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Angela Kecskés
Researcher at Katholieke Universiteit Leuven
Publications - 19
Citations - 828
Angela Kecskés is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 8 publications receiving 661 citations. Previous affiliations of Angela Kecskés include University of Pécs.
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Journal ArticleDOI
Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes.
Julian Schubert,Aleksandra Siekierska,Mélanie Langlois,Patrick May,Clément Huneau,Felicitas Becker,Hiltrud Muhle,Arvid Suls,Johannes R. Lemke,Carolien G.F. de Kovel,Holger Thiele,Kathryn Konrad,Amit Kawalia,Mohammad R. Toliat,Thomas Sander,Franz Rüschendorf,Almuth Caliebe,Inga Nagel,Bernard Kohl,Angela Kecskés,Maxime Jacmin,Katia Hardies,Sarah Weckhuysen,Erik Riesch,Thomas Dorn,Eva H. Brilstra,Stéphanie Baulac,Rikke S. Møller,Helle Hjalgrim,Bobby P. C. Koeleman,Karin Jurkat-Rott,Frank Lehman-Horn,Jared C. Roach,Gustavo Glusman,Leroy Hood,David J. Galas,Benoit Martin,Peter de Witte,Saskia Biskup,Peter De Jonghe,Ingo Helbig,Rudi Balling,Peter Nürnberg,Alexander D. Crawford,Camila V. Esguerra,Yvonne G. Weber,Holger Lerche +46 more
TL;DR: The results thus implicate STX1B and the presynaptic release machinery in fever-associated epilepsy syndromes.
Journal ArticleDOI
De Novo Loss-of-Function Mutations in CHD2 Cause a Fever-Sensitive Myoclonic Epileptic Encephalopathy Sharing Features with Dravet Syndrome
Arvid Suls,Johanna A. Jaehn,Angela Kecskés,Yvonne G. Weber,Sarah Weckhuysen,Dana Craiu,Aleksandra Siekierska,Tania Djémié,Tatiana Afrikanova,Padhraig Gormley,Sarah von Spiczak,Gerhard Kluger,Catrinel Iliescu,Tiina Talvik,Tiina Talvik,Inga Talvik,Inga Talvik,Cihan Meral,Hande Caglayan,Beatriz G. Giráldez,José M. Serratosa,Johannes R. Lemke,Dorota Hoffman-Zacharska,Elżbieta Szczepanik,Nina Barišić,Vladimir Komarek,Helle Hjalgrim,Rikke S. Møller,Tarja Linnankivi,Petia Dimova,Pasquale Striano,Federico Zara,Carla Marini,Renzo Guerrini,Christel Depienne,Christel Depienne,Stéphanie Baulac,Stéphanie Baulac,Stéphanie Baulac,Gregor Kuhlenbäumer,Alexander D. Crawford,Alexander D. Crawford,Anna-Elina Lehesjoki,Peter de Witte,Aarno Palotie,Aarno Palotie,Aarno Palotie,Holger Lerche,Camila V. Esguerra,Peter De Jonghe,Ingo Helbig,Rik Hendrickx,Philip Holmgren,Ulrich Stephani,Hiltrud Muhle,Manuela Pendiziwiat,Silke Appenzeller,Kaja Kristine Selmer,Eva H. Brilstra,Bobby P. C. Koeleman,Felix Rosenow,Eric LeGuern,Katalin Sterbova,Budisteanu Magdalena,Gherghiceanu Rodica,Oana Tarta Arsene,Barca Diana,Rosa Guerrero-López,Laura Ortega,Albena Todorova,Andrey Kirov,Angela Robbiano,Mutluay Arslan,Uluç Yiş,Vanja Ivanović +74 more
TL;DR: This study provides evidence that de novo loss-of-function mutations in CHD2 are a cause of epileptic encephalopathy with generalized seizures.
Journal Article
De novo loss-of-function mutations in chd2 cause a fever-sensitive myoclonic epileptic encephalopathy sharing features with dravet syndrome
Arvid Suls,J. J Jaehn,Angela Kecskés,Yvonne G. Weber,Sarah Weckhuysen,Dana Craiu,Aleksandra Siekierska,Tania Djémié,Tatiana Afrikanova,Padhraig Gormley,S. von Spiczak,Gerhard Kluger,Catrinel Iliescu,Tiina Talvik,Inga Talvik,C Meral,Hande Caglayan,Beatriz G. Giráldez,Jose Serratosa,Johannes R. Lemke,Dorota Hoffman-Zacharska,Elżbieta Szczepanik,Nina Barišić,Komarek,H. Hjalgrim,Rikke S. Møller,Tarja Linnankivi,Petia Dimova,Pasquale Striano,Federico Zara,Carla Marini,Renzo Guerrini,Christel Depienne,Stéphanie Baulac,G Kuhlenbaeumer,Alexander D. Crawford,A E Lehesjoki,Peter de Witte,Aarno Palotie,Holger Lerche,Camila V. Esguerra,P. De Jonghe,Ingo Helbig +42 more
Journal ArticleDOI
Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine
Yifan Zhang,Angela Kecskés,Daniëlle Copmans,Mélanie Langlois,Alexander D. Crawford,Berten Ceulemans,Lieven Lagae,Peter de Witte,Camila V. Esguerra +8 more
TL;DR: This is the first study demonstrating effective seizure inhibition of fenfluramine in an animal model of Dravet syndrome, and these results provide a basis for identifying novel analogs with improved activity and significantly milder or no side effects.
Journal ArticleDOI
Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model
Jo Sourbron,Henning Schneider,Angela Kecskés,Yusu Liu,Ellen M. Buening,Lieven Lagae,Ilse Julia Smolders,Peter de Witte +7 more
TL;DR: This study examined which 5-HT receptor subtypes can be targeted to trigger antiseizure effects in homozygous scn1Lab(-/-) mutant zebrafish larvae that recapitulate DS well and confirmed the efficacy of fenfluramine as an antiepileptiform compound in zebra fish models of DS.