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Angela C. Roberts
Researcher at University of Cambridge
Publications - 125
Citations - 13620
Angela C. Roberts is an academic researcher from University of Cambridge. The author has contributed to research in topics: Orbitofrontal cortex & Prefrontal cortex. The author has an hindex of 51, co-authored 116 publications receiving 12641 citations.
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Dissociation in prefrontal cortex of affective and attentional shifts
TL;DR: It is demonstrated that disinhibition, or a loss of inhibitory control, can be selective for particular cognitive functions and that different regions of the prefrontal cortex provide inhibitory Control in different aspects of cognitive processing.
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Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease
Adrian M. Owen,Angela C. Roberts,John R. Hodges,B. A. Summers,Charles E. Polkey,Trevor W. Robbins +5 more
TL;DR: The results suggest that the gross set-shifting deficits reported in both frontal lobe patients and patients with Parkinson's disease may involve fundamentally different, though related, cognitive processes, and that these may be differentially affected by medication.
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Extra-dimensional Versus Intra-Dimensional Set Shifting Performance Following Frontal Lobe Excisions, Temporal Lobe Excisions or Amygdalo-Hippocampectomy in Man
TL;DR: Both the temporal lobe patients and the amygdalo-hippocampectomy patients were unimpaired in their ability to perform either shift, although both groups had significantly prolonged selection latencies at the extra-dimensional shift stage of the task.
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Cognitive inflexibility after prefrontal serotonin depletion.
TL;DR: It is shown that upon reversal, selective serotonin depletion of the marmoset PFC produced perseverative responding to the previously rewarded stimulus without any significant effects on either retention of a discrimination learned preoperatively or acquisition of a novel discrimination postoperatively.
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Serotoninergic regulation of emotional and behavioural control processes
TL;DR: Evidence is reviewed that 5-HT modulates the impact of punishment-related signals on learning and emotion (aversion), but also promotes response inhibition, which could underlie distinct symptoms of a range of affective disorders.