A
Anne Tuukkanen
Researcher at University of Helsinki
Publications - 12
Citations - 405
Anne Tuukkanen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Cytochrome c oxidase & Heme A. The author has an hindex of 11, co-authored 12 publications receiving 329 citations.
Papers
More filters
Journal ArticleDOI
An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.
Diana Freire,Claude Gutierrez,Acely Garza-Garcia,Anna Grabowska,Ambre Sala,Kanchiyaphat Ariyachaokun,Terezie Panikova,Katherine S. H. Beckham,André Colom,Vivian Pogenberg,Michele Cianci,Anne Tuukkanen,Yves-Marie Boudehen,Antonio Peixoto,Laure Botella,Dmitri I. Svergun,Dirk Schnappinger,Thomas R. Schneider,Pierre Genevaux,Luiz Pedro S. de Carvalho,Matthias Wilmanns,Annabel H. A. Parret,Olivier Neyrolles +22 more
TL;DR: This study reports a new RES-Xre TA system in multiple human pathogens, including Mycobacterium tuberculosis, and uncovers a new class of enzymes that could be exploited to treat tuberculosis and other infectious diseases.
Journal ArticleDOI
A Coiled-Coil Domain Acts as a Molecular Ruler to Regulate O-Antigen Chain Length in Lipopolysaccharide.
Gregor Hagelueken,Bradley R. Clarke,Hexian Huang,Anne Tuukkanen,Iulia Danciu,Dmitri I. Svergun,Rohanah Hussain,Huanting Liu,Chris Whitfield,James H. Naismith +9 more
TL;DR: The coiled-coil domain of WbdD functions as a molecular ruler that, along with WbdA:WbdD stoichiometry, controls the chain length of a model bacterial polysaccharide.
Journal ArticleDOI
Charge translocation coupled to electron injection into oxidized cytochrome c oxidase from Paracoccus denitrificans.
TL;DR: It is confirmed that injection of the first electron into the fully oxidized cytochrome c oxidase from Paracoccus denitrificans is associated with a fast electrogenic 11 micros phase, and that it is accompanied by oxidation of heme a with a similar time constant.
Journal ArticleDOI
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity
Haipeng Liu,Haipeng Liu,Pedro Moura-Alves,Gang Pei,Hans-Joachim Mollenkopf,Robert Hurwitz,Xiangyang Wu,Fei Wang,Siyu Liu,Mingtong Ma,Yiyan Fei,Chenggang Zhu,Anne-Britta Koehler,Dagmar Oberbeck-Mueller,Karin Hahnke,Marion Klemm,Ute Guhlich-Bornhof,Baoxue Ge,Anne Tuukkanen,Michael Kolbe,Anca Dorhoi,Anca Dorhoi,Anca Dorhoi,Stefan H. E. Kaufmann,Stefan H. E. Kaufmann +24 more
TL;DR: Endocytosis facilitates internalization of eCDNs, and the DNA sensor cGAS facilitates sensing of endocytosed CDNs, their perinuclear accumulation, and subsequent STING‐dependent release of type I IFN.
Journal ArticleDOI
Structural insight into how Streptomyces coelicolor maltosyl transferase GlgE binds α-maltose 1-phosphate and forms a maltosyl-enzyme intermediate.
Karl Syson,Clare E. M. Stevenson,Abdul M. Rashid,Gerhard Saalbach,Minhong Tang,Anne Tuukkanen,Dmitri I. Svergun,Stephen G. Withers,David M. Lawson,Stephen Bornemann +9 more
TL;DR: The deeper understanding of the structure–function relationships of S. coelicolor GlgE will aid the development of inhibitors of the M. tuberculosis enzyme, and the glycosyl-enzyme intermediate structures determined have been obtained with a 2-deoxy-2-fluoro substrate analogue.