A
Anna M. Dowbaj
Researcher at Max Planck Society
Publications - 2
Citations - 28
Anna M. Dowbaj is an academic researcher from Max Planck Society. The author has contributed to research in topics: Notch signaling pathway & Stromal cell. The author has an hindex of 1, co-authored 2 publications receiving 2 citations.
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Journal ArticleDOI
Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.
Lucía Cordero-Espinoza,Lucía Cordero-Espinoza,Lucía Cordero-Espinoza,Anna M. Dowbaj,Timo N Kohler,Timo N Kohler,Bernhard Strauss,Olga Sarlidou,German Belenguer,Clare Pacini,Nuno P. Martins,Ross Dobie,John R. Wilson-Kanamori,Richard Butler,Nicole Prior,Palle Serup,Florian Jug,Neil C. Henderson,Florian Hollfelder,Meritxell Huch +19 more
TL;DR: In this article, using organoid co-cultures that recapitulate the ductal-to-mesenchymal cell architecture of the portal tract, the authors demonstrate that a subpopulation of mouse periportal mesenchymythropoietin cells exerts dual control on proliferation of the epithelium.
Posted ContentDOI
The proportion of periportal mesenchyme to ductal epithelial cells acts as a proliferative rheostat in liver regeneration
Lucía Cordero-Espinoza,Timo N Kohler,Anna M. Dowbaj,Bernhard Strauss,Olga Sarlidou,Clare Pacini,Ross Dobie,John R. Wilson-Kanamori,Richard Butler,Palle Serup,Neil C. Henderson,Florian Hollfelder,Meritxell Huch +12 more
TL;DR: A subpopulation of SCA1+ periportal mesenchymal cells that closely surrounds ductal cells in vivo and exerts a dual control on their proliferative capacity is described, which re-evaluate the concept of the cellular niche.