Author
Anna-Britta Hörnfeldt
Bio: Anna-Britta Hörnfeldt is an academic researcher from Lund University. The author has contributed to research in topics: Thiophene & Pyridine. The author has an hindex of 20, co-authored 138 publications receiving 1668 citations.
Topics: Thiophene, Pyridine, Alkylation, Coupling reaction, Tautomer
Papers published on a yearly basis
Papers
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TL;DR: In this article, the Suzuki Pd(0)-catalyzed coupling between arylboronic acids and bromides or iodides in weakly alkaline medium was evaluated.
122 citations
TL;DR: It has been found that the addition of cupric oxide to the crosscoupling reaction (Stille reaction) of 2-tributylstannylpyridine with various halobenzenes and heterocyclic halides leads to a much faster reaction and higher yields as mentioned in this paper.
89 citations
TL;DR: The Pd-catalyzed coupling of heteroaryl trialkylstannanes with a variety of heterosalt halides has been shown to be greatly promoted by silver(I)oxide as mentioned in this paper.
53 citations
43 citations
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3,281 citations
950 citations
872 citations
TL;DR: This research presents a new generation of state-of-the-art materials for bioorganic and non-volatile organometallic research that combines high-performance liquid chromatography and high-tech materials for organic synthesis.
Abstract: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, 202 Chengfu Road, 098#, Beijing 100871, China State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 200060, China
830 citations
Patent•
24 Nov 1992
TL;DR: In this article, novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases, which can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence.
Abstract: Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used as pharmaceutical agents to treat various diseases such as those caused by viruses and can be used for diagnostic purposes in order to detect viruses or disease conditions.
753 citations