Showing papers by "Andrzej Rynkiewicz published in 2005"

C-344T polymorphism of the aldosterone synthase gene and blood pressure in the elderly: a population-based study.

Abstract: Objectives Whether the C-344T polymorphism of thealdosterone synthase gene is important for blood pressurecontrol remains controversial. It has been proposed that anassociationbetweenthispolymorphismandbloodpressuremight be evident in elderly subjects. The aim of the presentstudy was to test this hypothesis in an epidemiologicalcontext.Design A cross-sectional epidemiological evaluation of ahighly homogeneous unselected general population ofelderly Caucasians.Methods Lifestyle, medical history, anthropometrics,skinfold thickness, supine blood pressure, heart rate andbiochemical measures were recorded in 437 subjects aged

Clinical significance of apoptotic index in non-small cell lung cancer: correlation with p53, mdm2, pRb and p21WAF1/CIP1 protein expression

Abstract: Purpose: The aim of this study was to assess the prognostic relevance of apoptotic index (AI), considered alone or together with expression of several proteins controlling G1 check point (p53, mdm2, pRb and p21WAF1/CIP1) in non-small cell lung cancer (NSCLC) patients. Methods: Study group included 50 NSCLC patients who underwent curative pulmonary resection. Apoptosis was detected with the use of TUNEL technique and AI was defined as the number of apoptotic cells per 1,000 tumor cells. The expression of p53, mdm2, pRb and p21WAF1/CIP1 was assessed immunohistochemically. Results: The mean and median AI calculated for all 50 patients was 14 and 9, respectively. Patients with lower (<14) and higher (≥14) AI constituted 35 (70%) and 15 (30%) of cases, respectively. AI was not correlated with patient clinical characteristics, and expression of p53, pRb and p21WAF1/CIP1 . However, lower AI was correlated with over-expression of mdm2 protein (P=0.04). Median survival for patients with lower and higher AI was 43 months and 22 months, respectively, and 5-year survival probability—60 and 25%, respectively (P=0.03). In multivariate analysis, the only variable associated with shortened survival was AI (P=0.03, HR=2.9, 95% CI 1.95–3.86). Conclusions: These results suggest that AI correlates with mdm2 protein expression and influences survival in NSCLC.

Znaczenie stresu w patogenezie nadciśnienia tętniczego. Część II

Abstract: Stres jest nieuniknioną cześcią wspolczesnego zycia. Jest reakcją adaptacyjną i odpowiedzią organizmu na przezywane sytuacje. Stres odgrywa takze duzą role w rozwoju nadciśnienia tetniczego. Zostalo to udowodnione poprzez wykazanie podwyzszonej aktywności ukladu nerwowego odpowiedzialnego za reakcje na stres u ludzi z wysokim ciśnieniem tetniczym krwi. Kolejnym dowodem jest obserwowana u nich zwiekszona aktywnośc określonych struktur mozgowia odpowiedzialnych za reakcje na stres. U ludzi z wysokim ciśnieniem tetniczym krwi obserwuje sie takze zwiekszone wydzielanie hormonow związanych ze stresem.

Znaczenie stresu w patogenezie nadciśnienia tętniczego. Część I The role of the stress in the pathogenesis of hypertension. Part I

Abstract: Summary Stress is an inescapable part of the modern life. It is an adaptive response and the body’s reaction to events. Stress also plays a great role in the development of hypertension. The evidence is based on the indicators that people with high blood pressure experience an increase in overall activity of nervous system involved in response to stress. It is also known that people with hypertension have increased activity of particular structures in the brain that respond to stress. Finally, people with high blood pressure release higher amount of the stress hormones than people with normal blood pressure.