A
Ante S. Lundberg
Researcher at Massachusetts Institute of Technology
Publications - 6
Citations - 4588
Ante S. Lundberg is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Telomerase reverse transcriptase & Telomere. The author has an hindex of 6, co-authored 6 publications receiving 4460 citations. Previous affiliations of Ante S. Lundberg include Brigham and Women's Hospital & Genzyme.
Papers
More filters
Journal ArticleDOI
Creation of human tumour cells with defined genetic elements
William C. Hahn,William C. Hahn,Christopher M. Counter,Ante S. Lundberg,Ante S. Lundberg,Roderick L. Beijersbergen,Mary W. Brooks,Robert A. Weinberg +7 more
TL;DR: It is shown that the ectopic expression of the telomerase catalytic subunit (hTERT) in combination with two oncogenes results in direct tumorigenic conversion of normal human epithelial and fibroblast cells.
Journal ArticleDOI
Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes
TL;DR: It is shown that endogenous D-type cyclins, acting with cdk4/6, are able to phosphorylate pRb only partially, a process that is likely to be completed by cyclin E-cdk2 complexes.
Journal ArticleDOI
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
Sheila A. Stewart,William C. Hahn,Benjamin F. O'Connor,Elisa N. Banner,Ante S. Lundberg,Poonam Modha,Hana Mizuno,Mary W. Brooks,Mark D. Fleming,Drazen B. Zimonjic,Nicholas C. Popescu,Robert A. Weinberg +11 more
TL;DR: It is indicated that hTERT confers an additional function that is required for tumorigenesis but does not depend on its ability to maintain telomere length.
Journal ArticleDOI
Genes involved in senescence and immortalization.
Ante S. Lundberg,William C. Hahn,William C. Hahn,William C. Hahn,Piyush Gupta,Robert A. Weinberg +5 more
TL;DR: The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence are being further elucidated.
Journal ArticleDOI
Immortalization and transformation of primary human airway epithelial cells by gene transfer.
Ante S. Lundberg,Scott H. Randell,Sheila A. Stewart,Brian Elenbaas,Brian Elenbaas,Kimberly A. Hartwell,Mary W. Brooks,Mark D. Fleming,John C. Olsen,Scott W Miller,Robert A. Weinberg,William C. Hahn,William C. Hahn,William C. Hahn +13 more
TL;DR: These immortalized human airways epithelial cells, which have been created through the stepwise introduction of genetic alterations, provide a novel experimental model system with which to study further the biology of the airway epithelial cell and to dissect the molecular basis of lung cancer pathogenesis.