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Anne-Christine Rat
Researcher at University of Lorraine
Publications - 97
Citations - 1860
Anne-Christine Rat is an academic researcher from University of Lorraine. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 20, co-authored 86 publications receiving 1630 citations. Previous affiliations of Anne-Christine Rat include Paris Descartes University & University of Paris.
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Journal ArticleDOI
Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity.
Damien Loeuille,Isabelle Chary-Valckenaere,Jacqueline Champigneulle,Anne-Christine Rat,Frédéric Toussaint,Astrid Pinzano-Watrin,Jean Christophe Goebel,D. Mainard,Alain Blum,J. Pourel,Patrick Netter,Pierre Gillet +11 more
TL;DR: MRI evaluation of synovitis could be used to classify OA patients in clinical trials and could help to identify those who could benefit from synovium-targeted therapy.
Journal ArticleDOI
Rheumatoid arthritis: direct and indirect costs.
TL;DR: Early effective treatment may not only postpone and slow disease progression, thereby improving quality of life, but also decrease costs by preserving productivity and reducing the need for surgery, admission to acute-care and extended-care hospitals, and social service utilization.
Journal ArticleDOI
OAKHQOL: a new instrument to measure quality of life in knee and hip osteoarthritis.
Anne-Christine Rat,Joël Coste,Jacques Pouchot,Michèle Baumann,E. Spitz,Nathalie Retel-Rude,Janine-Sophie Giraudet Le Quintrec,Dominique Dumont-Fischer,Francis Guillemin +8 more
TL;DR: The OAKHQOL is the first specific knee and hip OA quality of life instrument that meets psychometric requirements for validity and reliability and followed an a priori structured strategy to ensure content validity.
Journal ArticleDOI
Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene.
Laëtitia Michou,Sandra Lasbleiz,Anne-Christine Rat,Paola Migliorini,Alejandro Balsa,Rene Westhovens,Pilar Barrera,Helena Alves,Céline Pierlot,Elodie Glikmans,Sophie Garnier,Jean Dausset,Carlos Vaz,Manuela Fernandes,Elisabeth Petit-Teixeira,Isabelle Lemaire,Dora Pascual-Salcedo,Stefano Bombardieri,Jan Dequeker,Timothy R D J Radstake,Piet L. C. M. van Riel,Leo B A van de Putte,A. Lopes-Vaz,Bernard Prum,Thomas Bardin,Philippe Dieudé,François Cornélis +26 more
TL;DR: PTPN22–1858T allele is therefore a “linkage-proven” autoimmunity gene with diabetes and RA, demonstrating departure from Mendel's law in this subset of early RA onset patients.
Journal ArticleDOI
Cardiac manifestations of rheumatoid arthritis: a case-control transesophageal echocardiography study in 30 patients.
Claudie Guedes,Patricia Bianchi-Fior,Bertrand Cormier,Béatrice Barthelemy,Anne-Christine Rat,Marie-Christophe Boissier +5 more
TL;DR: It is demonstrated that cardiac involvement, particularly of the mitral valve, is extremely common in RA patients and no correlations linking cardiac lesions to clinical or laboratory features of RA are found.