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Anna-Lotta Kaivorinne
Researcher at Oulu University Hospital
Publications - 7
Citations - 3970
Anna-Lotta Kaivorinne is an academic researcher from Oulu University Hospital. The author has contributed to research in topics: Frontotemporal lobar degeneration & Trinucleotide repeat expansion. The author has an hindex of 7, co-authored 7 publications receiving 3471 citations. Previous affiliations of Anna-Lotta Kaivorinne include National Institutes of Health & University of Oulu.
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Journal ArticleDOI
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
Alan E. Renton,Elisa Majounie,Adrian James Waite,Javier Simón-Sánchez,Javier Simón-Sánchez,Sara Rollinson,J. Raphael Gibbs,J. Raphael Gibbs,Jennifer C. Schymick,Hannu Laaksovirta,John C. van Swieten,John C. van Swieten,Liisa Myllykangas,Hannu Kalimo,Anders Paetau,Yevgeniya Abramzon,Anne M. Remes,Alice Kaganovich,Sonja W. Scholz,Sonja W. Scholz,Sonja W. Scholz,Jamie Duckworth,Jinhui Ding,Daniel W. Harmer,Dena G. Hernandez,Dena G. Hernandez,Janel O. Johnson,Janel O. Johnson,Kin Y. Mok,Mina Ryten,Danyah Trabzuni,Rita Guerreiro,Richard W. Orrell,James Neal,Alexandra Murray,J. P. Pearson,Iris E. Jansen,David Sondervan,Harro Seelaar,Derek J. Blake,Kate Young,Nicola Halliwell,Janis Bennion Callister,Greg Toulson,Anna Richardson,Alexander Gerhard,Julie S. Snowden,David M. A. Mann,David Neary,Mike A. Nalls,Terhi Peuralinna,Lilja Jansson,Veli-Matti Isoviita,Anna-Lotta Kaivorinne,Maarit Hölttä-Vuori,Elina Ikonen,Raimo Sulkava,Michael Benatar,Joanne Wuu,Adriano Chiò,Gabriella Restagno,Giuseppe Borghero,Mario Sabatelli,David Heckerman,Ekaterina Rogaeva,Lorne Zinman,Jeffrey D. Rothstein,Michael Sendtner,Carsten Drepper,Evan E. Eichler,Can Alkan,Ziedulla Abdullaev,Svetlana Pack,Amalia Dutra,Evgenia Pak,John Hardy,Andrew B. Singleton,Nigel Williams,Peter Heutink,Stuart Pickering-Brown,Huw R. Morris,Huw R. Morris,Huw R. Morris,Pentti J. Tienari,Bryan J. Traynor,Bryan J. Traynor +85 more
TL;DR: The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases, and a large hexanucleotide repeat expansion in the first intron of C9ORF72 is shown.
Journal ArticleDOI
Role of MAPT mutations and haplotype in frontotemporal lobar degeneration in Northern Finland
Anna-Lotta Kaivorinne,Anna-Lotta Kaivorinne,Johanna Krüger,Johanna Krüger,Katja Kuivaniemi,Hannu Tuominen,Virpi Moilanen,Kari Majamaa,Kari Majamaa,Kari Majamaa,Anne M. Remes,Anne M. Remes +11 more
TL;DR: It is concluded that although pathogenic MAPT mutations are rare in Northern Finland, the MAPT H2 allele may be associated with increased risks of FTLD and eoAD in the Finnish population.
Journal ArticleDOI
Slowly progressive frontotemporal lobar degeneration caused by the C9ORF72 repeat expansion: a 20-year follow-up study.
Noora-Maria Suhonen,Anna-Lotta Kaivorinne,Virpi Moilanen,Michaela K. Bode,R. Takalo,Tuomo Hänninen,Anne M. Remes +6 more
TL;DR: It is indicated that there is great individual variation in the progression and duration of C9ORF72-associated FTLD, and also language variants or mixed phenotypes may be present.
Journal ArticleDOI
Clinical Characteristics of C9ORF72-Linked Frontotemporal Lobar Degeneration.
Anna-Lotta Kaivorinne,Michaela K. Bode,Liisa Paavola,Hannu Tuominen,Mika Kallio,Alan E. Renton,Bryan J. Traynor,Virpi Moilanen,Anne M. Remes +8 more
TL;DR: A high frequency of neuropsychiatric symptoms is detected; however, these symptoms seem not to be specific to C9ORF72-associated FTLD, which should be considered in cases of middle-age-onset psychosis.
Journal ArticleDOI
Low prevalence of progranulin mutations in Finnish patients with frontotemporal lobar degeneration
Johanna Krüger,Anna-Lotta Kaivorinne,Anna-Lotta Kaivorinne,Bjarne Udd,Kari Majamaa,Kari Majamaa,Kari Majamaa,Anne M. Remes,Anne M. Remes +8 more
TL;DR: The aim of this study was to determine mutations and genetic variations of the PGRN gene in Finnish patients with FTLD and FTLD with associated motor neuron disease (FTLD‐MND).