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Andrew S. McNeal
Researcher at University of California, San Francisco
Publications - 13
Citations - 610
Andrew S. McNeal is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Melanoma & Human skin. The author has an hindex of 7, co-authored 12 publications receiving 435 citations. Previous affiliations of Andrew S. McNeal include University of Pennsylvania.
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Journal ArticleDOI
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria
César Cárdenas,Marioly Müller,Andrew S. McNeal,Alenka Lovy,Fabian Jaňa,Galdo Bustos,Félix A. Urra,Natalia Smith,Jordi Molgó,J. Alan Diehl,Todd W. Ridky,J. Kevin Foskett +11 more
TL;DR: It is demonstrated that tumorigenic cancer cell lines, transformed primary human fibroblasts, and tumors in vivo respond similarly but that autophagy is insufficient for survival, and cancer cells die while their normal counterparts are spared.
Journal ArticleDOI
Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation.
Hanlin Zeng,Aparna Jorapur,A. Hunter Shain,Ursula E. Lang,Rodrigo Torres,Yuntian Zhang,Andrew S. McNeal,Thomas Botton,Jue Lin,Matthew Donne,Ingmar N. Bastian,Richard Yu,Jeffrey P. North,Laura B. Pincus,Beth S. Ruben,Beth S. Ruben,Nancy M. Joseph,Iwei Yeh,Boris C. Bastian,Robert L. Judson +19 more
TL;DR: A mechanism by which CDKN2A suppresses the initiation of melanoma invasion through inhibition of BRN2 is demonstrated, which is downstream of CDKN1 and directly regulated by E2F1.
Journal ArticleDOI
CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma
Andrew S. McNeal,Kevin Liu,Vihang Nakhate,Christopher A. Natale,Elizabeth K. Duperret,Brian C. Capell,Tzvete Dentchev,Shelley L. Berger,Meenhard Herlyn,John T. Seykora,Todd W. Ridky +10 more
TL;DR: It is shown that CDKN2B is highly upregulated in benign melanocytic nevi, contributes to maintaining nevus melanocytes in a growth-arrested premalignant state, and is commonly lost in melanoma.
Journal ArticleDOI
Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus
Katie A. Howell,Jennifer M. Brannan,Christopher Bryan,Andrew S. McNeal,Edgar Davidson,Hannah L. Turner,Hong Vu,Sergey Shulenin,Shihua He,Shihua He,Ana I. Kuehne,Andrew S. Herbert,Xiangguo Qiu,Xiangguo Qiu,Benjamin J. Doranz,Frederick W. Holtsberg,Andrew B. Ward,John M. Dye,M. Javad Aman +18 more
TL;DR: It is found that a hotspot for the binding of these enabling antibody pairs near the interface of the glycan cap and GP2 may be an underappreciated phenomenon for viruses, with implications for the design and development of immunotherapeutics and vaccines.
Journal ArticleDOI
The genomic landscapes of individual melanocytes from human skin.
Jessica A. Tang,Eleanor Fewings,Darwin Chang,Hanlin Zeng,Shanshan Liu,Aparna Jorapur,R.L. Belote,R.L. Belote,Andrew S. McNeal,Tuyet M. Tan,Iwei Yeh,Sarah T. Arron,Robert L. Judson-Torres,Robert L. Judson-Torres,Boris C. Bastian,A. Hunter Shain +15 more
TL;DR: The results uncover the genomic landscapes of individual melanocytes, providing key insights into the causes and origins of melanoma.