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Anoop Thomas

Bio: Anoop Thomas is an academic researcher. The author has an hindex of 1, co-authored 1 publications receiving 1 citations.

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Journal ArticleDOI
P Jaismy Jacob1, Anoop Thomas, S Venkataraman, E Hareeshbabu1, S L Manju 
01 Nov 2017
TL;DR: A novel class of substituted 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide synthesized by simple, modified Hantzsch condensation reaction using N-arylacetoacetamides, aryl aldehydes and ammonia exhibits significant antimicrobial activity along with antiulcer activity.
Abstract: A novel class of substituted 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide has been synthesized by simple, modified Hantzsch condensation reaction using N-arylacetoacetamides, aryl aldehydes and ammonia. Characterisation of the newly synthesized compounds was carried out by spectral analysis (IR, 1H NMR and Mass Spectroscopy). Antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans and antiulcer activity by aspirin induced and pyloric ligation ulcer model was studied. Results revealed that most of the compounds exhibit significant antimicrobial activity along with antiulcer activity. The compound 6i 4-dimethylamino phenyl group at 4th position of 1,4-dihydropyridine had shown 65% ulcer protection at 10 mg/kg administration in male albino rats.

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