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Angela A. Waterfield
Researcher at University of Aberdeen
Publications - 20
Citations - 3742
Angela A. Waterfield is an academic researcher from University of Aberdeen. The author has contributed to research in topics: Myenteric plexus & Normorphine. The author has an hindex of 13, co-authored 20 publications receiving 3722 citations.
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Endogenous opioid peptides: multiple agonists and receptors
TL;DR: It is concluded that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.
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Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with μ and δ-receptors
TL;DR: In the alkaloid‐like series of narcotic analgesic drugs, ketobemidone, levorphanol, methadone, etorphine and the antagonist Mr 2266 had lower Nal/Leu ratios than morphine, normorphine, naloxone and naltrexone while compounds with high ratios interact mainly with μ‐receptors.
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In vitro pharmacology of the opioid peptides, enkephalins and endorphins
TL;DR: In the guinea-pig ileum methionine-enkephalin, normorphine and morphine are equipotent in depressing electrically evoked contractions but the mouse vas deferens is more sensitive to the enkephalins which are 30 to 60 times more potent than morphine.
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Assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey
TL;DR: Four benzomorphans which have potent antinociceptive activity in the hot‐plate and writhing tests in the mouse but do not suppress or precipitate withdrawal symptoms in the morphine‐dependent monkey, have been examined for their pharmacological actions in the guinea‐pig ileum and mouse vas deferens.
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Cross tolerance between morphine and methionine-enkephalin
TL;DR: Cross tolerance between morphine and methionine–enkephalin was shown to occur in the two preparations obtained from animals implanted with morphine pellets, indicating a state of tolerance in which increasing amounts of opiates will be required to maintain the desired effect.