Showing papers by "Anju Chadha published in 1991"
128 citations
TL;DR: Although the solution chemistry of diol epoxides is now fairly well understood, a great deal remains to be elucidated regarding their reaction in the presence of DNA, and detailed conformational analysis of adducted DNA should prove to be extremely valuable in developing mechanistic models for the enzymatic processing of chemically altered DNA.
Abstract: Fifteen years ago, we proposed bay-region diol epoxides as the reactive metabolites responsible for the tumorigenic activity of polycyclic aromatic hydrocarbons (Jerina and Daly, 1976; Jerina et al, 1976; Jerina and Lehr, 1977) In the intervening period, extensive studies from several laboratories have provided substantial evidence that over a dozen hydrocarbons are activated by this pathway (Jerina et al, 1984; Lehr et al, 1985; Thakker et al, 1985) Examples have been forthcoming from a variety of structural types including benz- and dibenzanthracenes and acridines, benz- and dibenzpyrenes, chrysenes, and benzo[c]phenanthrene To date, there are no known examples of carcinogenic alternant polycyclic aromatic hydrocarbons for which a bay-region diol epoxide is not an ultimate carcinogen Although a number of mechanistically attractive alternatives to bay-region diol epoxides exist (Watabe et al, 1989; Cavalieri and Rogan, 1985; Miller et al, this volume), the extent of their contribution to the overall carcinogenicity of the hydrocarbons remains to be established
91 citations