Angelika Meyer

TL;DR: In vivo, inhibition of myostatin increases muscle creatine kinase activity, coincident with an increase in muscle size, demonstrating that this in vitro differentiation measure is also upregulated in vivo.

TL;DR: A GDF11-specific immunoassay is developed and a trend toward increased GDF 11 levels in sera of aged rats and humans is shown and GDF12 could be a target for pharmacologic blockade to treat age-related sarcopenia.

TL;DR: Biomarker panels for frailty would be of high value and better than single markers.

TL;DR: An unexpected connection between cytokine and Activin signaling is found, revealing a new mechanism by which cytokines affect skeletal muscle, and establishing the physiologic relevance of this pathway in the impaired regeneration seen in sarcopenia.

TL;DR: The results show that brain noradrenergic neurons express only α2A- and α2C-adrenoceptors as autoreceptors, which means the two-α2-autoreceptor hypothesis has to be replaced by a three-autorceptor hypothesis for postganglionic sympathetic neurons.