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Ani Hakobyan

Other affiliations: Yerevan State University
Bio: Ani Hakobyan is an academic researcher from University of Rostock. The author has contributed to research in topics: Trifluoroacetic anhydride & Thioglycolates. The author has an hindex of 4, co-authored 6 publications receiving 93 citations. Previous affiliations of Ani Hakobyan include Yerevan State University.

Papers
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Journal ArticleDOI
TL;DR: In this article, the starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride.

38 citations

Journal ArticleDOI
TL;DR: The photophysical properties of selected compounds were investigated and compared to each other, and very good fluorescence quantum yields were observed, especially for the pyridine derivatives.
Abstract: Tetra(arylalkynyl)pyridines and tetra(arylalkenyl)pyridines and their benzene analogues were prepared by palladium-catalyzed cross-coupling reactions from the commercially available chlorinated substrates in good to excellent yields. The photophysical properties of selected compounds were investigated and compared to each other. Very good fluorescence quantum yields were observed, especially for the pyridine derivatives.

28 citations

Journal ArticleDOI
TL;DR: The first synthesis of 3-dichloroacetylchromone from 3-dimethylamino-1-(2-hydroxyphenyl)propen-1-one and dichlo- roacetyl chloride is described in this paper.
Abstract: The first synthesis of 3-(dichloroacetyl)chromone from 3-(dimethylamino)-1-(2-hydroxyphenyl)propen-1-one and dichlo- roacetyl chloride is described. The reaction of electron-rich amino- heterocycles with 3-(dichloroacetyl)chromone provides a set of diverse fused pyridines bearing the CHCl2-substituent at the a-posi- tion of the pyridine core. Subsequent hydrolysis leads to the forma- tion of annulated a-(formyl)pyridines.

23 citations

Journal ArticleDOI
TL;DR: In this paper, the synthesis of 1-deazapurines and isosteres bearing the exocyclic nitrogen atom at position-1 was developed based on the formal [3+3]-cyclization reaction of nitro-malonaldehyde with the set of electron-excessive aminoheterocycles.

14 citations

Journal ArticleDOI
TL;DR: In this article, the starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride.
Abstract: 4-Chloro-3-(trifluoroacetyl)- and 4-chloro-3-(methoxalyl)coumarins react with electron-rich aminoheterocycles, dimethyl 1,3-acetonedicarboxylate, hydrazines, alkyl thioglycolates, and methyl sarcosinate to give a variety of 3,4-heteroannulated coumarins. The starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride. An NMR study and X-ray crystallographic analysis are reported.

2 citations


Cited by
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Journal ArticleDOI
TL;DR: In this article, the starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride.

38 citations

Journal ArticleDOI
TL;DR: An efficient and practical route to 7-azaindole framework has been developed by one-pot, three-component cyclocondensation of N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds in ethanol or acetic acid at reflux.
Abstract: An efficient and practical route to 7-azaindole framework has been developed by one-pot, three-component cyclocondensation of N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds in ethanol or acetic acid at reflux. Reactions involving tetronic acid, indane-1,3-dione, dimedone, and 5-phenylcyclohexane-1,3-dione gave carbocyclic fused 7-azaindoles, whereas Meldrum’s acid, benzoylacetonitrile, and malononitrile resulted in the highly substituted 7-azaindole derivatives, making this strategy very useful in diversity-oriented synthesis (DOS).

36 citations

Journal ArticleDOI
TL;DR: In this paper, a series of novel 1,2-isoxazole-pyridobenzimidazole is synthesized, which are supported by 1H and 13C NMR, and mass spectra.
Abstract: A series of novel 1,2-isoxazole-pyridobenzimidazole is synthesized. Structures of the products are supported by 1H and 13C NMR, and mass spectra. All compounds have been tested for their anticancer activity towards four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colon-205 (colon cancer), and A2780 (ovarian cancer). Etoposide was used as a standard drug. The determined IC50 values range from 0.01±0.003 to 23.7±3.72 µM. Among all compounds, six products exhibit the most significant activities.

34 citations

Journal ArticleDOI
TL;DR: Low toxicity of compounds 33d and 33e was observed against human umbilical vein endothelial cells (HUVECs), suggesting their acceptable safety profiles in normal cells.

33 citations