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Anthony A. Luciano

Bio: Anthony A. Luciano is an academic researcher from University of Connecticut. The author has contributed to research in topics: Endometriosis & Laparoscopy. The author has an hindex of 36, co-authored 94 publications receiving 3907 citations. Previous affiliations of Anthony A. Luciano include University of Connecticut Health Center.


Papers
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TL;DR: For three consecutive menstrual cycles, subjects collected daily urine samples for analysis of FSH, estrone conjugates (E1C), pregnanediol-3-glucuronide (PdG), and creatinine (Cr) as discussed by the authors.
Abstract: The purposes of this investigation were to evaluate the characteristics of three consecutive menstrual cycles and to determine the frequency ofluteal phase deficiency (LPD) and anovulation in a sample of sedentary and moderately exercising, regularly menstruating women For three consecutive menstrual cycles, subjects collected daily urine samples for analysis of FSH, estrone conjugates (E1C), pregnanediol-3-glucuronide (PdG), and creatinine (Cr) Sedentary (n=11) and exercising (n=24) groups were similar in age (270+/-13 yr), weight (603+/-31 kg), gynecological age (138+/-12 yr), and menstrual cycle length (283+/-08 days) Menstrual cycles were classified by endocrine data as ovulatory, LPD, or anovulatory No sedentary women (0%) had inconsistent menstrual cycle classifications from cycle to cycle, but 46% of the exercising women were inconsistent The sample prevalence of LPD in the exercising women was 48%, and the 3-month sample incidence was 79% In the sedentary women, 90% of all menstrual cycles were ovulatory (SedOvul; n=28), whereas in the exercising women only 45% were ovulatory (ExOvul; n=30); 43% were LPD (ExLPD; n=28), and 12% were anovulatory (ExAnov; n=8) In ExLPD cycles, the follicular phase was significantly longer (179+/-07 days), and the luteal phase was significantly shorter (82+/-05 days) compared to ExOvul (148+/-09 and 129+/-03 days) and SedOvul (159+/-06 and 129+/-04 days) cycles Luteal phase PdG excretion was lower (P < 0001) in ExLPD (29+/-03 microg/mg Cr) and ExAnov (08+/-01 microg/mg Cr) cycles compared to SedOvul cycles (50+/-04 microg/mg Cr) ExOvul cycles also had less (P < 001) PdG excretion during the luteal phase (37+/-03 microg/mg Cr) than the SedOvul cycles E1C excretion during follicular phase days 2-5 was lower (P=005) in ExOvul, ExLPD, and ExAnov cycles compared to SedOvul cycles and remained lower (P < 002) in the ExLPD and ExAnov cycles during days 6-12 The elevation in FSH during the luteal-follicular transition was lower (P < 0007) in ExLPD (07+/-01 ng/mg Cr) cycles compared to SedOvul and ExOvul cycles (10+/-01 and 11+/-01 ng/mg Cr, respectively) Energy balance and energy availability were lower (P < 005) in ExAnov cycles than in other menstrual cycle categories The blunted elevation in FSH during the luteal-follicular transition in exercising women with LPD may explain their lower follicular estradiol levels These alterations in FSH may act in concert with disrupted LH pulsatility as a primary and proximate factor in the high frequency of luteal phase and ovulatory disturbances in regularly menstruating, exercising women

314 citations

Journal ArticleDOI
TL;DR: Management of endometriosis focuses on pain relief and includes medical and surgical treatment, and newer options for treatment include depot medroxyprogesterone acetate subcutaneous injection, as well as several agents under investigation that may prove to have therapeutic potential.
Abstract: Endometriosis is a chronic and recurrent disease characterized by the presence and proliferation of endometrial tissue outside the uterine cavity, which occurs in approximately 10% of women of reproductive age. In this estrogen-dependent disorder, lesions become inactive and gradually undergo regression during states of ovarian down-regulation, such as amenorrhoea or menopause. The impact of endometriosis includes impaired fertility potential, as well as symptoms of dysmenorrhoea, dyspareunia and chronic non-menstrual pain, all of which adversely affect quality of life. Management of endometriosis focuses on pain relief and includes medical and surgical treatment. Pharmacologic therapies currently in use include combination oral contraceptives (COCs), danazol, GnRH analogues and progestins. Although some agents show efficacy in relieving pain, all differ in their side effects, making it difficult to achieve a balance between efficacy and safety. Efficacy has been demonstrated with danazol or GnRH analogues; however, treatment is limited to 6 months because of significant metabolic side effects. Alternatives for longer-term management of symptoms include add-back therapy with GnRH analogues, COCs or progestins. Newer options for treatment of endometriosis include depot medroxyprogesterone acetate subcutaneous injection, as well as several agents under investigation that may prove to have therapeutic potential.

218 citations

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TL;DR: This is the first randomized, double-blind trial of an adhesion reduction agent and demonstrated that Adept is a safe and effective adhesion Reduction agent in laparoscopy.

206 citations

Journal Article
TL;DR: Clinical observation that besides reducing operative trauma, discomfort, and cost, laparoscopic laser surgery is very effective in reducing intraperitoneal adhesions and causes significantly less postoperative adhesion formation than does laparotomy is confirmed.

168 citations

Journal ArticleDOI
TL;DR: Data indicate that a species of Prolactin which is identical to pituitary prolactin by the criteria of immunoprecipitation and gel chromatography is synthesized by human decidual tissue in vitro.

154 citations


Cited by
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Journal ArticleDOI
TL;DR: The purpose of this review is to provide a comprehensive survey of the current understanding of prolactin's function and its regulation and to expose some of the controversies still existing.
Abstract: Prolactin is a protein hormone of the anterior pituitary gland that was originally named for its ability to promote lactation in response to the suckling stimulus of hungry young mammals. We now know that prolactin is not as simple as originally described. Indeed, chemically, prolactin appears in a multiplicity of posttranslational forms ranging from size variants to chemical modifications such as phosphorylation or glycosylation. It is not only synthesized in the pituitary gland, as originally described, but also within the central nervous system, the immune system, the uterus and its associated tissues of conception, and even the mammary gland itself. Moreover, its biological actions are not limited solely to reproduction because it has been shown to control a variety of behaviors and even play a role in homeostasis. Prolactin-releasing stimuli not only include the nursing stimulus, but light, audition, olfaction, and stress can serve a stimulatory role. Finally, although it is well known that dopamine of hypothalamic origin provides inhibitory control over the secretion of prolactin, other factors within the brain, pituitary gland, and peripheral organs have been shown to inhibit or stimulate prolactin secretion as well. It is the purpose of this review to provide a comprehensive survey of our current understanding of prolactin's function and its regulation and to expose some of the controversies still existing.

2,193 citations

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TL;DR: To critically review the risks and benefits of hormone therapy for asymptomatic postmenopausal women who are considering long-term hormone therapy to prevent disease or to prolong life-long hormone therapy is critically reviewed.
Abstract: ▪Purpose:To critically review the risks and benefits of hormone therapy for asymptomatic postmenopausal women who are considering long-term hormone therapy to prevent disease or to prolong...

2,172 citations

Journal ArticleDOI
TL;DR: This guideline was produced by a group of experts in the field using the structured methodology of the Manual for ESHRE Guideline Development, including a thorough systematic search of the literature, quality assessment of the included papers up to January 2012 and consensus within the guideline group on all recommendations.
Abstract: studydesign,size,duration: This guideline was produced by a group of experts in the field using the methodology of the Manual for ESHRE Guideline Development, including a thorough systematic search of the literature, quality assessment of the included papers up to January 2012 and consensus within the guideline group on all recommendations. To ensure input from women with endometriosis, a patient representative was part of the guideline development group. In addition, patient and additional clinical input was collected during the scoping and review phase of the guideline.

1,641 citations

DOI
18 Feb 2015

1,457 citations

Journal ArticleDOI
TL;DR: A picture has emerged depicting the classic endocrine control of ovarian function by LH and FSH, entangled in a maze of regulatory systems hinging on cell-cell interactions between follicular cells, via action of a variety of molecules.
Abstract: I. Introduction IN THE adult ovary, folliculogenesis starts when follicles leave the pool of resting follicles (RF) to enter the growth phase. From there, the early growing follicle undergoes a developmental process including a dramatic course of cellular proliferation and differentiation. In primates, only one follicle commonly reaches the preovulatory stage every cycle; most follicles fail to complete this maturation scheme, dying in the process termed atresia. In recent years, a picture has emerged depicting the classic endocrine control of ovarian function by LH and FSH, entangled in a maze of regulatory systems hinging on cell-cell interactions between follicular cells, via action of a variety of molecules (1–3). Different types of cell-cell interactions have been described. In paracrine regulations, a molecule synthesized by one cellular type is released into the interstitial milieu to act directly on another cellular type. In autocrine regulations, molecules synthesized by one cellular type are rel...

1,410 citations