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Author

Angelika Zaszczynska

Other affiliations: Lublin University of Technology
Bio: Angelika Zaszczynska is an academic researcher from Polish Academy of Sciences. The author has contributed to research in topics: Electrospinning & Self-healing hydrogels. The author has an hindex of 5, co-authored 8 publications receiving 81 citations. Previous affiliations of Angelika Zaszczynska include Lublin University of Technology.

Papers
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Journal ArticleDOI
08 Jan 2020-Polymers
TL;DR: This paper summarizes the recent knowledge on piezoelectric materials used for tissue engineering, especially neural tissue engineering and provides a starting point for novel research pathways in the most relevant and challenging open questions.
Abstract: Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities, which still lacks an effective treatment. Tissue engineering in the post-injury brain represents a promising option for cellular replacement and rescue, providing a cell scaffold for either transplanted or resident cells. Tissue engineering relies on scaffolds for supporting cell differentiation and growth with recent emphasis on stimuli responsive scaffolds, sometimes called smart scaffolds. One of the representatives of this material group is piezoelectric scaffolds, being able to generate electrical charges under mechanical stimulation, which creates a real prospect for using such scaffolds in non-invasive therapy of neural tissue. This paper summarizes the recent knowledge on piezoelectric materials used for tissue engineering, especially neural tissue engineering. The most used materials for tissue engineering strategies are reported together with the main achievements, challenges, and future needs for research and actual therapies. This review provides thus a compilation of the most relevant results and strategies and serves as a starting point for novel research pathways in the most relevant and challenging open questions.

74 citations

Journal ArticleDOI
22 Nov 2020-Polymers
TL;DR: This paper consists of using smart materials to design medical devices and provide a greater understanding of the piezoelectric effect in the medical industry presently.
Abstract: Smart piezoelectric materials are of great interest due to their unique properties. Piezoelectric materials can transform mechanical energy into electricity and vice versa. There are mono and polycrystals (piezoceramics), polymers, and composites in the group of piezoelectric materials. Recent years show progress in the applications of piezoelectric materials in biomedical devices due to their biocompatibility and biodegradability. Medical devices such as actuators and sensors, energy harvesting devices, and active scaffolds for neural tissue engineering are continually explored. Sensors and actuators from piezoelectric materials can convert flow rate, pressure, etc., to generate energy or consume it. This paper consists of using smart materials to design medical devices and provide a greater understanding of the piezoelectric effect in the medical industry presently. A greater understanding of piezoelectricity is necessary regarding the future development and industry challenges.

58 citations

Journal ArticleDOI
TL;DR: In this paper, the authors summarized the possibility to use triaxial electrospinning to resolve the problem of limited drug solubility, to protect biomolecules from hostile environment, and to control drug release kinetics, with the possibility of loading of various drugs.
Abstract: Electrospinning is a widely investigated process for forming nanofibers Nanofibers in drug delivery systems are extensively tested due to its remarkable properties eg small pore size or large surface area Recent articles have informed about formation of fibers using triaxial electrospinning in drug delivery systems This paper summarizes the process of triaxial electrospinning and its application in drug delivery Triaxial electrospinning has advantages in forming complex nanostructures for specific drug delivery applications This paper summarizes the possibility to use triaxial electrospinning to resolve the problem of limited drug solubility, to protect biomolecules from hostile environment, and to control drug release kinetics, with the possibility of loading of various drugs There are literature data evidencing the possibility to achieve sustained release with a border case of zero rate order kinetics There is no doubt that triaxial electrospinning opens a new way to develop sophisticated nanomaterials for achieving the desired functional performances and to expand the applications in the drug delivery area Triaxial electrospinning method is interdisciplinary area with great potential in nanotechnology

49 citations

Journal ArticleDOI
TL;DR: This work demonstrates that often-overlooked electrical polarity and field strength parameters influence the dynamics of fiber electrospinning, which is crucial for designing polymer fiber properties and optimizing their collection.
Abstract: Electric field strength and polarity in electrospinning processes and their effect on process dynamics and the physical properties of as-spun fibers is studied. Using a solution of the neutral polymer such as poly(methyl methacrylate) (PMMA) we explored the electrospun jet motion issued from a Taylor cone. We focused on the straight jet section up to the incipient stage of the bending instability and on the radius of the disk of the fibers deposited on the collecting electrode. A new correlation formula using dimensionless parameters was found, characterizing the effect of the electric field on the length of the straight jet, L˜E~E˜0.55. This correlation was found to be valid when the spinneret was either negatively or positively charged and the electrode grounded. The fiber deposition radius was found to be independent of the electric field strength and polarity. When the spinneret was negatively charged, L˜E was longer, the as-spun fibers were wider. The positively charged setup resulted in fibers with enhanced mechanical properties and higher crystallinity. This work demonstrates that often-overlooked electrical polarity and field strength parameters influence the dynamics of fiber electrospinning, which is crucial for designing polymer fiber properties and optimizing their collection.

29 citations

Journal ArticleDOI
TL;DR: The state-of-the-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements is summarized in this article, where the following topics are discussed: systematics of the available 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.
Abstract: Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.

27 citations


Cited by
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Journal ArticleDOI
TL;DR: A comprehensive review on the state-of-the-art of piezoelectric energy harvesting is presented in this paper, where the authors present the broad spectrum of applications of piezolectric materials for clean power supply to wireless electronics in diverse fields.

418 citations

Journal ArticleDOI
TL;DR: In this paper, the design rationale of electroactive biomaterials is discussed for imitating dynamic cell microenvironment, as well as their mediated electrostimulation and the applying pathways.
Abstract: During natural tissue regeneration, tissue microenvironment and stem cell niche including cell-cell interaction, soluble factors, and extracellular matrix (ECM) provide a train of biochemical and biophysical cues for modulation of cell behaviors and tissue functions. Design of functional biomaterials to mimic the tissue/cell microenvironment have great potentials for tissue regeneration applications. Recently, electroactive biomaterials have drawn increasing attentions not only as scaffolds for cell adhesion and structural support, but also as modulators to regulate cell/tissue behaviors and function, especially for electrically excitable cells and tissues. More importantly, electrostimulation can further modulate a myriad of biological processes, from cell cycle, migration, proliferation and differentiation to neural conduction, muscle contraction, embryogenesis, and tissue regeneration. In this review, endogenous bioelectricity and piezoelectricity are introduced. Then, design rationale of electroactive biomaterials is discussed for imitating dynamic cell microenvironment, as well as their mediated electrostimulation and the applying pathways. Recent advances in electroactive biomaterials are systematically overviewed for modulation of stem cell fate and tissue regeneration, mainly including nerve regeneration, bone tissue engineering, and cardiac tissue engineering. Finally, the significance for simulating the native tissue microenvironment is emphasized and the open challenges and future perspectives of electroactive biomaterials are concluded.

86 citations

Journal ArticleDOI
TL;DR: A detailed review of electrospun gelatin-based nanofiber dressing materials without or with therapeutic agents for wound healing and skin regeneration applications is provided in this paper , where various crosslinking approaches including physical, chemical, and biological methods have been introduced.
Abstract: Electrospun nanofiber materials have been considered as advanced dressing candidates in the perspective of wound healing and skin regeneration, originated from their high porosity and permeability to air and moisture, effective barrier performance of external pathogens, and fantastic extracellular matrix (ECM) fibril mimicking property. Gelatin is one of the most important natural biomaterials for the design and construction of electrospun nanofiber-based dressings, due to its excellent biocompatibility and biodegradability, and great exudate-absorbing capacity. Various crosslinking approaches including physical, chemical, and biological methods have been introduced to improve the mechanical stability of electrospun gelatin-based nanofiber mats. Some innovative electrospinning strategies, including blend electrospinning, emulsion electrospinning, and coaxial electrospinning, have been explored to improve the mechanical, physicochemical, and biological properties of gelatin-based nanofiber mats. Moreover, numerous bioactive components and therapeutic agents have been utilized to impart the electrospun gelatin-based nanofiber dressing materials with multiple functions, such as antimicrobial, anti-inflammation, antioxidation, hemostatic, and vascularization, as well as other healing-promoting capacities. Noticeably, electrospun gelatin-based nanofiber mats integrated with specific functions have been fabricated to treat some hard-healing wound types containing burn and diabetic wounds. This work provides a detailed review of electrospun gelatin-based nanofiber dressing materials without or with therapeutic agents for wound healing and skin regeneration applications.

85 citations

Journal ArticleDOI
24 Jun 2020
TL;DR: In this paper, the authors used electromagnetic shielding materials generated with the extensive application of electromagnetic wave have been utilized in military radar stealth, electromagnetic shielding of advanced electronic electronic devices have been used in the field of radar stealth.
Abstract: Electromagnetic shielding materials generated with the extensive application of electromagnetic wave have been utilized in military radar stealth, electromagnetic shielding of advanced electronic e...

72 citations