Author
Annamalai Senthilmurugan
Bio: Annamalai Senthilmurugan is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Julia olefination & Excited state. The author has an hindex of 3, co-authored 6 publications receiving 50 citations.
Topics: Julia olefination, Excited state, Phenylene, Stimulated emission, Laser
Papers
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TL;DR: In this paper, the synthesis of (+)-varitriol analogues was achieved through the use of Julia olefination and the potential anticancer properties of 1 coupled with their interest in developing building blocks that enable olefin formation under the Julia protocol constitute the basis of their research project.
37 citations
TL;DR: In this paper, two bifunctional building blocks that enable a C-C bond formation through a Julia-Kocienski reaction were synthesized and the orthogonal nature of the two functional groups in these building blocks allowed the sequential olefination of commercially available aromatic aldehydes and the intermediate stilbene aldehyde to deliver an efficient and new route for bis(styrylbenzenes) with Weinreb amide (WA) functionality for the first time.
8 citations
TL;DR: This is the first report for the synthesis of 1,4-phenylene spaced sugars via C-C bond formation and a building block combining the usefulness of Weinreb amide functionality and modified Julia olefination reaction has been explored towards this objective.
5 citations
TL;DR: A newly synthesized donor-acceptor molecule (E )-methyl 2-(4-(dimethylamino)styryl)benzoate ( trans -MDMASB) has been investigated in various non-polar and polar solvents as mentioned in this paper.
3 citations
TL;DR: In this paper, two bifunctional building blocks that enable a C-C bond formation through a Julia-Kocienski reaction were synthesized and the orthogonal nature of the two functional groups in these building blocks allowed the sequential olefination of commercially available aromatic aldehydes and the intermediate stilbene aldehyde to deliver an efficient and new route for bis(styrylbenzenes) with Weinreb amide (WA) functionality for the first time.
Abstract: In an effort to arrive at bis(styrylbenzene) derivatives, which are known for their importance in connection to Alzheimer's disease, two bifunctional building blocks that enable a C–C bond formation through a Julia–Kocienski reaction were synthesized. The orthogonal nature of the two functional groups in these building blocks allow the sequential olefination of commercially available aromatic aldehydes and the intermediate stilbene aldehydes to deliver an efficient and new route for bis(styrylbenzenes) with Weinreb amide (WA) functionality for the first time. The successful incorporation of the WA functionality has facilitated convenient access to unknown bis(styrylbenzenes) with acyl and formyl groups as substituents This strategy has also paved the way for highly functionalized bis(styrylbenzenes) with a tetrafluorophenyl core, which have potential as new contrast agents for MRI applications.
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TL;DR: Mechanistic investigation reveals that the C-H cleavage of arenes is the turnover-limiting step, and an acetate-bridged dinuclear cyclopalladation intermediate is involved.
143 citations
TL;DR: Under solvent control: Benzyl thioethers were alkenylated in excellent yields with broad substrate scope and the selectivity was controlled by the solvent and ratio of reactants.
Abstract: Under solvent control: Benzyl thioethers were alkenylated in excellent yields with broad substrate scope and the selectivity (mono- vs. disubstituted product) was controlled by the solvent and ratio of reactants. Sequential alkenylation with two different alkenes was also carried out in a one-pot process. In addition, the thioether directing group was removed in a one-pot process with simultaneous hydrogenation of the double bond to give the toluene derivatives.
99 citations
TL;DR: A mild, stereoselective, and quick approach to accessing alkynyl and alkenyl C-glycosides via BF(3)·Et(2)O promoted coupling of organotrifluoroborates and glycosyl fluorides is reported.
88 citations
TL;DR: A decade of research in the application of alkyne metathesis reactions in some of its variants to carbohydrates and carbohydrate-related compounds can be found in this article, where a review summarizes a decade of work in this area.
34 citations
TL;DR: In this paper, several new efficient synthetic approaches toward the natural product anti cancer agent varitriol, culminating in a concise total synthesis, are presented, which employ a new catalytic stereoselective vinyl oxirane ring expansion reaction, which provides rapid access to the common cis-2,5-tetrahydrofuran core.
31 citations