A
Anne-Ulrike Trendelenburg
Researcher at Novartis
Publications - 32
Citations - 1885
Anne-Ulrike Trendelenburg is an academic researcher from Novartis. The author has contributed to research in topics: Muscarinic acetylcholine receptor M3 & Muscarinic acetylcholine receptor M1. The author has an hindex of 21, co-authored 31 publications receiving 1587 citations.
Papers
More filters
Journal ArticleDOI
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.
Marc A. Egerman,Samuel M. Cadena,Jason A. Gilbert,Angelika Meyer,Hallie N. Nelson,Susanne E. Swalley,Carolyn Mallozzi,Carsten Jacobi,Lori L. Jennings,Ieuan Clay,Gaëlle Laurent,Shenglin Ma,Sophie Brachat,Estelle Lach-Trifilieff,Tea Shavlakadze,Anne-Ulrike Trendelenburg,Andrew S. Brack,David J. Glass +17 more
TL;DR: A GDF11-specific immunoassay is developed and a trend toward increased GDF 11 levels in sera of aged rats and humans is shown and GDF12 could be a target for pharmacologic blockade to treat age-related sarcopenia.
Journal ArticleDOI
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
Ana L. Cardoso,Adelaide Fernandes,Juan Antonio Aguilar-Pimentel,Martin Hrabé de Angelis,Joana R. Guedes,Maria Alexandra Brito,Saida Ortolano,Giovambattista Pani,Sophia Athanasopoulou,Efstathios S. Gonos,Markus Schosserer,Johannes Grillari,Pärt Peterson,Bilge Guvenc Tuna,Soner Dogan,Angelika Meyer,Ronald van Os,Anne-Ulrike Trendelenburg +17 more
TL;DR: Biomarker panels for frailty would be of high value and better than single markers.
Journal ArticleDOI
Treatment of sporadic inclusion body myositis with bimagrumab
Anthony A. Amato,Kumaraswamy Sivakumar,Namita Goyal,William S. David,Mohammad Salajegheh,Jens Praestgaard,Estelle Lach-Trifilieff,Anne-Ulrike Trendelenburg,Didier Laurent,David J. Glass,Ronenn Roubenoff,Brian Tseng,Steven A. Greenberg +12 more
TL;DR: This study provides Class I evidence that for patients with inclusion body myositis, bimagrumab increases thigh muscle volume at 8 weeks, and inhibition of ActRII increased muscle mass and function in this pilot trial, offering a potential novel treatment of sIBM.
Journal ArticleDOI
Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism
Brigitte Fournier,Ben Murray,Sabine Gutzwiller,Stefan Marcaletti,David Marcellin,Sebastian Bergling,Sophie Brachat,Elke Persohn,Eliane Pierrel,Florian Bombard,Shinji Hatakeyama,Anne-Ulrike Trendelenburg,Frederic Morvan,Brian Peter Richardson,David J. Glass,Estelle Lach-Trifilieff,Jerome N. Feige +16 more
TL;DR: It is demonstrated that the myostatin/activin receptor IIB (ActRIIB) pathway is also a negative regulator of brown adipocyte differentiation, which enhances mitochondrial function and uncoupled respiration, translating into beneficial functional consequences, including enhanced cold tolerance and increased energy expenditure.
Journal ArticleDOI
Presynaptic alpha 2-autoreceptors in brain cortex: alpha 2D in the rat and alpha 2A in the rabbit.
TL;DR: Comparison with data from the literature indicates that the rat brain autoreceptors can be equated with the α2D subtype as defined by radioligand binding, whereas the rabbit brain autoresceptors conform to theα2A subtype.