Annie-Claire Diserens

TL;DR: Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylation of theMGMT promoter did notHave such a benefit and were assigned to only radiotherapy.

TL;DR: The simultaneous status of TP53, p16, p14ARF and PTEN tumor suppressor genes in 34 randomly chosen human glioma cell lines provides the first clear genetic evidence that these tumor suppressors participate in biological pathways which are functioning separately/independently inglioma cells.

TL;DR: Results show that inactivation of the p53 gene is not an obligatory step in glioblastoma genesis, suggesting either that two pathways (p53 inactivation dependent or independent) may lead to a tumor group classified histologically as gliOBlastoma or that in some cases p53 mutations are bypassed due to the presence of mutations in downstream effector genes.

TL;DR: It is demonstrated that human gliomas can be differentiated according to their gene expression, and found that low-grade astrocytoma have the most specific and similar expression profiles, whereas primary glioblastoma exhibit much larger variation between tumors.

TL;DR: In this article, the authors demonstrate expression of interleukin (IL)-8, a cytokine with chemotactic and angiogenic properties, and of IL-8-binding receptors in human astrocytoma.