citations - 6185
Andrew S. Herbert is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Ebola virus & Epitope. The author has an hindex of 31, co-authored 66 publications receiving 4503 citations. Previous affiliations of Andrew S. Herbert include Virginia–Maryland Regional College of Veterinary Medicine & Virginia Tech.
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Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
Jan E. Carette,Jan E. Carette,Matthijs Raaben,Anthony C. Wong,Andrew S. Herbert,Gregor Obernosterer,Gregor Obernosterer,Nirupama Mulherkar,Ana I. Kuehne,Philip J. Kranzusch,April M. Griffin,Gordon Ruthel,Paola Dal Cin,John M. Dye,Sean P. J. Whelan,Kartik Chandran,Thijn R. Brummelkamp,Thijn R. Brummelkamp +17 more
TL;DR: It is shown that membrane fusion mediated by filovirus glycoproteins and viral escape from the vesicular compartment require the NPC1 protein, independent of its known function in cholesterol transport, which indicates potential antiviral strategies to combat these deadly agents.
Journal ArticleDOI
Broad neutralization of SARS-related viruses by human monoclonal antibodies.
Anna Z. Wec,Daniel Wrapp,Andrew S. Herbert,Daniel P. Maurer,Denise Haslwanter,Mrunal Sakharkar,Rohit K. Jangra,M. Eugenia Dieterle,Asparouh Lilov,Deli Huang,Longping V. Tse,Nicole V. Johnson,Ching-Lin Hsieh,Nianshuang Wang,Juergen Hermann Nett,Elizabeth Champney,Irina Burnina,Michael G. Brown,Shu Lin,Melanie Sinclair,Carl Hirschie Johnson,Sarat Pudi,Robert H. Bortz,Ariel S. Wirchnianski,Ethan Laudermilch,Catalina Florez,J. Maximilian Fels,Cecilia M. O’Brien,Barney S. Graham,David Nemazee,Dennis R. Burton,Ralph S. Baric,James E. Voss,Kartik Chandran,John M. Dye,Jason S. McLellan,Laura M. Walker +36 more
TL;DR: Hundreds of antibodies against the viral spike protein of SARS-CoV-2 are isolated from the memory B cells of a survivor of the 2003 outbreak and reveal a target for the rational design of pan-sarbecovirus vaccines.
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Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
Kui K. Chan,Danielle Dorosky,Preeti Sharma,Shawn A. Abbasi,John M. Dye,David M. Kranz,Andrew S. Herbert,Erik Procko +7 more
TL;DR: A variant of ACE2 based on deep mutagenesis far outcompetes the natural receptor in binding the SARS-CoV-2 spike protein and gives ACE2 variants with affinities that rival those of monoclonal antibodies.
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Ebola virus entry requires the host-programmed recognition of an intracellular receptor
Emily Happy Miller,Gregor Obernosterer,Matthijs Raaben,Andrew S. Herbert,Maika S. Deffieu,Anuja Krishnan,Esther Ndungo,Rohini G. Sandesara,Jan E. Carette,Ana I. Kuehne,Gordon Ruthel,Suzanne R. Pfeffer,John M. Dye,Sean P. J. Whelan,Thijn R. Brummelkamp,Kartik Chandran +15 more
TL;DR: These findings support a model in which GP cleavage by endosomal cysteine proteases unmasks the binding site for NPC1, and GP–NPC1 engagement within lysosomes promotes a late step in entry proximal to viral escape into the host cytoplasm.
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Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease
John M. Dye,Andrew S. Herbert,Ana I. Kuehne,James F. Barth,Majidat A. Muhammad,Samantha E. Zak,Ramon A. Ortiz,Laura I. Prugar,William D. Pratt +8 more
TL;DR: It is demonstrated that postexposure antibody treatments can protect NHPs and open avenues for filovirus therapies for human use using established Food and Drug Administration-approved polyclonal or monoclonal antibody technologies.