Anisha Luthra

TL;DR: An experimental demonstration that multiplexing of guide RNAs can both significantly increase the drive conversion efficiency and reduce germline resistance rates of a CRISPR homing gene drive in Drosophila melanogaster and shows that an autosomal drive can achieve drive conversion in the male germline, with no subsequent formation of resistance alleles in embryos through paternal carryover of Cas9.

TL;DR: The MSK-MET dataset as discussed by the authors is an integrated pan-cancer cohort of tumor genomic and clinical outcome data from more than 25,000 patients to identify associations between tumor genomic alterations and patterns of metastatic dissemination across 50 tumor types.

TL;DR: To investigate the effects of natural genetic variation on resistance formation in Drosophila melanogaster, a CRISPR homing gene drive was developed and crossed into the genetically diverse DGRP lines, measuring several performance parameters and finding resistance and conversion rates were not explained by common alleles of large effect.

TL;DR: A flexible maximum likelihood framework is developed that can disentangle different components of fitness from genotype frequency data, and estimate them individually in males and females and should be generally applicable to situations where it is important to quantify fitness components of specific genetic variants.

TL;DR: In this article , the authors analyzed genomic and transcriptomic profiles of 738 untreated rectal cancers and identified biomarkers of response that could inform patient selection for non-operative treatment strategies.