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Anna H. Bramley
Researcher at Cornell University
Publications - 3
Citations - 2947
Anna H. Bramley is an academic researcher from Cornell University. The author has contributed to research in topics: Progenitor cell & Bone marrow. The author has an hindex of 3, co-authored 3 publications receiving 2696 citations.
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Journal ArticleDOI
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden +20 more
TL;DR: A requirement for VEGFR1+ haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) home to tumour-specific pre-metastatic sites and form cellular clusters before the arrival of tumour cells is demonstrated.
Journal ArticleDOI
p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.
Anxo Vidal,Anxo Vidal,Stergios Zacharoulis,Stergios Zacharoulis,Wenjun Guo,David R. Shaffer,Filippo G Giancotti,Anna H. Bramley,Carmen de la Hoz,Kristian Jensen,Daniel Kato,Daniel D. MacDonald,Joseph Knowles,Nancy Yeh,Lawrence A. Frohman,Shahin Rafii,David Lyden,Andrew Koff +17 more
TL;DR: It is reported that mice lacking the cell cycle inhibitors p130 and p27 show defects in tumor neoangiogenesis, both in xenografts and spontaneously arising tumors, and it is suggested that cell expansion and mobilization from the bone marrow of angiogenic precursors are separable events.
Journal ArticleDOI
Kaplan et al. reply
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden,Jared Wels +21 more
TL;DR: It is shown that VEGFR1 knockdown in myelomonocytic cells eradicates micro- and macrometastases in a non-amputation/resection tumour model.