Author
Anocha Utaipat
Bio: Anocha Utaipat is an academic researcher from Mahidol University. The author has contributed to research in topics: Calyx & TBARS. The author has an hindex of 2, co-authored 2 publications receiving 323 citations.
Topics: Calyx, TBARS, Hibiscus sabdariffa, Antioxidant, Cholesterol
Papers
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TL;DR: The lines of evidence suggest that the aqueous extracts from the dried calyx of roselle possess both antioxidant effects against LDL oxidation and hypolipidemic effects in vivo, however, its mechanism(s) of action remains to be elucidated.
249 citations
TL;DR: It is demonstrated that the dried calyx extracts of roselle exhibits strong antioxidant activity in Cu(2+)-mediated oxidation of LDL (p<0.05) in vitro, and the inhibitory effect of the extracts on LDL oxidation was dose-dependent at concentrations ranging from 0.1 to 5 mg/ml.
Abstract: The present study quantitatively investigated the antioxidant effects of the aqueous extracts from dried calyx of Hibiscus sabdariffa LINN. (roselle) in vitro using rat low-density lipoprotein (LDL). Formations of the conjugated dienes and thiobarbituric acid reactive substances (TBARs) were monitored as markers of the early and later stages of the oxidation of LDL, respectively. Thus, we demonstrated that the dried calyx extracts of roselle exhibits strong antioxidant activity in Cu(2+)-mediated oxidation of LDL (p<0.05) in vitro. The inhibitory effect of the extracts on LDL oxidation was dose-dependent at concentrations ranging from 0.1 to 5 mg/ml. Moreover, 5 mg/ml of roselle inhibited TBARs-formation with greater potency than 100 microM of vitamin E. In conclusion, this study provides a quantitative insight into the potent antioxidant effect of roselle in vitro.
106 citations
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TL;DR: In vitro and in vivo studies as well as some clinical trials provide some evidence mostly for phytochemically poorly characterised Hs extracts which showed antibacterial, anti-oxidant, nephro- and hepato-protective, renal/diuretic effect, effects on lipid metabolism (anti-cholesterol), anti-diabetic and anti-hypertensive effects among others.
615 citations
Book•
06 Jul 2014
TL;DR: The authors suggest that the use of probiotics and prebiotics to modulate the gut flora composition in old age and the impact of dietary modulation of the gut microflora through dietary means should be considered.
Abstract: Plant secondary metabolites have been a fertile area of chemical investigation for many years, driving the development of both analytical chemistry and of new synthetic reactions and methodologies. The subject is multi-disciplinary with chemists, biochemists and plant scientists all contributing to our current understanding. In recent years there has been an upsurge in interest from other disciplines, related to the realisation that secondary metabolites are dietary components that may have a considerable impact on human health, and to the development of gene technology that permits modulation of the contents of desirable and undesirable components. Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet addresses this wider interest by covering the main groups of natural products from a chemical and biosynthetic perspective with illustrations of how genetic engineering can be applied to manipulate levels of secondary metabolites of economic value as well as those of potential importance in diet and health. These descriptive chapters are augmented by chapters showing where these products are found in the diet, how they are metabolised and reviewing the evidence for their beneficial bioactivity. © 2006 by Blackwell Publishing Ltd.
388 citations
TL;DR: The lines of evidence suggest that the aqueous extracts from the dried calyx of roselle possess both antioxidant effects against LDL oxidation and hypolipidemic effects in vivo, however, its mechanism(s) of action remains to be elucidated.
249 citations
TL;DR: Molecular evidence associated with the anti-metastatic effects of peonidin 3-glucoside and cyanidin3-gl Sucoside, major anthocyanins extracted from black rice, are provided by showing a marked inhibition on the invasion and motility of SKHep-1 cells in vivo.
235 citations
01 Feb 2009
TL;DR: Hibiscus sabdariffa linn is an annual herbaceous shrub, cultivated for its flowers although leaves and seeds have also been used in traditional medicine as discussed by the authors.
Abstract: Hibiscus sabdariffa Linn. is an annual herbaceous shrub, cultivated for its flowers although leaves and seeds have also been used in traditional medicine. The calyces of the plant are used as a refrigerant in the form of tea, to make jellies and jams. The plant is reported to contain proteins, fats, carbohydrates, flavonoids, acids, minerals and vitamins. The plant has been reported to have antihypertensive, hepatoprotective, antihyperlipidemic, anticancer and antioxidant properties. The present paper is an overview on its phytochemical and pharmacological properties reported in the literature.
215 citations