A
Angela Steinmann
Researcher at Garvan Institute of Medical Research
Publications - 11
Citations - 3254
Angela Steinmann is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Pancreatic cancer & Metastasis. The author has an hindex of 6, co-authored 10 publications receiving 2488 citations. Previous affiliations of Angela Steinmann include Icahn School of Medicine at Mount Sinai.
Papers
More filters
Journal ArticleDOI
Whole genomes redefine the mutational landscape of pancreatic cancer.
Nicola Waddell,Marina Pajic,Ann-Marie Patch,David K. Chang,Karin S. Kassahn,Peter Bailey,Amber L. Johns,David Miller,Katia Nones,Kelly Quek,Michael C.J. Quinn,Alan J. Robertson,Muhammad Zaki Hidayatullah Fadlullah,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Craig Nourse,Ehsan Nourbakhsh,Shivangi Wani,Peter J. Wilson,Emma Markham,Nicole Cloonan,Matthew J. Anderson,J. Lynn Fink,Oliver Holmes,Stephen H. Kazakoff,Conrad Leonard,Felicity Newell,Barsha Poudel,Sarah Song,Darrin Taylor,Nick Waddell,Scott Wood,Qinying Xu,Jianmin Wu,Mark Pinese,Mark J. Cowley,Hong C. Lee,Marc D. Jones,Adnan Nagrial,Jeremy L. Humphris,Lorraine A. Chantrill,Venessa T. Chin,Angela Steinmann,Amanda Mawson,Emily S. Humphrey,Emily K. Colvin,Angela Chou,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,Jessica A. Pettitt,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nigel B. Jamieson,Janet Graham,Simone P. Niclou,Rolf Bjerkvig,Robert Grützmann,Daniela Aust,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Vincenzo Corbo,Claudio Bassi,Massimo Falconi,Giuseppe Zamboni,Giampaolo Tortora,Margaret A. Tempero,Anthony J. Gill,James R. Eshleman,Christian Pilarsky,Aldo Scarpa,Elizabeth A. Musgrove,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond +88 more
TL;DR: Genomic instability co-segregated with inactivation of DNA maintenance genes (BRCA1, BRCA2 or PALB2) and a mutational signature of DNA damage repair deficiency, and 4 of 5 individuals with these measures of defective DNA maintenance responded to platinum therapy.
Journal ArticleDOI
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.
Vinod P. Balachandran,Marta Łuksza,Julia N. Zhao,Vladimir Makarov,John Alec Moral,Romain Remark,Brian Herbst,Gokce Askan,Umesh Bhanot,Yasin Senbabaoglu,Daniel K. Wells,Charles Ian Ormsby Cary,Olivera Grbovic-Huezo,Marc A. Attiyeh,Benjamin D. Medina,Jennifer Q. Zhang,Jennifer K. Loo,Joseph Saglimbeni,Mohsen Abu-Akeel,Roberta Zappasodi,Nadeem Riaz,Martin Smoragiewicz,Z. Larkin Kelley,Z. Larkin Kelley,Olca Basturk,Amber L. Johns,R. Scott Mead,Anthony J. Gill,David K. Chang,David K. Chang,Skye McKay,Lorraine A. Chantrill,Venessa T. Chin,Angela Chou,Jeremy L. Humphris,Marina Pajic,Angela Steinmann,Mehreen Arshi,Mehreen Arshi,Ali Drury,Danielle Froio,Danielle Froio,Ashleigh Morgan,Paul Timpson,David Hermann,Claire Vennin,Sean C. Warren,Mark Pinese,Jianmin Wu,Andreia V. Pinho,Katherine Tucker,Lesley Andrews,Jaswinder S. Samra,Jennifer Arena,Jennifer Arena,Nick Pavlakis,Hilda High,Anubhav Mittal,Andrew V. Biankin,Peter Bailey,Sancha Martin,Elizabeth A. Musgrove,Marc D. Jones,Marc D. Jones,Craig Nourse,Nigel B. Jamieson,Alina Stoita,David Williams,Allan D. Spigelman,Nicola Waddell,John V. Pearson,Ann-Marie Patch,Katia Nones,Felicity Newell,Pamela Mukhopadhyay,Venkateswar Addala,Stephen H. Kazakoff,Oliver Holmes,Conrad Leonard,Scott Wood,Christina Xu,Sean M. Grimmond,Oliver Hofmann,Peter Wilson,Angelika N. Christ,Timothy J. C. Bruxner,Ray Asghari,Neil D. Merrett,Darren Pavey,Amitabha Das,Annabel Goodwin,Peter H. Cosman,Kasim Ismail,Chelsie O'Connor,Caroline Cooper,Peter Grimison,James G. Kench,Charbel Sandroussi,Vincent Lam,Duncan J. Mcleod,Adnan Nagrial,Judy Kirk,Virginia James,Michael Texler,Cindy Forest,Krishna Epari,Mo Ballal,David R. Fletcher,Sanjay Mukhedkar,Nikolajs Zeps,Maria Beilin,Kynan Feeney,Nan Q. Nguyen,Andrew Ruszkiewicz,Chris Worthley,John W. Chen,Mark Brooke-Smith,Virginia Papangelis,Andrew D. Clouston,P. Martin,Andrew Barbour,Thomas J. O'Rourke,Jonathan Fawcett,Kellee Slater,Michael Hatzifotis,Peter Hodgkinson,Mehrdad Nikfarjam,James R. Eshleman,Ralph H. Hruban,Christopher L. Wolfgang,Mary Hodgin,Aldo Scarpa,Rita T. Lawlor,Stefania Beghelli,Vincenzo Corbo,Maria Scardoni,Claudio Bassi,Mithat Gonen,Arnold J. Levine,Peter J. Allen,Douglas T. Fearon,Douglas T. Fearon,Miriam Merad,Sacha Gnjatic,Christine A. Iacobuzio-Donahue,Jedd D. Wolchok,Ronald P. DeMatteo,Timothy A. Chan,Benjamin Greenbaum,Taha Merghoub,Taha Merghoub,Steven D. Leach +151 more
TL;DR: In this paper, the authors used genetic, immunohistochemical and transcriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell antigens in long-term survivors of pancreatic cancer.
Journal ArticleDOI
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Claire Vennin,Claire Vennin,Venessa T. Chin,Venessa T. Chin,Sean C. Warren,Sean C. Warren,Morghan C. Lucas,Morghan C. Lucas,David Herrmann,David Herrmann,Astrid Magenau,Astrid Magenau,Pauline Mélénec,Pauline Mélénec,Stacey N. Walters,Stacey N. Walters,Gonzalo del Monte-Nieto,Gonzalo del Monte-Nieto,James R.W. Conway,James R.W. Conway,Max Nobis,Max Nobis,Amr H. Allam,Amr H. Allam,Rachael A. McCloy,Rachael A. McCloy,Nicola Currey,Nicola Currey,Mark Pinese,Mark Pinese,Alice Boulghourjian,Anaiis Zaratzian,Arne A. S. Adam,Celine Heu,Adnan Nagrial,Angela Chou,Angela Chou,Angela Chou,Angela Steinmann,Alison Drury,Danielle Froio,Marc Giry-Laterriere,Marc Giry-Laterriere,Nathanial L. E. Harris,Nathanial L. E. Harris,Tri Giang Phan,Tri Giang Phan,Rohit Jain,Wolfgang Weninger,Wolfgang Weninger,Ewan J. McGhee,Renee Whan,Amber L. Johns,Jaswinder S. Samra,Lorraine A. Chantrill,Lorraine A. Chantrill,Anthony J. Gill,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Richard P. Harvey,Richard P. Harvey,Andrew V. Biankin,Andrew V. Biankin,T.R. Jeffry Evans,Kurt I. Anderson,Shane T. Grey,Shane T. Grey,Christopher J. Ormandy,Christopher J. Ormandy,David Gallego-Ortega,David Gallego-Ortega,Yingxiao Wang,Michael S. Samuel,Owen J. Sansom,Andrew Burgess,Andrew Burgess,Thomas R. Cox,Thomas R. Cox,Jennifer P. Morton,Marina Pajic,Marina Pajic,Paul Timpson,Paul Timpson +83 more
TL;DR: A graded response to priming is demonstrated in stratified patient-derived tumors, indicating that fine-tuned tissue manipulation before chemotherapy may offer opportunities in both primary and metastatic targeting of pancreatic cancer.
Journal ArticleDOI
Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer
Angela Chou,Danielle Froio,Adnan Nagrial,Adnan Nagrial,Ashleigh Parkin,Kendelle J. Murphy,Venessa T. Chin,Dalia Wohl,Angela Steinmann,Rhys Stark,Alison Drury,Stacey N. Walters,Claire Vennin,Andrew Burgess,Andrew Burgess,Mark Pinese,Lorraine A. Chantrill,Lorraine A. Chantrill,Mark J. Cowley,Timothy J. Molloy,Nicola Waddell,Amber L. Johns,Sean M. Grimmond,David K. Chang,Andrew V. Biankin,Owen J. Sansom,Jennifer P. Morton,Shane T. Grey,Shane T. Grey,Thomas R. Cox,John Turchini,Jaswinder S. Samra,Stephen Clarke,Paul Timpson,Paul Timpson,Anthony J. Gill,Marina Pajic,Marina Pajic +37 more
TL;DR: Subtype-specific in vivo efficacy of PD-0332991-based therapy was for the first time observed at multiple stages of PDA progression: primary tumour growth, recurrence (second-line therapy) and metastatic setting and may potentially be guided by a simple biomarker (RB protein).
Journal ArticleDOI
miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense.
Marina Pajic,Marina Pajic,Danielle Froio,Sheridan Daly,Louise Doculara,Ewan K.A. Millar,Ewan K.A. Millar,Ewan K.A. Millar,Peter Graham,Alison Drury,Angela Steinmann,Charles E. de Bock,Alice Boulghourjian,Anaiis Zaratzian,Susan Carroll,Joanne Toohey,Sandra A O'Toole,Sandra A O'Toole,Sandra A O'Toole,Adrian L. Harris,Francesca M. Buffa,Harriet E. Gee,Harriet E. Gee,Georgina E Hollway,Georgina E Hollway,Timothy J. Molloy +25 more
TL;DR: It is shown that miR-139-5p is a potent modulator of radiotherapy response in breast cancer via its regulation of genes involved in multiple DNA repair and reactive oxygen species defense pathways.