Anjali Geethadevi

TL;DR: This results demonstrate that miR551b-3p translocates to the nucleus with the aid of importin-8 (IPO8) and activates STAT3 transcription, and upregulates the expression of oncostatin M receptor (OSMR) and interleukin-31 receptor-α (IL-31RA) as well as their ligands OSM and IL-31 throughSTAT3 transcription.

TL;DR: Findings indicate that the invading TNBC cells interact with astrocytes in the brain microenvironment that facilitates brain metastases of T NBC cells through a TGF-β2/ANGPTL4 axis.

TL;DR: It is shown that furin activates the IGF1R/STAT3 signaling axis in ovarian cancer cells and reduced tumor cell migration and invasion in vitro and tumor growth and metastasis in vivo.

TL;DR: Results obtained from HPLC analysis showed that the betaine accumulation suppresses the de-novo synthesis of ectoine partially at low NaCl concentration in the growth medium, however, at a highNaCl concentration, the ectoine concentration increases abruptly as compared to the bet Kaine, indicating that the ectPierre accumulation is transcriptionally up-regulated by the salinity stress.

TL;DR: Results demonstrate that FOXM1 and EGFR/ERBB2 pathways are key points of vulnerability for therapy to disrupt peritoneal spread and adhesion of ovarian cancer cells.