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Annalisa Nicotra
Researcher at University of Palermo
Publications - 8
Citations - 190
Annalisa Nicotra is an academic researcher from University of Palermo. The author has contributed to research in topics: Stem cell & Colorectal cancer. The author has an hindex of 4, co-authored 8 publications receiving 64 citations. Previous affiliations of Annalisa Nicotra include University of Bologna.
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Journal ArticleDOI
PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells
Laura Rosa Mangiapane,Annalisa Nicotra,Alice Turdo,Miriam Gaggianesi,Paola Bianca,Simone Di Franco,Davide Stefano Sardina,Veronica Veschi,Michele Signore,Sven Beyes,Luca Fagnocchi,Micol E. Fiori,Maria Rita Bongiorno,Melania Lo Iacono,Irene Pillitteri,Gloria Ganduscio,Gaspare Gulotta,Jan Paul Medema,Alessio Zippo,Matilde Todaro,Ruggero De Maria,Giorgio Stassi +21 more
TL;DR: In this paper, the authors defined the expression of HER2 in colorectal cancer stem cells (CSCs) and its possible role as therapeutic target in CRC resistant to anti-epidermal growth factor receptor (EGFR) therapy.
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Combined platelet-rich plasma and lipofilling treatment provides great improvement in facial skin-induced lesion regeneration for scleroderma patients
Francesco Virzì,Paola Bianca,Alessandro Giammona,Tiziana Apuzzo,Simone Di Franco,Laura Rosa Mangiapane,Maria Luisa Colorito,Dario Catalano,Emanuela Scavo,Annalisa Nicotra,Antonina Benfante,Giuseppe Pistone,Valentina Caputo,Francesco Dieli,Roberto Pirrello,Giorgio Stassi +15 more
TL;DR: Histopathological and phenotypical analysis of adipose tissue from SSc patients revealed a disorganization of its distinct architecture coupled with an altered cell composition, which could be exploited for the treatment of chronic connective tissue diseases, including SSc.
Journal ArticleDOI
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Simone Di Franco,Paola Bianca,Davide Stefano Sardina,Alice Turdo,Miriam Gaggianesi,Veronica Veschi,Annalisa Nicotra,Laura Rosa Mangiapane,Melania Lo Iacono,Irene Pillitteri,Sander R. van Hooff,Federica Martorana,Gianmarco Motta,Eliana Gulotta,Vincenzo Luca Lentini,Emanuele Martorana,Micol E. Fiori,Salvatore Vieni,Maria Rita Bongiorno,Giorgio Giannone,Dario Giuffrida,Lorenzo Memeo,Lorenzo Colarossi,Marzia Mare,Paolo Vigneri,Matilde Todaro,Ruggero De Maria,Jan Paul Medema,Giorgio Stassi +28 more
TL;DR: In this article, the authors show that visceral adipose derived factors promote vasculogenesis and metastatic dissemination by activation of STAT3, which inhibits miR-200a and enhances ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.
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CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin.
Simone Di Franco,Barbara Parrino,Miriam Gaggianesi,Vincenzo Davide Pantina,Paola Bianca,Annalisa Nicotra,Laura Rosa Mangiapane,Melania Lo Iacono,Gloria Ganduscio,Veronica Veschi,Ornella Roberta Brancato,Antonino Glaviano,Alice Turdo,Irene Pillitteri,Lorenzo Colarossi,Stella Cascioferro,Daniela Carbone,Camilla Pecoraro,Micol E. Fiori,Ruggero De Maria,Matilde Todaro,Isabella Screpanti,Girolamo Cirrincione,Patrizia Diana,Giorgio Stassi +24 more
TL;DR: In this paper, the authors reported that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, nortopsentin 234 (NORA234), leads to an initial reduction of proliferative and clonogenic potential of CRC sphere cells, followed by an adaptive response selecting the CR-CSphC-resistant compartment.
Journal ArticleDOI
Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant.
Veronica Veschi,Laura Rosa Mangiapane,Annalisa Nicotra,Simone Di Franco,Emanuela Scavo,Tiziana Apuzzo,Davide Stefano Sardina,Micol E. Fiori,Antonina Benfante,Maria Luisa Colorito,Gianfranco Cocorullo,Felice Giuliante,Calogero Cipolla,Giuseppe Pistone,Maria Rita Bongiorno,Aroldo Rizzo,Courtney M. Tate,Xiaohua Wu,Scott William Rowlinson,Louis Stancato,Matilde Todaro,Ruggero De Maria,Giorgio Stassi +22 more
TL;DR: Data suggest that BMP7v treatment may represent a useful antiangiogenic and prodifferentiation agent, which renders CSCs sensitive to both standard and targeted therapies.