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Angus I. Lamond
Researcher at University of Dundee
Publications - 335
Citations - 33401
Angus I. Lamond is an academic researcher from University of Dundee. The author has contributed to research in topics: RNA splicing & snRNP. The author has an hindex of 95, co-authored 323 publications receiving 30920 citations. Previous affiliations of Angus I. Lamond include National Institute for Medical Research & University of Glasgow.
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The multifunctional nucleolus
TL;DR: Although the nucleolus is primarily associated with ribosome biogenesis, several lines of evidence now show that it has additional functions, such as regulation of mitosis, cell-cycle progression and proliferation, many forms of stress response and biogenesis of multiple ribonucleoprotein particles.
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Nucleolar proteome dynamics
Jens S. Andersen,Yun Wah Lam,Anthony K.L. Leung,Shao En Ong,Carol E. Lyon,Angus I. Lamond,Matthias Mann +6 more
TL;DR: The data establish a quantitative proteomic approach for the temporal characterization of protein flux through cellular organelles and demonstrate that the nucleolar proteome changes significantly over time in response to changes in cellular growth conditions.
Journal ArticleDOI
Directed proteomic analysis of the human nucleolus.
Jens S. Andersen,Carol E. Lyon,Archa H. Fox,Anthony K.L. Leung,Yun Wah Lam,Hanno Steen,Matthias Mann,Angus I. Lamond +7 more
TL;DR: This extensive proteomic analysis of human nucleoli shows that nucleoli have a surprisingly large protein complexity and supports the view that the nucleolus may perform additional functions beyond its known role in ribosome subunit biogenesis.
Journal ArticleDOI
Nuclear speckles: a model for nuclear organelles.
Angus I. Lamond,David L. Spector +1 more
TL;DR: Speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors and are located in the interchromatin regions of the nucleoplasm of mammalian cells, and can cycle continuously between speckles and other nuclear locations, including active transcription sites.
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Structure and Function in the Nucleus
TL;DR: This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.