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Angelo C. Pinto

Bio: Angelo C. Pinto is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Isatin & Diterpene. The author has an hindex of 39, co-authored 307 publications receiving 6744 citations. Previous affiliations of Angelo C. Pinto include Oswaldo Cruz Foundation & University of Graz.
Topics: Isatin, Diterpene, Copaiba Oil, Copaiba, Copaifera


Papers
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TL;DR: The chemical composition and pharmacological properties of the very efficient medicinal plant Croton cajucara were investigated according to ethnopharmacological approaches and proved to be both efficient and successful.
Abstract: This paper presents a program emphasizing ethnopharmacological approaches that could allow great success in the study of medicinal plants. The minimum ethnopharmacological research team should consist of a botanist, a chemist and a pharmacologist with each carrying the responsibility for answering in sequential fashion critical questions. The chemical composition and pharmacological properties of the very efficient medicinal plant Croton cajucara were investigated according to ethnopharmacological approaches. The study with this Croton proved to be both efficient and successful. This happy situation was only possible because a multidisciplinary team was involved getting the research done correctly. The ethnopharmacological study involving one other especies Copaifera will be cited.

560 citations

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TL;DR: The use of copaiba and sacaca plants as well as their adulteration and side effects, and the new regulations on phytotherapeutic registration in Brazil and Europe are discussed.
Abstract: This paper reviews the recent literature on synergism, adulteration and risks of using medicinal plants. The use of copaiba and sacaca plants as well as their adulteration and side effects, are also described. In addition, the new regulations on phytotherapeutic registration in Brazil and Europe are discussed.

502 citations

Journal ArticleDOI
TL;DR: This review details the history, chemistry and pharmacology of the Copaifera L. genus (Leguminosae - Caesalpinoideae), including copaiba oils.
Abstract: This review details the history, chemistry and pharmacology of the Copaifera L. genus (Leguminosae - Caesalpinoideae), including copaiba oils.

250 citations

Journal ArticleDOI
TL;DR: Derivatives of isoniazid (INH), (E)-N'-[(1-aryl)-1H-1,2,3-triazole-4-yl)methylene] isonicotinoyl hydrazides, exhibited significant activity and displayed low cytotoxicity against liver cells and kidney cells, thereby providing a high therapeutic index.
Abstract: The purpose of this study was to prepare various 4-substituted N-phenyl-1,2,3-triazole derivatives using click chemistry. The derivatives were screened in vitro for antimicrobial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294) using the Alamar Blue susceptibility test. The activity was expressed as the minimum inhibitory concentration (MIC) in μg/mL (μM). Derivatives of isoniazid (INH), (E)-N'-[(1-aryl)-1H-1,2,3-triazole-4-yl)methylene] isonicotinoyl hydrazides, exhibited significant activity with MIC values ranging from 2.5 to 0.62 μg/mL. In addition, they displayed low cytotoxicity against liver cells (hepatoma HepG2) and kidney cells (BGM), thereby providing a high therapeutic index. The results demonstrated the potential and importance of developing new INH derivatives to treat mycobacterial infections.

233 citations

Journal ArticleDOI
TL;DR: The Copaiba Oil from Copaifera multijuga Hayne (100 mg/kg) was the most potent, inhibiting both NO production and the pleurisy induced by zymosan, and the oleoresins from CopAifera cearensis Huber ex Ducke and Copaifiera reticulata Ducke were also able to inhibit NOProduction and the Pleurisy but with less intensity.

222 citations


Cited by
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Journal ArticleDOI
10 Mar 1970

8,159 citations

Journal ArticleDOI
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.

4,649 citations

Journal ArticleDOI
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
Abstract: The biaryl structural motif is a predominant feature in many pharmaceutically relevant and biologically active compounds. As a result, for over a century 1 organic chemists have sought to develop new and more efficient aryl -aryl bond-forming methods. Although there exist a variety of routes for the construction of aryl -aryl bonds, arguably the most common method is through the use of transition-metalmediated reactions. 2-4 While earlier reports focused on the use of stoichiometric quantities of a transition metal to carry out the desired transformation, modern methods of transitionmetal-catalyzed aryl -aryl coupling have focused on the development of high-yielding reactions achieved with excellent selectivity and high functional group tolerance under mild reaction conditions. Typically, these reactions involve either the coupling of an aryl halide or pseudohalide with an organometallic reagent (Scheme 1), or the homocoupling of two aryl halides or two organometallic reagents. Although a number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps. In particular, the obligation to use coupling partners that are both activated is wasteful since it necessitates the installation and then subsequent disposal of stoichiometric activating agents. Furthermore, preparation of preactivated aryl substrates often requires several steps, which in itself can be a time-consuming and economically inefficient process.

3,204 citations