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Annamaria Cimini
Researcher at University of L'Aquila
Publications - 167
Citations - 4557
Annamaria Cimini is an academic researcher from University of L'Aquila. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Cancer. The author has an hindex of 31, co-authored 155 publications receiving 3368 citations. Previous affiliations of Annamaria Cimini include Gran Sasso National Laboratory & Istituto Nazionale di Fisica Nucleare.
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Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways.
Annamaria Cimini,Barbara D'Angelo,Soumen Das,Roberta Gentile,Elisabetta Benedetti,Virendra Singh,Antonina M. Monaco,Sandro Santucci,Sudipta Seal +8 more
TL;DR: PEG-coated and anti-Aβ antibody-conjugated antioxidant nanoparticles (Aβ-CNPs-PEG) are developed and their effects on neuronal survival and brain-derived neurotrophic factor (BDNF) signaling pathway were examined.
Journal ArticleDOI
Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance
Alessia Fidoamore,Loredana Cristiano,Andrea Antonosante,Michele d'Angelo,Erica Di Giacomo,Carlo Astarita,Antonio Giordano,Rodolfo Ippoliti,Elisabetta Benedetti,Annamaria Cimini +9 more
TL;DR: Recent evidences suggest that responses of glioblastoma to standard therapies are determined by the microenvironment of the niche, where the GSCs reside, allowing a variety of mechanisms that contribute to the chemo- and radioresistance, by preserving G SCs.
Journal ArticleDOI
Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons.
Annamaria Cimini,Elisabetta Benedetti,Loredana Cristiano,Pierluigi Sebastiani,M.A. D'Amico,Barbara D'Angelo,S. Di Loreto +6 more
TL;DR: The expression of PPARs and of their heterodimeric partners, RXRs, in embryonic rat cortical neurons during their in vitro maturation is analyzed and points toward the PPARbeta/delta isotype as a key factor in neuronal differentiation.
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Neuronal Cells Rearrangement During Aging and Neurodegenerative Disease: Metabolism, Oxidative Stress and Organelles Dynamic.
Vanessa Castelli,Elisabetta Benedetti,Andrea Antonosante,Mariano Catanesi,Giuseppina Pitari,Rodolfo Ippoliti,Annamaria Cimini,Annamaria Cimini,Michele d'Angelo +8 more
TL;DR: The first part of the review article will focus on the major neuronal cells’ rearrangements during aging in response to changes in metabolism and oxidative stress, while the second part will cover the neurodegenerative disease areas in detail.
Journal ArticleDOI
Cerium Oxide Nanoparticles Trigger Neuronal Survival in a Human Alzheimer Disease Model By Modulating BDNF Pathway
Barbara D'Angelo,Sandro Santucci,Elisabetta Benedetti,Silvia Di Loreto,R Phani,Stefano Falone,Fernanda Amicarelli,Maria Paola Cerù,Annamaria Cimini +8 more
TL;DR: The data obtained demonstrate that CeO2 nanoparticles do not act as mere anti-oxidant agents, but they seems to affect, directly or indirectly, signal transduction pathways involved in neuronal death and neuroprotection, raising the possibility of their use as therapeutic tools for neurodegenerative diseases.