Anne-Marie van Dam

TL;DR: The regional changes in microglial phenotype andTLR2 expression in primed/reactive microglia in the SN and HC of iLBD cases indicate that TLR2 may play a prominent role in the microglian-mediated responses that could be important for PD progression.

TL;DR: The relevance of brain (peri)vascular cells and compartments to bacterial meningitis, HIV-1-associated dementia, multiple sclerosis, ischaemic and traumatic brain injury, and Alzheimer's disease is discussed and a clear understanding of the role of these cytokines in both damaging and repair processes in the CNS is required.

TL;DR: Changes in neurogenesis in relation to exposure to stress, glucocorticoid hormones, and inflammation are discussed, with a particular focus on early development and on lasting effects of stress.

TL;DR: The study shows that oxidative injury and its triggering mechanisms diverge in different models of rodent central nervous system inflammation.

TL;DR: It is shown that the genetic profile of microglia already differs between different brain regions when studied under control conditions, which implies that brain region-specific microglial gene expression profiles exist that may contribute to the region- specific differences in microglian responsivity during disease conditions, such as seen in, e.g., PD.