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Anthony Crawley
Researcher at National Institutes of Health
Publications - 12
Citations - 5060
Anthony Crawley is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Parkinsonism & Dementia. The author has an hindex of 11, co-authored 12 publications receiving 4739 citations.
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Journal ArticleDOI
α-Synuclein Locus Triplication Causes Parkinson's Disease
Andrew B. Singleton,Matthew J. Farrer,Joshua C. Johnson,Amanda Singleton,Stephen Hague,Jennifer M. Kachergus,Mary M. Hulihan,Terhi Peuralinna,Amalia Dutra,Robert L. Nussbaum,Sarah Lincoln,Anthony Crawley,Melissa Hanson,Demetrius M. Maraganore,Charles H. Adler,Mark R. Cookson,Manfred D. Muenter,Melisa J. Baptista,David Miller,J. Blancato,John Hardy,Katrina Gwinn-Hardy +21 more
TL;DR: In this article, the α-synuclein was identified as the major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and of glial cell cytoplasmic inclusions.
Journal ArticleDOI
Donepezil for dementia in Parkinson’s disease: a randomised, double blind, placebo controlled, crossover study
Bernard Ravina,Mary E. Putt,Andrew Siderowf,John T. Farrar,M Gillespie,Anthony Crawley,Hubert H. Fernandez,M M Trieschmann,Sue Reichwein,Tanya Simuni +9 more
TL;DR: There may be a modest benefit on aspects of cognitive function in Parkinson’s disease and dementia as reflected in only one of the cognitive scales used in this study.
Journal ArticleDOI
Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals
Javier Simón-Sánchez,Sonja W. Scholz,H.C. Fung,H.C. Fung,Mar Matarin,Dena G. Hernandez,J. Raphael Gibbs,Angela Britton,Fabienne Wavrant-De Vrièze,Elizabeth Peckham,Katrina Gwinn-Hardy,Anthony Crawley,Judith C. Keen,Josefina Nash,Digamber Borgaonkar,John Hardy,Andrew B. Singleton +16 more
TL;DR: The utility of genome-wide SNP analysis in the direct detection of extended homozygosity and structural genomic variation is described and it is likely that this powerful methodology will augment existing techniques in the identification of chromosomal abnormalities.
Journal ArticleDOI
Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation
Stephen Hague,Ekaterina Rogaeva,Dena G. Hernandez,Cindy Gulick,Amanda Singleton,Melissa Hanson,Janel O. Johnson,Roberto Weiser,Marisol Gallardo,Bernard Ravina,Katrina Gwinn-Hardy,Anthony Crawley,Peter St George-Hyslop,Anthony E. Lang,Peter Heutink,Vincenzo Bonifati,Vincenzo Bonifati,John Hardy,Andrew B. Singleton +18 more
TL;DR: Observed sequence alterations in DJ‐1 are a rare cause of early‐onset PD, and one subject was diagnosed with probable PD at age 24 years with asymmetric onset and an excellent response to levodopa therapy.
Journal ArticleDOI
Association between cardiac denervation and parkinsonism caused by α‐synuclein gene triplication
Amanda Singleton,Katrina Gwinn-Hardy,Yehonotan Sharabi,Sheng-Ting Li,Courtney Holmes,Raghuveer Dendi,John Hardy,Andrew B. Singleton,Anthony Crawley,David S. Goldstein +9 more
TL;DR: Cardiac PET scanning in a large, well characterized family of Parkinson’s disease patients indicates that both parkinsonism and cardiac sympathetic denervation can result from an excess of normal synuclein.