A
Anthony C. Gordon
Researcher at Imperial College London
Publications - 170
Citations - 14289
Anthony C. Gordon is an academic researcher from Imperial College London. The author has contributed to research in topics: Intensive care & Septic shock. The author has an hindex of 42, co-authored 149 publications receiving 8651 citations. Previous affiliations of Anthony C. Gordon include University of British Columbia & Imperial College Healthcare.
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Journal ArticleDOI
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.
Sterne Jac.,Srinivas Murthy,Janet V. Diaz,Arthur S. Slutsky,Judit Villar,Derek C. Angus,Djillali Annane,Azevedo Lcp.,Otavio Berwanger,Alexandre Biasi Cavalcanti,Dequin P-F.,Dequin P-F.,Bin Du,Jonathan Emberson,David Fisher,Bruno Giraudeau,Anthony C. Gordon,Anders Granholm,Cameron Green,Richard Haynes,N Heming,Higgins Jpt.,Higgins Jpt.,Peter Horby,Peter Jüni,Martin J Landray,A. Le Gouge,Marie Leclerc,Wei Shen Lim,Flávia Ribeiro Machado,Colin McArthur,Colin McArthur,Ferhat Meziani,Morten Hylander Møller,Anders Perner,M W Petersen,Jelena Savović,Jelena Savović,Bruno Martins Tomazini,Viviane C Veiga,Steven A R Webb,John C. Marshall +41 more
TL;DR: A prospective meta-analysis that pooled data from 7 randomized clinical trials that evaluated the efficacy of corticosteroids in 1703 critically ill patients with COVID-19 found that low-dose dexamethasone reduced mortality in hospitalized patients with Cohen's disease who required respiratory support.
Journal ArticleDOI
Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock
James A. Russell,Keith R. Walley,Joel Singer,Anthony C. Gordon,Paul C. Hébert,D. James Cooper,Cheryl L. Holmes,Sangeeta Mehta,John Granton,Michelle Storms,Deborah J. Cook,Jeffrey J. Presneill,Dieter Ayers +12 more
TL;DR: Low-dose vasopressin did not reduce mortality rates as compared with norepinephrine among patients with septic shock who were being treated with conventional (catecholamine) vasopressesors, and a test for heterogeneity between these two study strata was not significant.
Journal ArticleDOI
Genetic mechanisms of critical illness in Covid-19.
Erola Pairo-Castineira,Erola Pairo-Castineira,Sara Clohisey,Lucija Klaric,Andrew D. Bretherick,Konrad Rawlik,Dorota Pasko,Susan P. Walker,Nicholas J. Parkinson,Max Head Fourman,Clark D Russell,James J Furniss,Anne Richmond,E. Gountouna,Nicola Wrobel,David A Harrison,B. Wang,Yang Wu,A. Meynert,Fiona Griffiths,Wilna Oosthuyzen,Athanasios Kousathanas,Loukas Moutsianas,Z. Yang,R. Zhai,Canbin Zheng,Graeme R. Grimes,Rupert Beale,Jonathan E Millar,Barbara Shih,Seán Keating,Marie Zechner,Chris Haley,David J. Porteous,Caroline Hayward,Jian Yang,Julian C. Knight,Charlotte Summers,Manu Shankar-Hari,Manu Shankar-Hari,Paul Klenerman,Lance Turtle,Antonia Ho,S. C. Moore,Charles J. Hinds,P. Horby,Alistair Nichol,Alistair Nichol,Alistair Nichol,David M. Maslove,Lowell Ling,Daniel F. McAuley,Hugh Montgomery,Timothy S. Walsh,Alexandre C. Pereira,Alessandra Renieri,C. Ponting,J. Meikle,P. Finernan,E. Mcmaster,E. Mcmaster,Andy Law,J. K. Baillie,T. Paterson,T. Wackett,Robert C. Armstrong,Robert C. Armstrong,R. Clark,A. Coutts,L. Donnelly,Tamara Gilchrist,K. Hafezi,K. Hafezi,L. Macgillivray,L. Macgillivray,Alan MacLean,Sarah McCafferty,Kirstie Morrice,J. Weaver,C. Boz,C. Boz,A. Golightly,Minghong Ward,H. Mal,H. Szoor-McElhinney,Anthony Brown,Ross Hendry,A. Stenhouse,L. Cullum,D. Law,S. Law,R. Law,Maaike C. Swets,N. Day,F. Taneski,Emma L. Duncan,David Collier,S. Wood,A. Zak,C. Borra,M. Matharu,P. May,Z. Alldis,O. Mitchelmore,R. Bowles,A. Easthope,F. Bibi,I. Lancoma-Malcolm,J. Gurasashvili,J. Pheby,J. Shiel,M. Bolton,Minal Patel,M. Taylor,O. Zongo,P. Ebano,P. Harding,R. Astin-Chamberlain,Y. Choudhury,Anna Cox,D. Kallon,M. Burton,R. Hall,S. Blowes,Z. Prime,J. Biddle,O. Prysyazhna,T. Newman,C. Tierney,J. Kassam,Marlies Ostermann,S. Campos,A. Bociek,R. Lim,N. Grau,T. O. Jones,C. Whitton,M. Marotti,Gill Arbane,S. Bonner,K. Hugill,J. Reid,Ingeborg Welters,V. Waugh,Katherine Williams,D. Shaw,J. F. Roman,M. L. Martinez,Elizabeth M. Johnson,A. Waite,B. Johnston,D. Hamilton,S. Mulla,Mark J. W. McPhail,John A. S. Smith,L. Barclay,D. Hope,Corrienne McCulloch,L. McQuillan,S. Clark,J. Singleton,K. Priestley,N. Rea,M. Callaghan,R. Campbell,G. Andrew,L. Marshall,Stuart McKechnie,P. Hutton,A. Bashyal,N. Davidson,P. Polgarova,K. Stroud,N. Pathan,K. Elston,Sutapa Agrawal,Ceri Battle,L. Newey,Tim Rees,R. Harford,E. Brinkworth,Martin S. Williams,C. Murphy,I. M. S. White,M. Croft,N. Bandla,M. Gellamucho,J. Tomlinson,H. Turner,Michael Davies,A. Quinn,I. Hussain,Christopher C. Thompson,H. Parker,R. Bradley,R. Griffiths,J. Scriven,A. Nilsson,Matthew G.D. Bates,J. Dasgin,Janusz Gill,Alex Puxty,S. Cathcart,D. Salutous,L. Turner,K. Duffy,K. Puxty,Anna Maria Joseph,R. Herdman-Grant,R. Simms,A. Swain,A. Naranjo,R. Crowe,K. Sollesta,A. Loveridge,D. Baptista,E. Morino,M. Davey,D. Golden,J. Jones,J. Moreno Cuesta,A. Haldeos,D. Bakthavatsalam,Royce P Vincent,M. Elhassan,K. Xavier,Anand K. Ganesan,D. Purohit,M. Abdelrazik,J.M. Morgan,L. Akeroyd,S. Bano,T. Lawton,D. Warren,M. Bromley,K. Sellick,L. Gurr,B. Wilkinson,V. Nagarajan,P. Szedlak,Jason Cupitt,E. Stoddard,L. Benham,S. Preston,Shondipon Laha,N. Slawson,Z. Bradshaw,Jamie Brown,M. Caswell,S. Melling,P. Bamford,M. Faulkner,K. Cawley,H. Jeffrey,E. London,H. Sainsbury,I. Nagra,F. Nasir,C. Dunmore,R. L. Jones,A. Abraheem,M. Al-Moasseb,R. Girach,G. Padden,Josephine M. Egan,C. Brantwood,P. Alexander,J. Bradley-Potts,Susan Allen,Timothy Felton,S. Manna,S. Farnell-Ward,S. Leaver,J. Queiroz,E. Maccacari,D. Dawson,C. C. Delgado,R. P. Saluzzio,O. Ezeobu,L. Ding,C. Sicat,R. Kanu,G. Durrant,J. Texeira,Abby Harrison,T. Samakomva,H. Willis,B. Hopkins,L. Thrasyvoulou,M. Jackson,A. Zaki,C. Tibke,Suzanne Bennett,W. Woodyatt,A. Kent,E. Goodwin,C. Brandwood,Lee B. Smith,Kevin Rooney,Neil C. Thomson,N. Rodden,Ellen C Hughes,D. McGlynn,C. Clark,P. Clark,Laurent Abel,R. Sundaram,L. Gemmell,M. Brett,J. Hornsby,P. MacGoey,R. Price,B. Digby,P. O'Neil,P. McConnell,Paul Henderson,Seton J Henderson,M. Sim,S. Kennedy-Hay,C. McParland,L. Rooney,N. Baxter,D. Pogson,S. Rose,Z. Daly,L. Brimfield,Mandeep Phull,M. Hussain,T. Pogreban,L. Rosaroso,E. Salciute,L. Grauslyte,David Brealey,Eamon P. Raith,N. MacCallum,G. Bercades,I. Hass,D. Smyth,A. Reyes,G. Martir,I. D. Clement,K. Webster,C. Hays,A. Gulati,Luke Hodgson,M. Margarson,Refujia Gomez,Y. Baird,Y. Thirlwall,L. Folkes,A. Butler,E. Meadows,Shona C Moore,D. Raynard,Helen C. Fox,L. Riddles,K. King,S. Kimber,G. Hobden,Anne Marie McCarthy,V. Cannons,I. Balagosa,I. Chadbourn,A. Gardner,D. Horner,D. McLaughlanv,B. Charles,N. Proudfoot,T. Marsden,L. McMorrow,B. Blackledge,J. Pendlebury,Alison G. Harvey,E. Apetri,C. Basikolo,L. Catlow,R. Doonan,K. Knowles,S. Lee,David A. Lomas,C. Lyons,Joseph Perez,M. Poulaka,M. Slaughter,K. Slevin,V. Thomas,David W. Walker,Jennifer R. Harris,A. Drummond,R. Tully,J. Dearden,J. Philbin,S. Munt,C. Rishton,G. O'Connor,M. Mulcahy,E. Dobson,J. Cuttler,M. Edward,Jill M. Norris,K. Hanson,Alexis Poole,Alistair Rose,B. Sloan,S. Buckley,H. Brooke,E. Smithson,R. Charlesworth,R. Sandhu,M. Thirumaran,V. Wagstaff,J. C. Suarez,Agilan Kaliappan,M. Vertue,Andrew G. Nicholson,J. Riches,A. Solesbury,L. Kittridge,M. Forsey,G. Maloney,John B. Cole,R. Davies,H. Hill,E L Thomas,A. Williams,D. Duffin,B. Player,Jayachandran Radhakrishnan,Spencer B. Gibson,A. Lyle,F. McNeela,Brijesh V. Patel,M. Gummadi,G. Sloane,N. Dormand,S. Salmi,Z. Farzad,D. Cristiano,K. Liyanage,V. Thwaites,M. Varghese,M. Meredith,Gordon B. Mills,J. Willson,K. Harrington,B. Lenagh,K. Cawthron,S. Masuko,A. Raithatha,K. Bauchmuller,M. Wiles,N. Ahmad,Jack Barker,Y. Jackson,F. Kibutu,Sara W. Bird,G. Watson,Javier Martin,E. Bevan,C. W. Brown,D. Trodd,K. English,Graeme I. Bell,L. Wilcox,A. Katary,S. Gopal,V. Lake,N. Harris,S. Metherell,Elizabeth J. Radford,F. Moore,H. Bancroft,J. Daglish,M. Sangombe,M. Carmody,Johanna Rhodes,M. Bellamy,Atul Garg,A. Kuravi,E. Virgilio,P. Ranga,Javed Butler,L. Botfield,C. Dexter,Jason Fletcher,P. Shanmugasundaram,G. Hambrook,I. Burn,K. Manso,D. Thornton,J. Tebbutt,R. Penn,J. Hulme,Sabah N. A. Hussain,Z. Maqsood,Sarah B. Joseph,J. Colley,A. Hayes,C. Ahmed,R. Haq,S. Clamp,Rakesh Kumar,M. Purewal,B. Baines,M. Frise,N. Jacques,H. Coles,J. Caterson,S. G. Rai,M. Brunton,E. Tilney,L. Keating,Andrew Walden,David Antcliffe,Stephen J. Brett,Anthony C. Gordon,M. Templeton,Rocio Rojo,D. Banach,S. S. Arias,Z. Fernandez,P. Coghlan,D. Williams,Catherine Jardine,J. Bewley,Katie Sweet,L. Grimmer,Randall S. Johnson,Z. Garland,B. Gumbrill,C. Phillips,L. Ortiz-Ruiz de Gordoa,E. Peasgood,Ascanio Tridente,K. Shuker,S. Greer,C. Lynch,C. Pothecary,L. Roche,B. Deacon,K. Turner,Jai Rup Singh,G. S. Howe,P. Paul,Michael Gill,I. Wynter,V. Ratnam,S. Shelton,Jay Naisbitt,J. Melville,R. Baruah,Siouxzy Morrison,A. McGregor,V. Parris,M. Mpelembue,S. Srikaran,C. Dennis,A. Sukha,M. Verlander,K. Holding,K. Riches,C. Downes,C. Swan,A. Rostron,Ajit Roy,L. Woods,S. Cornell,F. Wakinshaw,Ben Creagh-Brown,H. Blackman,A. Salberg,E. N. Smith,S. Donlon,S. Mtuwa,N. Michalak-Glinska,S. Stone,C. Beazley,V. Pristopan,N. Nikitas,L. Lankester,Christine A. Wells,A. S. Raj,Katherine Fletcher,R. Khade,G. Tsinaslanidis,Michael MacMahon,Stephen J. Fowler,T. Coventry,Richard B. Stewart,L. Wren,E. Mwaura,L. Mew,D. Scaletta,Frances M K Williams,K. Inweregbu,N. Lancaster,Matthew Cunningham,A. Daniels,L. Harrison,S. Hope,S Jones,A. Crew,G. Wray,John N. S. Matthews,R. Crawley,J. Carter,I. Birkinshaw,J. Ingham,Z. Scott,H. Pearson,K. Howard,R. Joy,S. Roche,M. Clark,S. Purvis,Alanna C. Morrison,David P. Strachan,S. Clements,K. Black,Chetan Parmar,A. Altabaibeh,Kenneth J. Simpson,L. Mostoles,K. Gilbert,L. Ma,A. Alvaro,Mark G. Thomas,B. Faulkner,R. Worner,Kate Hayes,E. Gendall,H. Blakemore,B. Borislavova,E. Goff,Alan Vuylsteke,L. Mwaura,J. Zamikula,L Garner,A. Mitchell,S. Mepham,L. Cagova,A. Fofano,H. Holcombe,K. Praman,Tamas Szakmany,A. E. Heron,S. Cherian,S. Cutler,A. Roynon-Reed,G. Randell,K. Convery,K. Stammers,D. Fottrell-Gould,L. Hudig,J. Keshet-Price,Mark J. Peters,L. O'Neill,Swapan K. Ray,H. Belfield,T. McHugh,Graeme Jones,O. Akinkugbe,A. Tomas,E. Abaleke,E. Beech,H. Meghari,S. Yussuf,A. Bamford,B. Hairsine,E. Dooks,F. Farquhar,S. Packham,H. Bates,Lawrence Armstrong,C. Kaye,A. Allan,J. Medhora,J. Liew,A. Botello,F. Anderson,Rebecca Cusack,H. Golding,K. Prager,Thomas N. Williams,S. Leggett,K. Golder,M. Male,O. Jones,K. Criste,M. Marani,V. Anumakonda,V. Amin,K. Karthik,R. Kausar,E. Anastasescu,K. Reid,Mari Smith,Anil Hormis,Rosie M. Walker,T. Duncan,A. Uriel,Andrew Ustianowski,H. T-Michael,M. Bruce,K. Connolly,Kenneth Smith,Roland Partridge,Darren K. Griffin,M. Mupudzi,N. Muchenje,Dori-Ann Martin,H. Filipe,C. Eastgate,C. Jackson,Andrew Gratrix,L. Foster,Victoria Martinson,E. Stones,C. Abernathy,P. Parkinson,A. Reed,C. Prendergast,Peter Rogers,M. Woodruff,R. Shokkar,S Kaul,A. Barron,C. Collins,S. Beavis,A. Whileman,K. Dale,J. Hawes,K. Pritchard,R. Gascoyne,L. Stevenson,R. Jha,L. Lim,V. Krishnamurthy,Roy Parker,I. Turner-Bone,L. Wilding,A. Reddy,S. Whiteley,E. Wilby,C. Howcroft,A. Aspinwall,Sue Charlton,B. Ogg,Donna J. Menzies,Richard Pugh,E. Allan,R. Lean,F. Davies,J. Easton,X. Qiu,Shriya B. Kumar,K. Darlington,G. Houston,P. O'Brien,T. Geary,Jay Allan,A. Meikle,Grant L. Hughes,M. Balasubramaniam,S. Latham,E. McKenna,R. Flanagan,S. Sathe,Emma L. Davies,M. Chablani,A. Kirkby,K. Netherton,S. Archer,Bryan Yates,C. Ashbrook-Raby,Sarah Cole,M. Casey,L. Cabrelli,Stephen Chapman,A. Hutcheon,C. Whyte,C. Almaden-Boyle,Natalie Pattison,Claudina Cruz,A. Vochin,H. Kent,Adri A. M. Thomas,S. Murdoch,B. David,M. Penacerrada,G. Lubimbi,V. Bastion,R. Wulandari,Roberto Lorusso,J. Valentine,D. Clarke,A. Serrano-Ruiz,S. Hierons,C. Eckbad,L. Ramos,C. Demetriou,S. Mitchard,K. White,Nicholas J. White,Steven J. Pitts,D. Branney,J. Frankham,M. Watters,H. Langton,Rachel Prout,V. Page,T. Varghes,A. Cowton,A. Kay,K. Potts,M. Birt,Matthew Peter Kent,A. Wilkinson,E. B. Jude,V. Turner,H. Savill,J. McCormick,M. Coulding,S. Siddiqui,O. Mercer,H. Rehman,D. Potla,N. Capps,David S. Donaldson,H. Button,Terry Martin,K. Hard,A. Agasou,L. Tonks,T. Arden,Patricia A. Boyle,M. Carnahan,J. Strickley,Christopher M. Adams,D. Childs,R. Rikunenko,M. Leigh,M. Breekes,R. Wilcox,A. Bowes,H. Tiveran,F. Hurford,J. Summers,Austin Carter,Y. Hussain,L. Ting,A. Javaid,N. Motherwell,H. Moore,H. Millward,S. Jose,N. Schunki,A. Noakes,C. Clulow,G. Sadera,Reni Jacob,Chris Jones,M. Blunt,Z. Coton,H. Curgenven,S. M. Ally,K. Beaumont,M. Elsaadany,K. Fernandes,I. Ali Mohamed Ali,H. Rangarajan,V. Sarathy,S. Selvanayagam,D. Vedage,M. White,N. Truman,Srikanth Chukkambotla,S. Keith,J. Cockerill-Taylor,J. Ryan-Smith,R. Bolton,P. Springle,J. Dykes,Jo Thomas,Muzamil Majid Khan,M. T. Hijazi,E. Massey,G. Croston,Henrik Reschreiter,Julie Camsooksai,S. Patch,S. Jenkins,C. Humphrey,B. Wadams,M. Msiska,O. Adanini,B. Attwood,P. Parsons,Kate Tatham,S. Jhanji,E. Black,A. Dela Rosa,R. Howle,B. Thomas,T. Bemand,R. Raobaikady,R. Saha,Nikki Staines,A. Daniel,J. Finn,J. Hutter,P. Doble,C. Shovelton,C. Pawley,T. Kannan,Michael Hill,E. Combes,S. Monnery,T. Joefield,M. Popescu,M. Thankachen,M. Oblak,Jeff Little,S. McIvor,A. Brady,H. Whittle,H. Prady,R. Chan,A. Ahmed,Andrew D. Morris,C. Gibson,E. Gordon,S. Keenan,H. Quinn,S. Benyon,S. Marriott,L. Zitter,L. Park,K. Baines,M. Lyons,M. Holland,N. Keenan,M. Young,S. Garrioch,J. Dawson,M. Tolson,B. Scholefield,R. Bi,Neil Richardson,N. Schumacher,T. Cosier,G. Millen,A. Higham,S. Turki,L. Allen,N. Crisp,T. Hazleton,A. Knight,J. Deery,C. Price,S. Turney,S. Tilbey,E. Beranova,Derek W. Wright,L. George,S. Twiss,S. Wadd,K. Postlethwaite,P. Gondo,B. Masunda,A. Kayani,B. Hadebe,J. Whiteside,N. Clarke,Phil Donnison,F. Trim,I. Leadbitter,D. Butcher,S. O'Sullivan,B. Purewal,Scott C. Bell,V. Rivers,R. O'Leary,J. Birch,E. Collins,Stephen K. Anderson,K. Hammerton,E. Andrews,K. Burns,I. Edmond,A. Todd,J. Donnachie,P. Turner,L. Prentice,L. Symon,N. Runciman,F. Auld,M. Halkes,P. Mercer,L. Thornton,G. Debreceni,J. Wilkins,V. Crickmore,G. Subramanian,Robert Marshall,C. Jennings,M. Latif,L. Bunni,M. Spivey,S. Bean,K. Burt,Vanessa Linnett,J. Ritzema,A. Sanderson,W. McCormick,M. Bokhari,R. Kapoor,D. Loader,A. Ayers,W. Harrison,J. North,Z. Belagodu,R. Paramsothy,O. Olufuwa,A. Gherman,B. Fuller,C. Stuart,O. Kelsall,Carrie A. Davis,L. Wild,Henry Wood,Jessica Thrush,A. Durie,K. Austin,K. Archer,P. Anderson,C. Vigurs,C. Thorpe,E. Knights,N. Boyle,Alkes L. Price,A. Kubisz-Pudelko,D. Wood,Amy Lewis,S. Board,L. Pippard,John R. B. Perry,K. Beesley,A. Rattray,E. Lee,L. Lennon,K. Douglas,D. Bell,R. Boyle,L. Glass,M. Nauman Akhtar,K. Dent,D. Potoczna,S. Pearson,E. Horsley,S. Spencer,D. Mullan,D. Skinner,J. Gaylard,R. Barber,C. Hewitt,A. Hilldrith,S. Shepardson,M. Wills,K. Jackson-Lawrence,A. Gupta,E. Timlick,C. Gorman,Igor Otahal,A. Gales,S. Coetzee,Christian Sell,M. Raj,M. Peiu,S. Quaid,E. Watson,Katherine S. Elliott,J. Mallinson,B. Chandler,A. Turnbull,C. Finch,C. Holl,J.A. Cooper,Anthony Evans,W. Khaliq,Andrea M. Collins,E. T. Gude,N. Love,L. van Koutrik,John A. Hunt,D. Kaye,Eva Fisher,A. Brayne,V. Tuckey,P. Jackson,J. Parkin,A. Tariq,Henry Houlden,A. Tucci,John Hardy,E. Moncur,J. Highgate,A. Cowley,A. Mitra,R. Stead,T. Behan,C. Burnett,M. Newton,E. Heeney,R. Pollard,J. Hatton,Amita Patel,Vidya Kasipandian,S. Allibone,R. M. Genetu,L. O'Brien,Z. Omar,E. Perkins,Kevin A. Davies,D. Tetla,B. Shelley,V. Irvine,Samantha J. Williams,Patricia Williams,J. Goodsell,R. Tutton,L. Bough,B. Winter-Goodwin,R. Kitson,J. Pinnell,Anthony J. Wilson,T. Nortcliffe,T. Wood,M. Home,K. Holdroyd,Matthew R. Robinson,R. Shaw,J. Greig,M. Brady,A. Haigh,L. Matupe,M. Usher,S. Mellor,S. Dale,L. Gledhill,L. Shaw,G. Turner,Donna Kelly,B. Anwar,Heather L. Riley,H. Sturgeon,A. Ali,L. Thomis,D. Melia,A. Dance,SE Humphreys,I. Frost,V. Gopal,Jo Godden,A. Holden,S. Swann,Tony Smith,M. Clapham,U. Poultney,R. Harper,P. Rice,R. Reece-Anthony,B. Gurung,S. Moultrie,M. Odam,Andreas Mayer,A. Bellini,A. Pickard,J. Bryant,N. Roe,J. Sowter,K. Lang,Jenny C. Taylor,P. Barry,Maria Hobrok,H. Tench,R. Wolf-Roberts,H. McGuinness,R. Loosley,Daniel B Hawcutt,L. Rad,L. O'Malley,P. Saunderson,G. Seddon,Tim J. Anderson,N. Rogers,J. Ruddy,M. Harkins,C. Beith,A. McAlpine,L. Ferguson,Paul Grant,S. MacFadyen,M. McLaughlin,T. Baird,S. Rundell,B. Welsh,R. Hamill,F. Fisher,J. Gregory,Campbell A,S. Smuts,J Kenneth Baillie,J Kenneth Baillie,Gail Carson,Beatrice Alex,B. Bach,Wendy S. Barclay,Debby Bogaert,Meera Chand,Graham S Cooke,Annemarie B Docherty,Jake Dunning,A. da Silva Filipe,Tom Fletcher,Christopher A Green,Ewen M Harrison,Julian A. Hiscox,Ho A. Y. W.,Peter Horby,Samreen Ijaz,S. Khoo,W. S. Lim,Alexander J. Mentzer,Laura Merson,Alison M. Meynert,Mahdad Noursadeghi,Massimo Palmarini,William A. Paxton,Georgios Pollakis,Nicholas Price,Andrew Rambaut,David Robertson,Vanessa Sancho-Shimizu,Janet T Scott,T I de Silva,Louise Sigfrid,Tom Solomon,Shiranee Sriskandan,David I. Stuart,R.S. Tedder,E. Thomson,Alfred A.R. Thompson,Ryan S Thwaites,L Turtle,Maria Zambon,Hayley Hardwick,Chloe Donohue,Ronan A Lyons,Lisa Norman,Riinu Pius,Thomas M Drake,Cameron J Fairfield,Stephen R Knight,Kenneth A. McLean,Derek Murphy,C. A. Shaw,Jo Dalton,Michelle Girvan,Egle Saviciute,Stuart K. Roberts,Janet Harrison,Laura Marsh,Marie Connor,Sophie Halpin,Carrol Gamble,Gary Leeming,Murray Wham,William Greenhalf,V. Shaw,Sarah D. McDonald,Andrea Ganna,Patrick Sulem,D A van Heel,M. Cordioli,Gardar Sveinbjornsson,M. E. K. Niemi,Janie F. Shelton,A. J. Shastri,C. Ye,C. H. Weldon,T. Filshtein-Sonmez,D. Coker,A. Symons,J. Esparza-Gordillo,Stella Aslibekyan,Adam Auton,J. E. Krieger,E. Marques,C. E. Jannes,Francesca Mari,S. Daga,Margherita Baldassarri,Elisa Benetti,Simone Furini,Chiara Fallerini,Francesca Fava,Floriana Valentino,G. Doddato,Annarita Giliberti,Rossella Tita,Sara Amitrano,Mirella Bruttini,S. Croci,I. Meloni,A. M. Pinto,E. Frullanti,Maria Antonietta Mencarelli,C. L. Rizzo,Francesca Montagnani,L. Di Sarno,A. Tommasi,Marta Palmieri,Arianna Emiliozzi,M. Fabbiani,Barbara Rossetti,Giacomo Zanelli,Elena Bargagli,Laura Bergantini,Miriana d'Alessandro,Paolo Cameli,D. Bennet,Federico Anedda,Simona Marcantonio,Sabino Scolletta,Federico Franchi,Maria Antonietta Mazzei,S. Guerrini,Edoardo Conticini,Luca Cantarini,Bruno Frediani,D. Tacconi,C. Spertilli,M. Feri,Abele Donati,R. Scala,L. Guidelli,G. Spargi,M. Corridi,C. Nencioni,L. Croci,G. P. Caldarelli,M. Spagnesi,P. Piacentini,M. Bandini,E. Desanctis,S. Cappelli,A. Canaccini,A. Verzuri,V. Anemoli,A. Ognibene,M. Vaghi,A d'Arminio Monforte,Esther Merlini,M. U. Mondelli,S. Mantovani,S. Ludovisi,Massimo Girardis,S. Venturelli,M. Sita,Andrea Cossarizza,A. Antinori,Alessandra Vergori,Stefano Rusconi,M. Siano,A. Gabrieli,Agostino Riva,Daniela Francisci,Elisabetta Schiaroli,P. G. Scotton,F. Andretta,S. Panese,R. Scaggiante,F. Gatti,S. G. Parisi,Francesco Castelli,M. E. Quiros-Roldan,P. Magro,Isabella Zanella,M. Della Monica,Carmelo Piscopo,Mario Capasso,Roberta Russo,Immacolata Andolfo,Achille Iolascon,G. Fiorentino,M. Carella,Marco Castori,Giuseppe Merla,Filippo Aucella,P. Raggi,C. Marciano,R. Perna,Matteo Bassetti,A. Di Biagio,M. Sanguinetti,L. Masucci,Serafina Valente,Marco Mandalà,A. Giorli,L. Salerni,P. Zucchi,P. Parravicini,E. Menatti,S. Baratti,T. Trotta,F. Giannattasio,G. Coiro,F. Lena,D. A. Coviello,Cristina Mussini,G. Bosio,E. Martinelli,Sandro Mancarella,L. Tavecchia,L. Crotti,N. Picchiotti,M. Gori,C. Gabbi,M. Sanarico,S. Ceri,P. Pinoli,F. Raimondi,F. Biscarini,A. Stella,Xia Shen,Xia Shen,Chris P. Ponting,Angie Fawkes,Albert Tenesa,Albert Tenesa,Mark J. Caulfield,Richard H Scott,K Rowan,Lee Murphy,Peter J. M. Openshaw,Peter J. M. Openshaw,Malcolm G Semple,Veronique Vitart,James F. Wilson +1449 more
TL;DR: The GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units is reported, finding evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease.
Journal ArticleDOI
A minimal common outcome measure set for COVID-19 clinical research
John Marshall,Srinivas Murthy,Janet V. Diaz,Neil Adhikari,Derek C. Angus,Yaseen M. Arabi,Kenneth Baillie,Michael Bauer,Scott M. Berry,Bronagh Blackwood,Marc J. M. Bonten,Fernando A. Bozza,Frank M. Brunkhorst,Allen C. Cheng,Mike Clarke,Vu Quoc Dat,Menno de Jong,Justin T Denholm,Lennie P. G. Derde,Jake Dunning,Xiaobin Feng,Tom Fletcher,Tom Fletcher,Nadine E. Foster,Rob Fowler,Nina Gobat,Charles D. Gomersall,Anthony C. Gordon,Thomas Glueck,Michael O. Harhay,Carol L. Hodgson,Peter Horby,Yae Jean Kim,Richard Kojan,Bharath Kumar,John G. Laffey,Denis Malvey,Ignacio Martin-Loeches,Colin McArthur,Daniel F. McAuley,Stephen McBride,Shay McGuinness,Laura Merson,Susan C. Morpeth,Dale M. Needham,Mihai G. Netea,Mihai G. Netea,Myoung Don Oh,Sabai Phyu,Simone Piva,Ruijin Qiu,Halima Salisu-Kabara,Lei Shi,Naoki Shimizu,Jorge Sinclair,Steven Y. C. Tong,Alexis F. Turgeon,Timothy M. Uyeki,Frank L. van de Veerdonk,Steve Webb,Paula R Williamson,Timo Wolf,Junhua Zhang +62 more
TL;DR: A minimum set of common outcome measures for studies of COVID-19, which includes a measure of viral burden, patient survival, and patient progression through the health-care system by use of the WHO Clinical Progression Scale are urged.
Journal ArticleDOI
The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care
Matthieu Komorowski,Matthieu Komorowski,Leo Anthony Celi,Leo Anthony Celi,Omar Badawi,Omar Badawi,Omar Badawi,Anthony C. Gordon,A. Aldo Faisal +8 more
TL;DR: A reinforcement learning agent, the AI Clinician, can assist physicians by providing individualized and clinically interpretable treatment decisions to improve patient outcomes by extracting implicit knowledge from an amount of patient data that exceeds by many-fold the life-time experience of human clinicians.