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Anthony G. Uren
Researcher at Imperial College London
Publications - 35
Citations - 3736
Anthony G. Uren is an academic researcher from Imperial College London. The author has contributed to research in topics: Gene & Insertional mutagenesis. The author has an hindex of 22, co-authored 34 publications receiving 3443 citations. Previous affiliations of Anthony G. Uren include Royal Melbourne Hospital & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
Anthony G. Uren,Lee Lee Wong,Miha Pakusch,Kerry J. Fowler,Francis J. Burrows,David L. Vaux,K. H. Andy Choo +6 more
TL;DR: In vertebrates, Survivin and INCENP have related roles in mitosis, coordinating events such as microtubule organization, cleavage-furrow formation and cytokinesis, and like their yeast homologs Bir1 and Sli15, they may also act together with the Aurora kinase.
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Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.
TL;DR: Results suggest that IAP proteins that inhibit apoptosis may do so by regulating signals required for activation of ICE-like proteases, as MIHB and MIHC were able to bind to the tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 in yeast two-hybrid assays.
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Retroviral insertional mutagenesis: past, present and future
TL;DR: The mechanisms by which retroviral insertions mutate cellular genes, the practical aspects of insertion site cloning, the identification and analysis of common insertion sites, and the potential for use of somatic insertional mutagens in the study of nonhaematopoietic and nonmammary tumour types are discussed.
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The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone.
TL;DR: Deregulation of bir-1 promotes changes in ploidy, suggesting that similar deregulation of mammalian BIRPs may contribute to tumorigenesis, and it is proposed that BIR-1 localizes AIR-1 to chromosomes and perhaps to the spindle midzone, where AIR-2 phosphorylates proteins that affect chromosome behavior and spindleMidzone organization.
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Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts
TL;DR: Amino acid display was performed using the program ASAD developed by Keith Satterly, WEHI, and is available by anonymous ftp from: ftp.wehi.edu.au/pub/biology/ASAD.