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Andrew Sommerlad

Bio: Andrew Sommerlad is an academic researcher from University College London. The author has contributed to research in topics: Dementia & Medicine. The author has an hindex of 18, co-authored 51 publications receiving 4671 citations. Previous affiliations of Andrew Sommerlad include National Health Service & Camden and Islington NHS Foundation Trust.

Papers published on a yearly basis

Papers
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Journal ArticleDOI
TL;DR: The Lancet Commission on Dementia Prevention, Intervention, and Care met to consolidate the huge strides that have been made and the emerging knowledge as to what the authors should do to prevent and manage dementia.

3,826 citations

Journal ArticleDOI
TL;DR: Author(s): Livingston, Gill; Huntley, Jonathan; Sommerlad, Andrew ; Sommer Glad, Andrew; Ames, David; Ballard, Clive; Banerjee, Sube; Brayne, Carol; Burns, Alistair; Cohen-Mansfield, Jiska; Cooper, Claudia; Costafreda, Sergi G; Dias, Amit; Fox, Nick; Gitlin, Laura N; Howard, Robert; Kales, Helen C;

3,559 citations

Journal ArticleDOI
TL;DR: Diabetes increased the risk of conversion to dementia and other prognostic factors that are potentially manageable are prediabetes and the metabolic syndrome, neuropsychiatric symptoms, and low dietary folate.
Abstract: Objective:Public health campaigns encouraging early help seeking have increased rates of mild cognitive impairment (MCI) diagnosis in Western countries, but we know little about how to treat or predict dementia outcomes in persons with the condition.Method:The authors searched electronic databases and references for longitudinal studies reporting potentially modifiable risk factors for incident dementia after MCI. Two authors independently evaluated study quality using a checklist. Meta-analyses were conducted of three or more studies.Results:There were 76 eligible articles. Diabetes and prediabetes increased risk of conversion from amnestic MCI to Alzheimer’s dementia; risk in treated versus untreated diabetes was lower in one study. Diabetes was also associated with increased risk of conversion from any-type or nonamnestic MCI to all-cause dementia. Metabolic syndrome and prediabetes predicted all-cause dementia in people with amnestic and any-type MCI, respectively. Mediterranean diet decreased the ris...

386 citations

Journal ArticleDOI
TL;DR: The dementia prevention potential in India, China, and this sample of Latin American countries is large, and greater than in high-income countries.

192 citations

Journal ArticleDOI
TL;DR: In this article, the authors examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up using a longitudinal study of middle and older age adults.
Abstract: Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7 h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1.22 (95% confidence interval 1.01–1.48), 1.37 (1.10–1.72), and 1.24 (0.98–1.57), respectively). Persistent short sleep duration at age 50, 60, and 70 compared to persistent normal sleep duration was also associated with a 30% increased dementia risk independently of sociodemographic, behavioural, cardiometabolic, and mental health factors. These findings suggest that short sleep duration in midlife is associated with an increased risk of late-onset dementia. Sleep dysregulation has been linked to dementia, but it is unknown whether sleep duration earlier in life is associated with dementia risk. Here, the authors show higher dementia risk associated with short sleep duration (six hours or less) in a longitudinal study of middle and older age adults.

165 citations


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01 Jan 2020
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Abstract: Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

4,408 citations

Journal ArticleDOI
TL;DR: The Lancet Commission on Dementia Prevention, Intervention, and Care met to consolidate the huge strides that have been made and the emerging knowledge as to what the authors should do to prevent and manage dementia.

3,826 citations

Journal ArticleDOI
TL;DR: Author(s): Livingston, Gill; Huntley, Jonathan; Sommerlad, Andrew ; Sommer Glad, Andrew; Ames, David; Ballard, Clive; Banerjee, Sube; Brayne, Carol; Burns, Alistair; Cohen-Mansfield, Jiska; Cooper, Claudia; Costafreda, Sergi G; Dias, Amit; Fox, Nick; Gitlin, Laura N; Howard, Robert; Kales, Helen C;

3,559 citations

Journal ArticleDOI
Emma Nichols, Cassandra Szoeke, Stein Emil Vollset, Nooshin Abbasi, Foad Abd-Allah, Jemal Abdela, Miloud Taki Eddine Aichour, Rufus Akinyemi, Fares Alahdab, Solomon Weldegebreal Asgedom, Ashish Awasthi, Suzanne Barker-Collo, Bernhard T. Baune, Yannick Béjot, Abate Bekele Belachew, Derrick A Bennett, Belete Biadgo, Ali Bijani, Muhammad Shahdaat Bin Sayeed, Carol Brayne, David O. Carpenter, Félix Carvalho, Ferrán Catalá-López, Ester Cerin, Jee-Young Jasmine Choi, Anh Kim Dang, Meaza Girma Degefa, Shirin Djalalinia, Manisha Dubey, Eyasu Ejeta Duken, David Edvardsson, Matthias Endres, Sharareh Eskandarieh, André Faro, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina Filip, Florian Fischer, Abadi Kahsu Gebre, Demeke Geremew, Maryam Ghasemi-Kasman, Elena V. Gnedovskaya, Rajeev Gupta, Vladimir Hachinski, Tekleberhan B. Hagos, Samer Hamidi, Graeme J. Hankey, Josep Maria Haro, Simon I. Hay, Seyed Sina Naghibi Irvani, Ravi Prakash Jha, Jost B. Jonas, Rizwan Kalani, André Karch, Amir Kasaeian, Yousef Khader, Ibrahim A Khalil, Ejaz Ahmad Khan, Tripti Khanna, Tawfik Ahmed Muthafer Khoja, Jagdish Khubchandani, Adnan Kisa, Katarzyna Kissimova-Skarbek, Mika Kivimäki, Ai Koyanagi, Kristopher J Krohn, Giancarlo Logroscino, Stefan Lorkowski, Marek Majdan, Reza Malekzadeh, Winfried März, João Massano, Getnet Mengistu, Atte Meretoja, Moslem Mohammadi, Maryam Mohammadi-Khanaposhtani, Ali H. Mokdad, Stefania Mondello, Ghobad Moradi, Gabriele Nagel, Mohsen Naghavi, Gurudatta Naik, Long H. Nguyen, Trang Huyen Nguyen, Yirga Legesse Nirayo, Molly R Nixon, Richard Ofori-Asenso, Felix Akpojene Ogbo, Andrew T Olagunju, Mayowa O. Owolabi, Songhomitra Panda-Jonas, Valéria Maria de Azeredo Passos, David M. Pereira, Gabriel David Pinilla-Monsalve, Michael A. Piradov, Constance D. Pond, Hossein Poustchi, Mostafa Qorbani, Amir Radfar, Robert C. Reiner, Stephen R. Robinson, Gholamreza Roshandel, Ali Rostami, Tom C. Russ, Perminder S. Sachdev, Hosein Safari, Saeid Safiri, Ramesh Sahathevan, Yahya Salimi, Maheswar Satpathy, Monika Sawhney, Mete Saylan, Sadaf G. Sepanlou, Azadeh Shafieesabet, Masood Ali Shaikh, Mohammad Ali Sahraian, Mika Shigematsu, Rahman Shiri, Ivy Shiue, João Pedro Silva, Mari Smith, Soheila Sobhani, Dan J. Stein, Rafael Tabarés-Seisdedos, Marcos Roberto Tovani-Palone, Bach Xuan Tran, Tung Thanh Tran, Amanuel Amanuel Tesfay Tsegay, Irfan Ullah, Narayanaswamy Venketasubramanian, Vasily Vlassov, Yuan-Pang Wang, Jordan Weiss, Ronny Westerman, Tissa Wijeratne, Grant M. A. Wyper, Yuichiro Yano, Ebrahim M Yimer, Naohiro Yonemoto, Mahmoud Yousefifard, Zoubida Zaidi, Zohreh Zare, Theo Vos, Valery L. Feigin, Christopher J L Murray 
TL;DR: The first detailed analysis of the global prevalence, mortality, and overall burden of dementia as captured by the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016 is presented, to highlight the most important messages for clinicians and neurologists.
Abstract: Background: The number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challe ...

1,790 citations

Journal ArticleDOI
03 Oct 2019-Cell
TL;DR: Recent advances in the understanding of AD pathobiology are reviewed and current treatment strategies are discussed, highlighting recent clinical trials and opportunities for developing future disease-modifying therapies.

1,369 citations